Production of omega-3 polyunsaturated fatty acid concentrates: A review

Rubio-Rodríguez, Nuria; Beltrán, Sagrario; Jaime, Isabel; Diego, Sara M. de; Sanz, Marı́a Teresa; Carballido, Jordi Rovira

doi:10.1016/j.ifset.2009.10.006

Cited by 413 publications

(273 citation statements)

References 143 publications

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“…An alternative process is extraction with supercritical CO 2 , an environmentally friendly method that avoids the risk of thermal degradation and the presence of toxic residues in the product, since CO 2 is a non-toxic and nonflammable solvent which is easily separated from the extract and ideal for obtaining thermally labile compounds for its moderate supercritical conditions. This technique uses the solvation and transport properties of the supercritical CO 2 to favor the separation of further components by changes in temperature and pressure that modify CO 2 density and solute solubility in the CO 2 (Shahidi, 2005;Follegatti-Romero et al, 2009;Rubio-Rodríguez et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Supercritical CO2 extraction of oil and omega-3 concentrate from Sacha inchi (Plukenetia volubilis L.) from Antioquia, Colombia

2017

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SUMMARY:Sacha inchi (Plukenetia volubilis L.) seeds were employed for oil extraction with supercritical CO 2 at laboratory scale. The supercritical extraction was carried out at a temperature of 60 °C, pressure range of 400-500 bars and CO 2 flow of 40-80 g/min. The maximum recovery was 58% in 180 min, favored by increasing the residence time of CO 2 in the extraction tank. Subsequently, the process was evaluated at pilot scale reaching a maximum recovery of 60% in 105 min, with a temperature of 60 °C, pressure of 450 bars and CO 2 flow of 1270 g/min. The fatty acid composition of the oil was not affected for an extraction period of 30-120 min. The Sacha inchi oil was fractionated with supercritical CO 2 to obtain an omega-3 concentrate oil without finding a considerable increase in the proportion of this compound, due to the narrow range in the carbon number of fatty acids present in the oil (16-18 carbons), making it difficult for selective separation. KEYWORDS: a -linolenic acid; Omega-3; Sacha inchi; Supercritical extractionRESUMEN: Extracción con CO 2 supercrítico de aceite y un concentrado de omega-3 a partir de Sacha inchi (Plukenetia volubilis L.) proveniente de Antioquia, Colombia. Semillas de Sacha inchi fueron empleadas para la extracción de su aceite con CO 2 supercrítico a escala de laboratorio, a una temperatura de 60 °C, entre 400-500 bares de presión y un flujo de CO 2 entre 40-80 g/min, obteniendose una recuperación máxima del 58% en 180 min favorecida por el aumento en el tiempo de residencia del CO 2 en el tanque de extracción. Posteriormente, se evaluó el proceso a escala piloto, alcanzando una recuperación máxima del 60% en 105 min de extracción, a una temperatura de 60 °C, presión de 450 bares y flujo de CO 2 de 1270 g/min, sin afectar la composición de los ácidos grasos del aceite durante un periodo de extracción entre 30-120 min. El aceite de Sacha inchi fue fraccionado con CO 2 supercrítico para la obtención de un aceite concentrado de omega-3, sin encontrar aumento considerable en la proporción de este compuesto debido al estrecho rango en el número de carbonos (16-18 carbonos) de los ácidos grasos presentes en el aceite, lo que dificulta su separación selectiva.

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Section: Introductionmentioning

confidence: 99%

Supercritical CO2 extraction of oil and omega-3 concentrate from Sacha inchi (Plukenetia volubilis L.) from Antioquia, Colombia

2017

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“…Considering the important physiological functions of ω-3 PUFAs, dietary intake of these long-chain fatty acids is indispensable. Fish oil is the primary source of these essential polyunsaturated fatty acids as it contains ω-6 (0.9-12 g.100 g -1 oil) and ω-3 (11.9-35.3 g.100 g -1 oil) (VenegasCaleron et al, 2010;Rubio-Rodriguez et al, 2010). However, over-fishing, environmental pollution and a costly manufacturing process have resulted in fish oil not being the optimal choice nowadays.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and oxidative evolution of Sacha Inchi (Plukentia volubilis L.) oil from Xishuangbanna (China)

Liu

Zhang

et al. 2014

Grasas y Aceites

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SUMMARY: Sacha Inchi oil was studied for its physicochemical characteristics, chemical composition, radical scavenging activity and storage stability. The fatty acid composition was studied by gas chromatography-flame ionization (GC-FID) and the analysis showed that the oil is highly enriched in a-linolenic (43.5%) and linoleic (39.6%) acids. The tocopherol content in the oil analyzed by high performance liquid chromatography/ ultraviolet-visible detector (HPLC/UV-VIS) was also high (161.87 mg.100 g -1). Both DPPH and ABTS assays detected relatively high radical scavenging activity. After twelve months of storage, the oil showed relatively good storage stability. The results will help guide further investigation of the health benefits of Sacha Inchi oil for the population and the development of better edible oil products and nutraceuticals. ). Los ensayos de DPPH y ABTS detectaron actividad captadora de radicales relativamente alta. Tras doce meses de almacenamiento los aceites mostraron una relativamente buena estabilidad. Los resultados ayudarán a orientar investigación adicional sobre los beneficios para la salud del aceite de Sacha Inchi para la población y al desarrollo de mejores productos de aceites comestibles y nutracéuticos.

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“…Microalgae, the primary producers of EPA and DHA in the marine food chain, can produce long chain omega-3 fatty acids, and naturally grow under a variety of autotrophic, mixotrophic, and heterotrophic culture conditions (RubioRodríguez et al 2010). Autotrophic and mixotrophic microalgae fix atmospheric carbon dioxide during photosynthesis, can grow on non-arable land, and have short harvesting times (Rubio-Rodríguez et al 2010;Schenk et al 2008). A comparison of EPA and DHA sources revealed that microalgae are able to produce greater quantities of EPA and DHA than the other common sources.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 fatty acid obtained from Nannochloropsis oceanica cultures grown under low urea protect against Abeta-induced neural damage

Lai

2014

J Food Sci Technol

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Amyloid-beta (Abeta) protein is a key factor in the pathogenesis of Alzheimer's disease (AD). Moreover, it has been reported that oxidative stress is involved in the biochemical pathway by which Abeta can lead to neuronal dysfunction. Recently, docosahexaenoic acid (DHA; C22:6) and eicosapentaenoic acid (EPA; C20:5n-3) have been reported to protect against AD. However, these omega-3 fatty acids are frequently obtained from fish oil and may contain heavy metals. In this study, we utilized Nannochloropsis oceanica to produce omega-3 fatty acid. We observed that when urea levels (nitrogen source) were lowered from 2 to 0.2 g/L in Nannochloropsis oceanica cultures, EPA production increased. Moreover, EPA in Nannochloropsis oceanica effectively promoted antioxidant activity to counter the Abetainduced oxidative stress in Neuro-2A cells. These results indicate that Nannochloropsis oceanica may be potentially used as a therapeutic agent or as a functional food that promotes protection against AD.

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Production of omega-3 polyunsaturated fatty acid concentrates: A review

Cited by 413 publications

References 143 publications

Supercritical CO<sub>2</sub> extraction of oil and omega-3 concentrate from Sacha inchi (<em>Plukenetia volubilis</em> L.) from Antioquia, Colombia

Supercritical CO<sub>2</sub> extraction of oil and omega-3 concentrate from Sacha inchi (<em>Plukenetia volubilis</em> L.) from Antioquia, Colombia

Chemical composition and oxidative evolution of Sacha Inchi (<em>Plukentia volubilis</em> L.) oil from Xishuangbanna (China)

Omega-3 fatty acid obtained from Nannochloropsis oceanica cultures grown under low urea protect against Abeta-induced neural damage

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