Production of Microcytic Hypochromic Anemia in Puppies on Synthetic Diet Deficient in Rat Antidermatitis Factor (Vitamin B6)

Fouts, Paul J.; Helmer, O. M.; Lepkovsky, Samuel; Jukes, Thomas H.

doi:10.1093/jn/16.2.197

Cited by 53 publications

(8 citation statements)

References 9 publications

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“…They occurred when only thiamin, riboflavin and nicotinic acid represented the "B" vitamins or when "parenteral" liver extract, the Cohn fraction or the press cake fraction was furnished in addition to these vitamins. (5,6) and rats (7) and have been attributed to pyridoxine deficiency. Anemia.…”

Section: Discussionmentioning

confidence: 99%

The Prevention of Sensory Neuron Degeneration in the Pig, With Special Reference to the Rôle of Various Liver Fractions 1

Wintrobe¹,

Mushatt²,

Kolb³

et al. 1942

J. Clin. Invest.

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In previous reports (1, 2) a description was given of abnormal gait and degeneration in the nervous system which developed in pigs under certain experimental conditions. It was suggested that these effects were the result of a dietary deficiency and evidence was presented which indicated that the changes took place in spite of adequate amounts of vitamin A, thiamin, riboflavin, nicotinic acid or vitamin E. Inanition or mineral deficiency did not seem to play any role. It was shown that a nerve-protecting factor was present in liver and, to a lesser extent, in yeast.In an attempt to discover the nature of this protective factor or factors, further experiments have been carried out in which the basal deficient diet has been supplemented by various crude sources of accessory factors, chiefly various fractions of liver. More recently the newer vitamins, pyridoxine, pantothenic acid and choline have been used in conjunction with thiamin, riboflavin and nicotinic acid. It is the purpose of this report to give an account of the observations dealing with crude substances. Particular interest attaches to the nerve-protecting value of different fractions of liver, for degeneration similar to that observed in the pigs occurs in many cases of pernicious anemia in man. The fractions of liver used were those I

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Section: Discussionmentioning

confidence: 99%

The Prevention of Sensory Neuron Degeneration in the Pig, With Special Reference to the Rôle of Various Liver Fractions 1

Wintrobe¹,

Mushatt²,

Kolb³

et al. 1942

J. Clin. Invest.

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“…Puppies on such a diet develop a hypochromic anemia which responds specifically to pyridoxine (6). Swine also develop anemia, but in addition have epileptiform seizures and abnormalities of gait accompanied by lesions of the central nervous system (7).…”

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confidence: 99%

Pyridoxine Deficiency in Human Beings Induced With Desoxypyridoxine 1

Mueller¹,

Vilter²

1950

J. Clin. Invest.

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In 1934 Gybrgy (1.) announced the existence of an essential vitamin for the rat which was distinct from vitamins B1 and B2. He called it the "antiacrodynia" factor. For a while it carried the name "Adermin" because rats deficient in this substance developed dermatitis, but after its synthesis in 1939 by Harris and Folkers (2) it was renamed pyridoxine. Thereafter numerous reports appeared concerning deficiency states in various animals deprived of this essential nutrient. Deprivation experiments in human beings have not produced clear-cut clinical results and human pyridoxine requirements are unknown.

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“…Brain does not conserve vitamin B-6 as well as muscle during severe dietary vitamin B-6 deficiency. Early studies of vitamin B-6 deficiency reported seizures in dogs (Fouts et al 1938), pigs (Chick et al 1938) and rats (Chick et al 1940). In humans seizures have been observed as a result of dietary vitamin B-6 deficiency (Coursin 1955) and genetic disorders of vitamin B-6 metabolism (Footitt et al 2013;Dakshinamurti and Dakshinamurti 2014).…”

Section: Vitamin B-6 and Seizuresmentioning

confidence: 99%

Vitamin B-6 Metabolism and Interactions with TNAP

Coburn

2015

Subcellular Biochemistry

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Production of Microcytic Hypochromic Anemia in Puppies on Synthetic Diet Deficient in Rat Antidermatitis Factor (Vitamin B6)

Cited by 53 publications

References 9 publications

The Prevention of Sensory Neuron Degeneration in the Pig, With Special Reference to the Rôle of Various Liver Fractions 1

The Prevention of Sensory Neuron Degeneration in the Pig, With Special Reference to the Rôle of Various Liver Fractions 1

Pyridoxine Deficiency in Human Beings Induced With Desoxypyridoxine 1

Vitamin B-6 Metabolism and Interactions with TNAP

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