Production of microparticles with gelatin and chitosan

Prata, Ana Silvia; Grosso, Carlos Raimundo Ferreira

doi:10.1016/j.carbpol.2014.03.056

Cited by 81 publications

(56 citation statements)

References 32 publications

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“…Materials of natural origin are noteworthy targets for further innovation in biomedical field, which solely rely on the development of different forms of natural polymeric biomaterials [1][2][3]. The utilization of natural polymeric biomaterials has shown superiority in biomedical applications since they have shown better compatibility with the native extracellular matrix (ECM) [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Milled non-mulberry silk fibroin microparticles as biomaterial for biomedical applications

Bhardwaj

Rajkhowa

Wang

et al. 2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

“…The utilization of natural polymeric biomaterials has shown superiority in biomedical applications since they have shown better compatibility with the native extracellular matrix (ECM) [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Milled non-mulberry silk fibroin microparticles as biomaterial for biomedical applications

Bhardwaj

Rajkhowa

Wang

et al. 2015

International Journal of Biological Macromolecules

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“…However, there is quite different where capsule produce in this study are much smaller in size, since [39] applied gelatin-arabic gum system as wall material. This statement was supported by [24] which claimed capsules produced by ChitosanGelatin (B) system (30 Pm approximate diameter) are much smaller than those produced from Gelatin-Arabic gum system (100 Pm approximate diameter). It might be due to the different in viscosity between these two types of complex system where Chitosan-Gelatin (B) system may be less viscous compared to Gelatin-Arabic gum system.…”

Section: Ft-ir Spectramentioning

confidence: 87%

“…Both wall material solutions were prepared according to [24], where solutions of 1% (w/v) gelatin-B (Gel-B) solution were prepared by 30 minutes soaking the protein in DIW prior to 1 hour stirring at 50qC until fully dissolved. Whereas 1% (w/v) chitosan (Chi) solutions were prepared by dissolving analogous amount of Chi in 1% (v/v) CH 3 COOH aqueous solution for more than 12 hours at room temperature.…”

Section: Designing Wall Ratio and Operating Phmentioning

confidence: 99%

“…The transparency decreased when these two polymers were mixed together forming turbid or cloudy mixture as pH increased. In this case, turbidity represents the formation of insoluble complexes and causing increase in absorbance [24]. Since transmittance having opposite relationship with concentration and absorbance, thus when transmittance is low, the turbidity will be high [32].…”

Section: Co Capsules Product Collection and Analysismentioning

confidence: 99%

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Microencapsulation of citronella oil by complex coacervation using chitosan-gelatin (b) system: operating design, preparation and characterization

et al. 2016

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Abstract. Citronella oil (CO) can be an effective mosquito repellent, but due to its nature which having high volatility, oils rapidly evaporates causing loss of efficacy and shorten the repellent effect. Therefore, microencapsulation technology was implemented to ensure the encapsulated material being protected from immediate contact with environment and offers controlled release. In this study, microencapsulation of CO was done by employing complex coacervation using chitosan-gelatin (B) system and utilized proanthocyanidins as the crosslinker. Remarkably, nearly all material involved in this study are from natural sources which are safe to human and environment. In designing operating process condition for CO encapsulation process, we found that wall ratio of 1:35 and pH 5 was the best operating condition based on zeta potential and turbidity analysis. FT-IR analysis found that gelatin-B had coated the CO droplet during emulsification stage, chitosan started to interact with gelatin-B to form a polyelectrolyte complex in adjust pH stage, CO capsules solidified at cooling process and were hardened during crosslinking process. Final product of CO capsules after settling process was identified at the top layer. Surface morphology of CO capsules obtained in this study were described having diameter varies from 81.63 Pm to 156.74 Pm with almost spherical in shape.

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