Production of penicillic acid by Aspergillus sclerotiorum CGF

Kang, Suzie; Park, C.H.; Hong, Seongjin; Kim, Seung Wook

doi:10.1016/j.biortech.2005.11.033

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…Since, the discovery of penicillin, the micromycetes have been famous as producers of antibiotics and other secondary metabolites with biological activity (Rancic et al, 2006). Penicillium sp have been proved as being abundant producers of many bioactive secondary metabolites/mycotoxins (Nicoletti et al, 2014) like citrinin and penicillic acid has shown potent antimicrobial activity (Kang et al, 2007; Yu et al, 2010). Presently, Penicillium sp.…”

Section: Discussionmentioning

confidence: 99%

Larvicidal, Histopathological, Antibacterial Activity of Indigenous Fungus Penicillium sp. Against Aedes aegypti L and Culex quinquefasciatus (Say) (Diptera: Culicidae) and Its Acetylcholinesterase Inhibition and Toxicity Assessment of Zebrafish (Danio rerio)

et al. 2019

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Fungal metabolites are considered to be most efficient tools to overcome the issues related to insecticide resistance and environmental pollution. The present study focus on the evaluation of the mosquito larvicidal efficacy of metabolites of seven indigenous fungal isolates (Penicillium sp. Aspergillus niger, A. flavus, A. parasiticus, Rhizopus sp. Mucor sp. and Aspergillus sp.) on the larvae of Aedes aegypti and Culex quinquefasciatus under the laboratory condition. The preliminary screening of the isolate, Penicillium sp. showed better larvicidal effect when compared to other fungi. The fungus was grown on Potato Dextrose Broth (PDB) in the laboratory (at 25°C) and maintained in the relative humidity (at 76 ± 4% for 15 days). Larvicidal potency of mycelial ethyl acetate extract (MEAE) of Penicillium sp. was performed against 1st to 4th instars larvae of Ae. aegypti and Cx. quinquefasciatus using four different concentrations (100, 200, 300, and 500 μg/ml) that showed better larval mortality values (μg/ml) of LC50 = 6.554, 5.487, 6.874, 6.892, and the LC90 = 11.486, 10.366, 12.879, 13.865 for Ae. aegypti and LC50 = 7.000, 13.943, 18.129, 25.212 and the LC90 = 12.541, 23.761, 30.923, 41.696 for Cx. quinquefasciatus. Exposure of metabolite to larvae resulted in behavior changes i.e., excitation, up and down with aggressive movement, anal papillae biting behavior. Further, the larvae treated with Penicillium sp. metabolite exhibited significant reduction in the levels of acetylcholinesterase. The 4th instar mosquito larvae treated with the 500 μg/ml mycelia extract showed severe histological damages. During the antibacterial analysis of Penicillium sp.- mycelium the maximum growth inhibition zone was recorded in Shigella dysenteriae (31.2 mm) and Klebsiella pneumoniae (31.1 mm) followed by others. In addition, to check the toxicity of Penicillium sp. MEAE against embryos of Zebrafish, a model system, using different concentrations of metabolites (1.0, 0.5, 0.125 mg/ml, 30, 3.0, and 0.5 μg/ml) and life-stage parameters were observed at 124 hpf. Furthermore, the Fourier Transformed Infrared and GCMS spectrum analysis of mycelium reflected several chemical compounds. The outcome of the study clearly shows that Penicillium sp. metabolites could serve as an ideal eco-friendly, single-step and inexpensive source for the control of Ae. aegypti and Cx. quinquefasciatus larvae.

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Section: Discussionmentioning

confidence: 99%

Larvicidal, Histopathological, Antibacterial Activity of Indigenous Fungus Penicillium sp. Against Aedes aegypti L and Culex quinquefasciatus (Say) (Diptera: Culicidae) and Its Acetylcholinesterase Inhibition and Toxicity Assessment of Zebrafish (Danio rerio)

et al. 2019

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“…Many fungi have been reported to be producers of PA, including the genus Penicillium and Aspergillus [113,114]. PA had been isolated from the following Penicillium species: P. viridicatum [115].…”

Section: Producing Fungal Speciesmentioning

confidence: 99%

“…Different Eupenicillium species such as E. bovifimosum, E. baarnese were also found to produce PA [120,121]. PA had been also produced by Aspergillus species such as: A. ochraceus [122], A. auricomus, A. melleus [119], A. alliaceus [123], A. ostianus [124], A. cervinus, A. wentii [109] and A. sclerotiorum [114]. The large number of strains capable of elaborating the mycotoxin PA indicates the ubiquity of penicillic acid-producing organisms in nature and the possibility for presence of this mycotoxin in stored high-moisture grains [119].…”

Section: Producing Fungal Speciesmentioning

confidence: 99%

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

2015

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Abstract:Mycotoxins are secondary fungal metabolites, toxic to humans, animals and plants. Among the hundreds of known mycotoxins, aflatoxins, citrinin, patulin, penicillic acid, tenuazonic acid, ochratoxin A, cytochalasins, deoxynivalenol, fumonisins, fusarin C, fusaric acid, and zearalenone are considered the types that most contaminate cereal grain. The majority of the mycotoxins in these groups are produced by three fungal genera: Aspergillus, Penicillium and Fusarium. These metabolites primarily affect the seed quality, germination, viability, seedling vigour, growth of root and cleoptile. Additionally, since the fungi responsible for the production of these mycotoxins are often endophytes that infect and colonize living plant tissues, accumulation of mycotoxins in the plant tissues may at times be associated with development of plant disease symptoms. The presence of mycotoxins, even in the absence of disease symptoms, may still have subtle biological effects on the physiology of plants. Several studies highlight the toxic effects of mycotoxins on animals and cell lines but little is known about the mode of action of most of these metabolites on plant cells. The most important mycotoxins with phytotoxic effects and their producers in addition to their discovery are briefly outlined below and will be addressed in this article.

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“…Furthermore, moniliformin is produced by isolates of Fusarium fusaroides from millet, sorghum, dried fish and peanuts (Rabie et al, 1978). In addition Fusarium species produce several other mycotoxins concomitantly, such as trichothecenes, zearalenone, Visagie et al, 2014a Aspergillus ochraceus Ciegler, 1972;El-Shanawany et al, 2005;Frisvad et al, 2004a;Garza et al, 1993;Northolt et al, 1979;Obana et al, 1995b;Visagie et al, 2014a Aspergillus ostianus Ciegler, 1972;Frisvad et al, 2004a;Namikoshi et al, 2003;Obana et al, 1995b; Frisvad et al, 2004a;Visagie et al, 2014a Aspergillus sclerotiorum Ciegler, 1972;Frisvad et al, 2004a;Kang and Kim, 2004;Kang et al, 2007;Obana et al, 1995b;Visagie et al, 2014a;Zheng et al, Bridge et al 1989;Bokhari and Flannigan, 1996;El-Banna et al, 1987;Frisvad and Filtenborg 1983;Frisvad et al, 2004b;Garza et al, 1993;Khaddor et al, 2007;Lund and Frisvad 1994;Mills et al, 1995a,b;Oh et al, 1998 Penicillium aurantiogriseum var. polonicum Frisvad and Filtenborg, 1989 see P. polonicum Penicillium aurantiogriseum var.…”

Section: Moniliformin and Producing Microorganismsmentioning

confidence: 99%

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

Frisvad

2018

WMJ

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A very large number of filamentous fungi has been reported to produce the small lactone mycotoxins patulin, penicillic acid and moniliformin. Among the 167 reported fungal producers of patulin, only production by 29 species could be confirmed. Patulin is produced by 3 Aspergillus species, 3 Paecilomyces species, 22 Penicillium species from 7 sections of Penicillium, and one Xylaria species. Among 101 reported producers of penicillic acid, 48 species could produce this mycotoxin. Penicillic acid is produced by 23 species in section Aspergillus subgenus Circumdati section Circumdati, by Malbranchea aurantiaca and by 24 Penicillium species from 9 sections in Penicillium and one species that does not actually belong to Penicillium (P. megasporum). Among 40 reported producers of moniliformin, five species have been regarded as doubtful producers of this mycotoxin or are now regarded as taxonomic synonyms. Moniliformin is produced by 34 Fusarium species and one Penicillium species. All the accepted producers of patulin, penicillic acid and moniliformin were revised according to the new one fungus – one name nomenclatural system, and the most recently accepted taxonomy of the species.

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Production of penicillic acid by Aspergillus sclerotiorum CGF

Cited by 9 publications

References 7 publications

Larvicidal, Histopathological, Antibacterial Activity of Indigenous Fungus Penicillium sp. Against Aedes aegypti L and Culex quinquefasciatus (Say) (Diptera: Culicidae) and Its Acetylcholinesterase Inhibition and Toxicity Assessment of Zebrafish (Danio rerio)

Larvicidal, Histopathological, Antibacterial Activity of Indigenous Fungus Penicillium sp. Against Aedes aegypti L and Culex quinquefasciatus (Say) (Diptera: Culicidae) and Its Acetylcholinesterase Inhibition and Toxicity Assessment of Zebrafish (Danio rerio)

Mycotoxins: Producing Fungi and Mechanisms of Phytotoxicity

A critical review of producers of small lactone mycotoxins: patulin, penicillic acid and moniliformin

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