Production of highly crosslinked microspheres by the precipitation polymerization of 2‐(diethylamino)ethyl methacrylate with two or three functional crosslinkers

Abstract

Precipitation polymerizations of 2-(diethylamino)ethyl methacrylate were carried out with ethylene glycol dimethacrylate and then trimethylolpropane trimethacrylate in acetonitrile to produce monodisperse, highly crosslinked microspheres. Poly(diethylaminoethyl methacrylate-co-trimethylolpropane trimethacrylate) [poly (DEAEMA-co-TRIM)] microspheres, in the range of 1.2-2.7 lm, were obtained with a total monomer concentration of 1 vol % with respect to the solvent, and they kept their identity with several polymerization parameters. When the total monomer concentration was increased further, individual particles lost their identity and aggregated. Poly (DEAEMA-co-TRIM) particles with a total monomer concentration of 1 vol % had more discrete spherical forms with smoother surfaces, whereas in the poly(diethylaminoethyl methacrylate-co-ethylene glycol dimethacrylate) system, sticky microspheres were obtained with a total monomer concentration of 2.1 vol %. Moreover, several polymerization parameters were investigated to control the physical properties of microspheres of poly(DEAEMAco-TRIM) and to understand the nature of the precipitation polymerization. Thus, the average particle size increased from 2.3 to 2.7 lm with an increased azobisisobutyronitrile concentration and then decreased to about 1.2 lm as the polymerization temperature was increased. All the microspheres produced under different polymerization conditions were found to be monodisperse (polydispersity index <0.1) with a narrow size distribution.

Microcapsules Containing pH-Responsive, Fluorescent Polymer-Integrated MoS2: An Effective Platform for in Situ pH Sensing and Photothermal Heating

“…The conjugation between the poly­(DEA- r -BMA)-RB and the MoS 2 NSs was further supported by UV–vis–NIR spectra and ATR–FTIR spectroscopies (Figure S7). The ATR–FTIR spectrum of the F-MoS 2 NSs showed the stretched C–H and CO stretching peaks at 2963 and 1727 cm –1 , respectively, from poly­(DEA- r -BMA)-RB, whereas that of the pristine MoS 2 NS showed a broad peak around 3400 cm –1 . , We also confirmed the anchoring of the polymers on the F-MoS 2 NSs by TGA, from which the areal chain density of the polymers on the surface of the MoS 2 NSs was calculated to be 0.07 chain nm –2 (Figure S8). , The anchoring of the polymers on the MoS 2 NSs significantly altered the dispersion properties (Figure S9).…”

In Situ Incorporation of Praziquantel in Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

“…The cationic monomers DEAEMA and DMAEMA are the ones used most widely for this purpose . When cationic monomers were used, the adopted experimental procedure was similar to the one described previously for preparation of PMMA microparticles also at 80 °C, although the organic phase contained the comonomer mixture and the initiator AIBN, reported frequently in the literature as an efficient initiator for these cationic monomers . The employed experimental recipes are shown in Table 2 .…”

Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold

“…Different from most aerogels reported in the literature, microsphere structured aerogel is a unique material that can be used as a template for drug delivery, superabsorbent, synthesizing porous inorganic catalysts or functional composite particle, cell culture growth template, targeted release system, etc. − Microspheres can be principally produced using various well-known techniques. However, because of aerogel’s mechanical properties, it is difficult, rather impossible, to obtain spherical microparticles by milling or crushing of the monolithic aerogels.…”