Proposed Model: Mechanisms of Immunomodulation Induced by Probiotic Bacteria

Galdeano, Carolina Maldonado; LeBlanc, Alejandra de Moreno de; Vinderola, Gabriel; Bonet, María Eugenia Bibas; Perdigón, Gabriela

doi:10.1128/cvi.00406-06

Cited by 291 publications

(228 citation statements)

References 90 publications

(74 reference statements)

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“…This procedure avoids the possibility that any obtained effects caused by the probiotic are due to the stimulation of the gastrointestinal tract as a consequence of swallowed inoculum. Also, if anaesthetized mice swallowed a small part of the inoculum, the amount of swallowed bacteria would be insufficient to affect the mucosal or systemic immune response, according to Galdeano et al (2007).…”

Section: Discussionmentioning

confidence: 99%

Modulation of the immuno-coagulative response in a pneumococcal infection in malnourished mice nasally treated with Lactobacillus casei

Zelaya

Laiño

Haro

et al. 2013

Journal of Medical Microbiology

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We studied the systemic effects of the intranasal administration of Lactobacillus casei on the immuno-coagulative response in pneumoccocal infection in immunocompromised mice. Weaned mice consumed a protein-free diet (PFD) for 21 days and were therefore malnourished. Malnourished mice were fed a balanced conventional diet (BCD) for 7 days (BCD group) or a BCD for 7 days with nasal administration of viable L. casei on days 6 and 7 (BCD+LcN group). The malnourished control mice (MNC) received a PFD, whereas the well-nourished control mice (WNC) continually consumed a BCD. At the end of the treatment period, the mice were infected with Streptococcus pneumoniae. At different times after infection, we analysed the following parameters: global coagulation system, activation of coagulation, coagulation inhibitors, platelet count, leukocyte count and myeloperoxidase (MPO) activity, total proteins, albumin and acute phase proteins (APPs). The MNC group showed greater impairment in the coagulation tests and an increase in the positive APPs. These parameters were normalized by the L. casei treatment. However, the number of leukocytes, decreased by malnutrition, was improved only by the administration of L. casei. After infection, the BCD+LcN group showed similar results to those of the WNC group for most of the haemostatic parameters. The BCD+LcN group did not show significant variations in the prothrombin time or in the level of anticoagulant protein C, but showed higher levels of fibrinogen, platelets, albumin, leukocytes and MPO activity compared with the different experimental groups. The intranasal administration of L. casei was effective in modulating the pro-inflammatory aspects of coagulation without affecting coagulation itself.

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Section: Discussionmentioning

confidence: 99%

Modulation of the immuno-coagulative response in a pneumococcal infection in malnourished mice nasally treated with Lactobacillus casei

Zelaya

Laiño

Haro

et al. 2013

Journal of Medical Microbiology

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“…IFN-is involved in the maturation of immune cells (dendritic cells), controls their cellular proliferation at the intestinal level and induce other cytokines, especially IL-4, IL-5 and IL-10. Because of its role in mediating macrophage and NK cell activation, IFN-is important in the host defense against intracellular pathogens, viruses and tumors [133]. According to Perdigón et al [134] IL-4 exerts control over the inflammatory response induced by the carcinogen.…”

Section: Effects Of Enterococcus Faecium Crl 183 On Intestinal Microbmentioning

confidence: 99%

Probiotics and Intestinal Microbiota: Implications in Colon Cancer Prevention

Sivieri¹,

Bedani²,

Cavallini³

et al. 2013

Lactic Acid Bacteria - R &Amp; D for Food, Health and Livestock Purposes

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“…Not only can this but also, hey prevent tumor cell via the activation of immunity by immune cells to fight with the tumor cells, delay the onset of tumor or increase the survival rate. Galdeano et al (2007),analyzed the profile of cytokines induced by some LAB strains and observed that the most remarkable effect for all the LAB strains tested is the increase in TNF-α, interferon-γ (IFN-γ) and the regulatory cytokineIL-10. As Lee et al 2004, LAB such as L. acidophilus, Lactobacillus casei (L.casei) and B. longum have been shown to possess immunomodulatory and antitumor effects by suppressing the proliferation of tumor cells and prolonging survival.…”

Section: Lab In Inhibition Of Tumor Cell Proliferationmentioning

confidence: 99%

Overview of Anticancer activity of Lactic Acid bacteria

Delesa¹

2017

Int. J. Adv. Res. Biol. Sci.

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Cancer vestiges one of the leading causes of deaths worldwide despite its advances treatment and detection and the conventional chemotherapeutic agents used for the treatment of cancer have non-specific toxicity toward normal body cells that cause various side effects. In addition, cancer cells are known to develop chemotherapy resistance in due course of treatment, so, it's difficult and not easy to treat cancer using normal antiviral drugs. Thus, the demand for novel anti-cancer agents is increasing important to develop novel biological control approach. Some research reports have shown the therapeutic potential of LAB against various types of cancer cell lines. This makes them promising candidates for further investigation and clinical treatments. While a myriad of healthful effects have been attributed to lactic acid bacteria (LAB), perhaps the most controversial remains that of anticancer activity. The precise mechanisms by which LAB may inhibit any cancer are currently unknown. However, such mechanisms might include: alteration of the metabolic activities of intestinal microflora; alteration of physico-chemical conditions in the colon and gut; binding and degrading potential carcinogens; quantitative and/or qualitative alterations in the intestinal microflora incriminated in producing putative carcinogen(s) and promoters; production of antitumourigenic or antimutagenic compounds; enhancing the host's immune response; and effects on physiology of the host. In this review article, we present the overview of anticancer activity of the lactic acid bacteria.

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Proposed Model: Mechanisms of Immunomodulation Induced by Probiotic Bacteria

Cited by 291 publications

References 90 publications

Modulation of the immuno-coagulative response in a pneumococcal infection in malnourished mice nasally treated with Lactobacillus casei

Modulation of the immuno-coagulative response in a pneumococcal infection in malnourished mice nasally treated with Lactobacillus casei

Probiotics and Intestinal Microbiota: Implications in Colon Cancer Prevention

Overview of Anticancer activity of Lactic Acid bacteria

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