2018
DOI: 10.3389/fmicb.2018.02046
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Production of Food and Feed Additives From Non-food-competing Feedstocks: Valorizing N-acetylmuramic Acid for Amino Acid and Carotenoid Fermentation With Corynebacterium glutamicum

Abstract: Corynebacterium glutamicum is used for the million-ton-scale production of food and feed amino acids such as L-glutamate and L-lysine and has been engineered for production of carotenoids such as lycopene. These fermentation processes are based on sugars present in molasses and starch hydrolysates. Due to competing uses of starch and sugars in human nutrition, this bacterium has been engineered for utilization of alternative feedstocks, for example, pentose sugars present in lignocellulosic and hexosamines suc… Show more

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Cited by 25 publications
(21 citation statements)
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“…In C. glutamicum, the absence of a specific uptake system prevents the utilization of extracellular N-acetylglucosamine, requiring heterogeneous expression of nagE from Corynebacterium glycinophilum; this expression enables prompt transportation and feasible assimilation of N-acetylglucosamine. Co-expression of exogenous nagA, nagB, and nagE generated C. glutamicum capable of producing various chemicals, including L-lysine (Sgobba et al, 2018), L-citrulline (Eberhardt et al, 2014), lycopene (Matano et al, 2014), putrescine (Uhde et al, 2013), 7-chloro-L-tryptophan (Veldmann et al, 2019), 5aminovalerate (Jorge et al, 2017b), gamma-aminobutyric acid (Jorge et al, 2017a), ectoine (Perez-Garcia et al, 2017), and L-pipecolic acid (Pérez-García et al, 2017) from N-acetylglucosamine. Consequently, N-acetylglucosamine is a promising alternative carbon source for C. glutamicum, although further investigation is required to accelerate the conversion from N-acetylglucosamine to bulk chemicals at the industrial scale.…”
Section: N-acetylglucosaminementioning
confidence: 99%
“…In C. glutamicum, the absence of a specific uptake system prevents the utilization of extracellular N-acetylglucosamine, requiring heterogeneous expression of nagE from Corynebacterium glycinophilum; this expression enables prompt transportation and feasible assimilation of N-acetylglucosamine. Co-expression of exogenous nagA, nagB, and nagE generated C. glutamicum capable of producing various chemicals, including L-lysine (Sgobba et al, 2018), L-citrulline (Eberhardt et al, 2014), lycopene (Matano et al, 2014), putrescine (Uhde et al, 2013), 7-chloro-L-tryptophan (Veldmann et al, 2019), 5aminovalerate (Jorge et al, 2017b), gamma-aminobutyric acid (Jorge et al, 2017a), ectoine (Perez-Garcia et al, 2017), and L-pipecolic acid (Pérez-García et al, 2017) from N-acetylglucosamine. Consequently, N-acetylglucosamine is a promising alternative carbon source for C. glutamicum, although further investigation is required to accelerate the conversion from N-acetylglucosamine to bulk chemicals at the industrial scale.…”
Section: N-acetylglucosaminementioning
confidence: 99%
“…In addition to glucose, C. glutamicum uses several substrates such as sugars present in molasses (sucrose and fructose), pentose sugars present in lignocellulosic (Zahoor et al, 2012), n-acetyl-D-glucosamine and n -acetyl-D-muramic acid (Sgobba et al, 2018) for manufacturing of various amino acids (Bommareddy et al, 2014). Production of other compounds such as isobutanol, cadaverine, and succinate are possible with C. glutamicum (Blombach et al, 2011; Buschke et al, 2011; Litsanov et al, 2012).…”
Section: Production Of Important Compoundsmentioning
confidence: 99%
“…Similarly, Escherichia coli has become one of the best cell reactors to produce alcohols, organic acids, biodiesel, even hydrogen by utilizing renewable resources (13). Other bacteria such as Bacillus subtilis (14), Caldicellulosiruptor bescii (15), Corynebacterium glutamicum (16), and Ruminococcaceae bacterium (17) were identified and evaluated with the capacity to generate different products by converting renewable carbon sources. Notably, some microorganisms were reported to degrade keratinous waste effectively (18).…”
Section: Introductionmentioning
confidence: 99%