Production of functional spherical particles with porous hollow structures in water via oiling-out directional agglomeration

Abstract

Porous hollow spherical particles benefit from special structural features and fascinating physicochemical properties resulting in widespread application. Particularly in pharmaceutical engineering, they have significant advantages for direct compression and drug...

Oiling‐Out in Industrial Crystallization of Organic Small Molecules: Mechanisms, Characterization, Regulation, and Applications

“…developed a functional spherical particle with porous hollow structures in water via oiling‐out. [ 96 ] As shown in Figure 9b, the temperature increase triggers the oiling‐out of the system, where indomethacin is dissolved in oil droplets of L‐menthol. After the system has equilibrated, rapid cooling prompts the nucleation of indomethacin, leading to the formation of a compact spherical co‐agglomerate.…”

Novel Spherical Trimethoprim–Niflumic Acid Drug–Drug Salt Demonstrates Simultaneous Enhancement of Powder Property and Antibacterial Activity

“…Spherical crystallization is a simple and reliable technology for engineering particles of active pharmaceutical ingredients (APIs). It transforms microcrystalline particles into spherical agglomerates during crystallization, eliminates the granulation process between the crystallization and tableting in the pharmaceutical industry, facilitates direct compression, and simplifies the formulation preparation process. , This approach allows improvements in particle attributes such as flowability, tabletability, , compressibility, , and chemical stability across numerous studies. Two APIs can form a cocrystal or salt within the same crystal lattice to achieve a drug–drug combination based on noncovalent bonds.…”

Preparation and Formation Mechanism of Spherical Particles with High Quality: A Case Study of l-Isoleucine

“…Liu et al used agglomeration technology to successfully design indomethacin hollow spherical particles with controllable thickness and particle size and piggybacked nifedipine to realize the core−shell structure of indomethacin wrapped around nifedipine to realize the coupling of analgesic and therapeutic drugs. 29 All of these methods reflect the maturity and practicability of spherical aggregation technology.…”