Production of Medicinal Compounds from Endangered and Commercially Important Medicinal Plants through Cell and Tissue Culture Technology for Herbal Industry

Sood, Hemant

doi:10.5772/intechopen.90742

Cited by 3 publications

(2 citation statements)

References 63 publications

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“…To ensure safety and quality of ayurvedic formulations, modern techniques which guarantee sustainable management and survival of medicinal plants is necessary (Shanmuganandhan et al 2016). Bioprospecting could be a major breakthrough in this regard, which utilizes the traditional knowledge through ethno-pharmacological investigations for sustainable use of natural resources (Rastogi and Kaphle 2011;Sharma et al 2013;Purkayastha 2016;Hemant Sood 2020). The development of modern techniques such as genetic engineering, advancements in culture techniques and fermentation has led to the large-scale biosynthesis of highly efficient bioactive natural products (Chen et al 2018).…”

Section: Bioprospecting: a Future Perspective For Natural Resourcesmentioning

confidence: 99%

Pitfalls and promises of raw drug identification techniques in the ayurvedic industry: an overview

2020

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India, with a rich heritage of floral diversity, is well-known for its medicinal plant wealth and is the largest producer of medicinal herbs in the world. Ethnobiological Survey of Ministry of Environment and Forests (MOEF) could identify 8000 plant species utilized in various systems of medicine with approximately 25,000 effective herbal formulations. The extensive consumption to meet demand-supply ratio exerts a heavy strain on the existing resources. This subsequently led to the adulteration and substitution of medicinal plants with look-alike species. The consumer's faith on herbal medicine is in the phase of decline due to the extremities in adulteration/substitution and ensuing consequences. It is imperative to bring forth universally acceptable standard tools to authenticate raw drugs before being processed further into formulations. A vast array of techniques such as physical, chemical (analytical), biochemical, anatomical, organoleptic, and recently emerged DNA based molecular methods are widely used for plant species authentication. In recent years, DNA barcoding has made remarkable progress in the field of medicinal plants research. DNA metabarcoding is the latest development for qualitative evaluation of the herbal formulations, whereas for quantitative analysis, combination of pharmacognostic, pharmacovigilance and analytical methods are inevitable for authentication. This review addresses the overall strengths and shortcomings of the existing as well as recently emerged techniques in authenticating ayurvedic raw drugs.

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Section: Bioprospecting: a Future Perspective For Natural Resourcesmentioning

confidence: 99%

Pitfalls and promises of raw drug identification techniques in the ayurvedic industry: an overview

2020

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“…Plant cell and tissue culture offer an opportunity for the propagation of plants as well as the production of phytochemicals [54]. Many plant species can be regenerated in vitro through several approaches started by explants.…”

Section: Introductionmentioning

confidence: 99%

Biotechnology and In Vitro Culture as an Alternative System for Secondary Metabolite Production

et al. 2022

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Medicinal plants are rich sources of bioactive compounds widely used as medicaments, food additives, perfumes, and agrochemicals. These secondary compounds are produced under stress conditions to carry out physiological tasks in plants. Secondary metabolites have a complex chemical structure with pharmacological properties. The widespread use of these metabolites in a lot of industrial sectors has raised the need to increase the production of secondary metabolites. Biotechnological methods of cell culture allow the conservation of plants, as well as the improvement of metabolite biosynthesis and the possibility to modify the synthesis pathways. The objective of this review is to outline the applications of different in vitro culture systems with previously reported relevant examples for the optimal production of plant-derived secondary metabolites.

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Predicting phytochemical diversity of medicinal and aromatic plants (MAPs) across eco-climatic zones and elevation in Uttarakhand using Generalized Additive Model

Tiwari

Kewlani

Gaira

et al. 2023

Sci Rep

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The present study uses a systematic approach to explore the phytochemical composition of medicinal plants from Uttarakhand, Western Himalaya. The phytochemical composition of medicinal plants was analyzed based on (i) the presence of different chemical groups and (ii) bioactive compounds. The Generalized Additive Model (GAM) analysis was used to predict the occurrence of chemical groups and active compounds across different eco-climatic zones and the elevation in Uttarakhand. A total of 789 medicinal plants represented by 144 taxonomic families were screened to explore the phytochemical diversity of the medicinal plants of Uttarakhand. These medicinal plant species are signified in different life forms such as herbs (58.86%), shrubs (18.24%), trees (17.48%), ferns (2.38%), and climbers (2.13%). The probability of occurrence of the chemical groups found in tropical, sub-tropical, and warm temperate eco-climatic zones, whereas active compounds have a high Probability towards alpine, sub-alpine, and cool temperate zones. The GAM predicted that the occurrence of species with active compounds was declining significantly (p < 0.01), while total active compounds increased across elevation (1000 m). While the occurrence of species with the chemical group increased, total chemical groups were indicated to decline with increasing elevation from 1000 m (p < 0.000). The current study is overwhelmed to predict the distribution of phytochemicals in different eco-climatic zones and elevations using secondary information, which offers to discover bioactive compounds of the species occurring in the different eco-climatic habitats of the region and setting the priority of conservation concerns. However, the study encourages the various commercial sectors, such as pharmaceutical, nutraceutical, chemical, food, and cosmetics, to utilize unexplored species. In addition, the study suggests that prioritizing eco-climatic zones and elevation based on phytochemical diversity should be a factor of concern in the Himalayan region, especially under the climate change scenario.

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Production of Medicinal Compounds from Endangered and Commercially Important Medicinal Plants through Cell and Tissue Culture Technology for Herbal Industry

Cited by 3 publications

References 63 publications

Pitfalls and promises of raw drug identification techniques in the ayurvedic industry: an overview

Pitfalls and promises of raw drug identification techniques in the ayurvedic industry: an overview

Biotechnology and In Vitro Culture as an Alternative System for Secondary Metabolite Production

Predicting phytochemical diversity of medicinal and aromatic plants (MAPs) across eco-climatic zones and elevation in Uttarakhand using Generalized Additive Model

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