Activation cross sections for proton induced reactions on Sm are presented for the first time for nat Sm(p,xn) 154,152m2,152m1,152g,150m,150g,149,148,147,146,145 Eu, nat Sm(p,x) 153,145 Sm, nat Sm(p,x) 151,150,149,148g,148m,146,144,143 Pm and nat Sm(p,x) 141 Nd up to 65 MeV. The cross sections were measured via activation method by using a stacked-foil irradiation technique and high resolution gamma ray spectroscopy. The results were compared with results of the nuclear reaction codes ALICE, EMPIRE and TALYS (results taken from TENDL libraries). Integral yields of the activation products were calculated from the excitation functions.