Production of a Broad Spectrum Antimicrobial Substance by<i>Lactobacillus reuteri</i>

Axelsson, Lars; Chung, Tung-Ching; Dobrogosz, Walter J.; Lindgren, Sven

doi:10.3109/08910608909140210

Cited by 262 publications

(164 citation statements)

References 8 publications

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“…We chose L reuteri because it is found naturally in humans and has been studied well with evidence to support its role as a protective organism with immunomodulation and bactericidal properties. [22][23][24][25][26] …”

Section: Resultsmentioning

confidence: 99%

Prophylactic Probiotics to Prevent Death and Nosocomial Infection in Preterm Infants

et al. 2012

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Section: Resultsmentioning

confidence: 99%

Prophylactic Probiotics to Prevent Death and Nosocomial Infection in Preterm Infants

et al. 2012

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“…This is quite different from the situation in Salmonella, where glucose and other carbohydrates strongly repress the expression of the pdu genes, preventing cofermentation of 1,2-PD (or glycerol) with simple carbohydrates (95,100). Another interesting aspect of glycerol degradation by L. reuteri is that it leads to the production of HPA (also known as reuterin), a broad-spectrum antibiotic associated with the probiotic effects of L. reuteri (152,153). Whole-genome sequence analysis revealed that genes responsible for glycerol degradation are part of the L. reuteri pdu operon (154).…”

Section: In Lactobacillus the Pdu Mcp Is Likely Used For 12-pd Andmentioning

confidence: 92%

Diverse Bacterial Microcompartment Organelles

Chowdhury

Sinha

Chun

et al. 2014

Microbiol Mol Biol Rev

214

278

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SUMMARY Bacterial microcompartments (MCPs) are sophisticated protein-based organelles used to optimize metabolic pathways. They consist of metabolic enzymes encapsulated within a protein shell, which creates an ideal environment for catalysis and facilitates the channeling of toxic/volatile intermediates to downstream enzymes. The metabolic processes that require MCPs are diverse and widely distributed and play important roles in global carbon fixation and bacterial pathogenesis. The protein shells of MCPs are thought to selectively control the movement of enzyme cofactors, substrates, and products (including toxic or volatile intermediates) between the MCP interior and the cytoplasm of the cell using both passive electrostatic/steric and dynamic gated mechanisms. Evidence suggests that specialized shell proteins conduct electrons between the cytoplasm and the lumen of the MCP and/or help rebuild damaged iron-sulfur centers in the encapsulated enzymes. The MCP shell is elaborated through a family of small proteins whose structural core is known as a bacterial microcompartment (BMC) domain. BMC domain proteins oligomerize into flat, hexagonally shaped tiles, which assemble into extended protein sheets that form the facets of the shell. Shape complementarity along the edges allows different types of BMC domain proteins to form mixed sheets, while sequence variation provides functional diversification. Recent studies have also revealed targeting sequences that mediate protein encapsulation within MCPs, scaffolding proteins that organize lumen enzymes and the use of private cofactor pools (NAD/H and coenzyme A [HS-CoA]) to facilitate cofactor homeostasis. Although much remains to be learned, our growing understanding of MCPs is providing a basis for bioengineering of protein-based containers for the production of chemicals/pharmaceuticals and for use as molecular delivery vehicles.

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“…A more recent one from FAO/WHO is the following: "live microorganisms that when being administered in appropriate dose, they confer a benefit of health to the receiver." Some of the health benefits which have been claimed for probiotics include the following: improvement of the normal microflora (2), prevention of infectious diseases (3,6,9,11,13,65,83) and food allergies (51,61), reduction of serum cholesterol (23,77), anticarcinogenic activity (14,18,33,35,73), stabilization of the gut mucosal barrier (79), immune adjuvant properties (15,20,24,28,36,40,77,80,92), alleviation of intestinal bowel disease symptoms (31,82), and improvement in the digestion of lactose in intolerant hosts (19,42).…”

Section: Nonpathogenic Probiotic Bacteriamentioning

confidence: 99%