2009
DOI: 10.1002/elsc.200800100
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Production of Pharmaceuticals from Papaver Cultivars in Vitro

Abstract: Iranian (Papaver bracteatum Lindl.) and opium poppy (P. somniferum L.) plantlets obtained from germinated seeds grown on a Murashige and Skoog basal medium (BM) readily manifest alkaloids. Temperature had a profound effect on growth and alkaloid production after 8 weeks in culture. Plantlets of poppy cultivars (cvs.) grew best at 18.5 and 20°C compared to 15 or 25°C. An alkaloid survey study with 24 Iranian and 21 opium poppy cvs. revealed that total morphinan alkaloids ranged from 0 to 6.55 mg/g dw. Prolific … Show more

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Cited by 28 publications
(7 citation statements)
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“…Latex contained all the five alkaloids measured in the analysis. Content of specific alkaloids is similar to as reported by our ) and other groups (Tisseral and Berhow 2009;Frick et al 2005). Likewise, the accumulation of secondary metabolites was significantly higher in field grown plants than in embryogenic and non embryogenic callus cultures.…”
Section: Alkaloid Accumulation In Field Grown Plantssupporting
confidence: 89%
“…Latex contained all the five alkaloids measured in the analysis. Content of specific alkaloids is similar to as reported by our ) and other groups (Tisseral and Berhow 2009;Frick et al 2005). Likewise, the accumulation of secondary metabolites was significantly higher in field grown plants than in embryogenic and non embryogenic callus cultures.…”
Section: Alkaloid Accumulation In Field Grown Plantssupporting
confidence: 89%
“…The cell biomass of the suspension culture was harvested 12 and 16 days after culture initiation and freezedried. Alkaloids of 1.5-2 g dried cells were extracted by the acidic methanol method (Tisserat and Berhow, 2009) with few modifications. Eight milliliters of extraction solution consisting of 40% methanol, 59.5% water, and 0.5% acetic acid was added to samples, followed by sonication for 12 min.…”
Section: Sample Preparation and Hplc Analysis Of Thebainementioning
confidence: 99%
“…Thebaine is a precursor of codeine which is converted to codeine and simultaneously to morphine. Because of the low activity of enzymes involved in demethylation of codeine and morphine, the yields of codeine and morphine is low in Papaver bracteatum [126]. Latex from the opium poppy (P. somniferum) is a commercial source of the analgesics, morphine and codeine.…”
Section: Plant Name Active Ingredient Culture Type Referencesmentioning
confidence: 99%