Production and reversal of sensitivity to sound-induced convulsions associated with a pyridoxin deficiency.

Abstract

Several etiological factors seem to predispose various species of animals to convulsions characterized by running, clonic movements, and occasionally tonicity, with a comatose recovery period. Sensory stimulation, particularly sound, often precipitates the seizures. The various aspects of the subject, with emphasis on convulsions in rats, have been reviewed recently (1).

Sound-precipitated convulsions: 1947-1954.

“…The animals on the basal diet were otherwise apparently healthy. Sensitivity can also be reduced by supplements of pyridoxin, if a deficiency of pyridoxin has been induced, this latter requiring feeding of the deficient diet from birth (120). In a cleverly conceived experiment, Griffiths (60) tested for susceptibility during twoweek periods when his .Ss were maintained on a stock diet and a selfselection diet.…”