“…In C. glutamicum, the absence of a specific uptake system prevents the utilization of extracellular N-acetylglucosamine, requiring heterogeneous expression of nagE from Corynebacterium glycinophilum; this expression enables prompt transportation and feasible assimilation of N-acetylglucosamine. Co-expression of exogenous nagA, nagB, and nagE generated C. glutamicum capable of producing various chemicals, including L-lysine (Sgobba et al, 2018), L-citrulline (Eberhardt et al, 2014), lycopene (Matano et al, 2014), putrescine (Uhde et al, 2013), 7-chloro-L-tryptophan (Veldmann et al, 2019), 5aminovalerate (Jorge et al, 2017b), gamma-aminobutyric acid (Jorge et al, 2017a), ectoine (Perez-Garcia et al, 2017), and L-pipecolic acid (Pérez-García et al, 2017) from N-acetylglucosamine. Consequently, N-acetylglucosamine is a promising alternative carbon source for C. glutamicum, although further investigation is required to accelerate the conversion from N-acetylglucosamine to bulk chemicals at the industrial scale.…”