Production of bacterial cellulose tubes for biomedical applications: Analysis of the effect of fermentation time on selected properties

Salinas, D R Corzo; Sordelli, A; Martínez, Luis Alfredo; Villoldo, Gustavo; Bernal, Celina Raquel; Pérez, Maximiliano; Cerrutti, Patricia; Foresti, María Laura

doi:10.1016/j.ijbiomac.2021.08.011

Cited by 14 publications

(11 citation statements)

References 52 publications

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“…The WHC kept on reducing with every drying and re-swelling cycle, however, it was important to observe that even after the fifth re-swelling cycle process, BC and BCC were able to hold more than 20% water of their dry weight. High WHC and slow WRR from BCC hydrogels are significant features for their applicability in medical and environmental fields [ 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Biological Features of Cactus Coated Bacterial Cellulose Hydrogels

Kamal

Ul-Islam

Khan

et al. 2022

Gels

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The current study was aimed at developing BC-Cactus (BCC) composite hydrogels with impressive mechanical features for their potential applications in medical and environmental sectors. BCC composites hydrogels were developed through cactus gel coating on a never dried BC matrix. The FE-SEM micrographs confirmed the saturation of BC fibrils with cactus gel. Additionally, the presence of various functional groups and alteration in crystalline behavior was confirmed through FTIR and XRD analysis. Mechanical testing illustrated a three-times increase in the strain failure and an increase of 1.6 times in the tensile strength of BCC composite. Absorption capabilities of BCC were much higher than pure BC and it retained water for a longer period of time. Additionally, the rewetting and absorption potentials of composites were also higher than pure BC. The composite efficiently adsorbed Pb, Zn, Cu, and Co metals. Biocompatibility studies against human HaCat cell line indicated much better cell adhesion and proliferation of BCC compared to BC. These findings advocate that the BCC composite could find applications in medical, pharmaceutical and environmental fields.

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Section: Resultsmentioning

confidence: 99%

Preparation, Characterization, and Biological Features of Cactus Coated Bacterial Cellulose Hydrogels

Kamal

Ul-Islam

Khan

et al. 2022

Gels

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“…A common static fermentation method for producing tubular BNC involves the use of plugged silicone molds with culture media inside, orientated either vertically or horizontally. The use of a silicone mold rather than glass allows for oxygen to permeate through. , The inner diameter of the molds determines the outer diameter of the BNC tubes. A study by Putra et al compared different diameters of silicone tubes using this setup as well as the use of a rectangular silicone mold instead of a tube.…”

Section: Bacterial Nanocellulose As Artificial Vascular Graftsmentioning

confidence: 99%

“…Static fermentation methods for fabricating tubular BNC involve the use of tube-shaped oxygen permeable fermenters, typically consisting of one or two concentric tubes of glass or oxygen permeable materials such as polydimethylsiloxane (PDMS) (Figure C) . The first known static fermentation method developed for BNC tubes used a glass tube surrounded with culture media within a glass chamber to produce tubular BNC, with several variations of this setup having been patented. − ,,,− The resulting BNC tubes were termed BActerial SYnthesized Cellulose (BASYC).…”

Section: Bacterial Nanocellulose As Artificial Vascular Graftsmentioning

confidence: 99%

Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications

et al. 2023

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Understanding the interaction between biomaterials and blood is critical in the design of novel biomaterials for use in biomedical applications. Depending on the application, biomaterials can be designed to promote hemostasis, slow or stop bleeding in an internal or external wound, or prevent thrombosis for use in permanent or temporary medical implants. Bacterial nanocellulose (BNC) is a natural, biocompatible biopolymer that has recently gained interest for its potential use in blood-contacting biomedical applications (e.g., artificial vascular grafts), due to its high porosity, shapeability, and tissue-like properties. To promote hemostasis, BNC has been modified through oxidation or functionalization with various peptides, proteins, polysaccharides, and minerals that interact with the coagulation cascade. For use as an artificial vascular graft or to promote vascularization, BNC has been extensively researched, with studies investigating different modification techniques to enhance endothelialization such as functionalizing with adhesion peptides or extracellular matrix (ECM) proteins as well as tuning the structural properties of BNC such as surface roughness, pore size, and fiber size. While BNC inherently exhibits comparable mechanical characteristics to endogenous blood vessels, these mechanical properties can be enhanced through chemical functionalization or through altering the fabrication method. In this review, we provide a comprehensive overview of the various modification techniques that have been implemented to enhance the suitability of BNC for blood-contacting biomedical applications and different testing techniques that can be applied to evaluate their performance. Initially, we focused on the modification techniques that have been applied to BNC for hemostatic applications. Subsequently, we outline the different methods used for the production of BNC-based artificial vascular grafts and to generate vasculature in tissue engineered constructs. This sequential organization enables a clear and concise discussion of the various modifications of BNC for different blood-contacting biomedical applications and highlights the diverse and versatile nature of BNC as a natural biomaterial.

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“…[ 141 ] Complete cell proliferation requires a permeable structural matrix. [ 142 ] Various cell lines, such as human smooth muscle cells and human chondrocytes, exhibit better proliferation behavior on microporous BC surfaces. Therefore, larger pores are crucial for promoting wound healing.…”

Section: Improvement Of the Biocompatibility Of Bc‐based Wound Dressingsmentioning

confidence: 99%

Bacterial Cellulose Applied in Wound Dressing Materials: Production and Functional Modification – A Review

Hou,

Xia,

Pan

et al. 2023

Macromolecular Bioscience

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In recent years, the development of new type wound dressings has gradually attracted more attention. Bacterial cellulose (BC) is a natural polymer material with various unique properties, such as ultrafine three‐dimensional nano‐network structure, high water retention capacity and biocompatibility. These properties allow BC to be used independently or in combination with different components (such as biopolymers and nanoparticles) to achieve diverse effects. This means that BC has great potential as a wound dressing. However, systematic summaries for the production and commercial application of BC‐based wound dressings are still lacked. Therefore, this review provides a detailed introduction to the production fermentation process of BC, including various production strains and their biosynthetic mechanisms. Subsequently, with regard to the functional deficiencies of bacterial cellulose as a wound dressing, recent research progress in this area are enumerated. Finally, prospects are discussed for the low‐cost production and high‐value‐added product development of BC‐based wound dressings.This article is protected by copyright. All rights reserved

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Production of bacterial cellulose tubes for biomedical applications: Analysis of the effect of fermentation time on selected properties

Cited by 14 publications

References 52 publications

Preparation, Characterization, and Biological Features of Cactus Coated Bacterial Cellulose Hydrogels

Preparation, Characterization, and Biological Features of Cactus Coated Bacterial Cellulose Hydrogels

Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications

Bacterial Cellulose Applied in Wound Dressing Materials: Production and Functional Modification – A Review

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