NICOTINIC ACID TREATMENT IN PELLAGRA 405jections with vitaminized or non-vitaminized horse serum. In all cases stimulation of precipitin-production was noted, the contrast being practically identical with those recorded in Fig. 1.In other groups the method of injection was varied by injecting the horse serum and ascorbic acid separately, such as at different times in the same ear vein, or in different veins, or by giving horse serum intravenously and vitamin C intraiibdominally. Stimulation of specific-precipitin production was noted by all of these technics, confirming the conclusions of Burky' and of Swift and Schultz' in their studies of the immuno-"synergic"$ effects of staphylococcal toxin. The antibody-stimulation, however, was less pronounced in these separate injections than those previously obtained by mixing the horse serum and ascorbic acid before injection.The relative efficiency of ascorbic acid and its sodium salt was also compared in small groups of animals. Sodium ascorbate prepared by Sollmann's technic' was found to be but about half as effective as unneutralized ascorbic acid. Sodium ascorbate, however, is apparently unstable, a commercial preparation tested on a small group of rabbits being without demonstrable antibody-stimulating effect.Pellagrins can be cured while on a maize diet by the oral administration of a filtrate of liver which contains the so-called "filtrate factor" but which is free from riboflavin and rat antidermatitis factor.'

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