Production of Polyhydroxyalkanoates and Extracellular Products Using Pseudomonas Corrugata and P. Mediterranea: A Review

Licciardello, Grazia; Catara, A.; Catara, Vittoria

doi:10.3390/bioengineering6040105

Cited by 32 publications

(21 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, an integrated process is presented in this review to conveniently recover intracellular mcl-PHA by the halogen-free solvent acetone and bioactive EPS by chloroform/methanol mixtures. Moreover, available transcriptional regulation studies during PHA production contribute to better understand the metabolic potential of P. corrugata and P. mediterranea strains; here, the available data suggest that regulating of PHA biosynthesis genes will enable to develop new, integrated strategies for cost-effective mcl-PHA and EPS production in the future [16].…”

Section: Individual Contributionsmentioning

confidence: 97%

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

Koller

2020

Bioengineering

View full text Add to dashboard Cite

During the two years that have passed since the first volume of “Advances in Polyhydroxyalkanoate (PHA) production” was published, the progress in PHA-related research was indeed tremendous, calling for the next, highly bioprocess- and bioengineering-oriented volume. This editorial paper summarizes and puts into context the contributions to this second volume of the Bioengineering Special Issue; it covers highly topical fields of PHA-related R&D activities, covering, beside the pronounced bioengineering-related articles, the fields of the microbiology of underexplored, but probably emerging, PHA production strains from the groups of Pseudomonas, cyanobacteria, methanotrophs, and from the extremophilic domain of haloarchaea. Moreover, novel second-generation lignocellulose feedstocks for PHA production from agriculture to be used in biorefinery concepts, new approaches for fine-tuning the composition of PHA co- and terpolyesters, process simulation for PHA production from methane-rich natural gas, the challenges associated with rheology-governed oxygen transfer in high cell density cultivations, rapid spectroscopic in-line analytics for process monitoring, and the biomedical application of PHA biopolyesters after appropriate advanced processing are the subjects of the presented studies.

show abstract

Section: Individual Contributionsmentioning

confidence: 97%

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

Koller

2020

Bioengineering

View full text Add to dashboard Cite

show abstract

“…As several biopolymers belong to the PHA family, their classification is important, and they can be sorted depending on their chain-length monomeric composition, according to the number of carbon atoms per monomer, and here a great importance is played by the composition of the monomer side chain R [ 14 ]: Short-chain-length PHA (scl-PHA) has three to five carbon atoms; Medium-chain-length PHA (mcl-PHA) has 6 to 14 carbon atoms; Long-chain-length PHA (lcl-PHA) has more than 14 carbon atoms. …”

Section: Pha: Biosynthesis and Propertiesmentioning

confidence: 99%

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

et al. 2021

View full text Add to dashboard Cite

In recent years, biopolymers have been attracting the attention of researchers and specialists from different fields, including biotechnology, material science, engineering, and medicine. The reason is the possibility of combining sustainability with scientific and technological progress. This is an extremely broad research topic, and a distinction has to be made among different classes and types of biopolymers. Polyhydroxyalkanoate (PHA) is a particular family of polyesters, synthetized by microorganisms under unbalanced growth conditions, making them both bio-based and biodegradable polymers with a thermoplastic behavior. Recently, PHAs were used more intensively in biomedical applications because of their tunable mechanical properties, cytocompatibility, adhesion for cells, and controllable biodegradability. Similarly, the 3D-printing technologies show increasing potential in this particular field of application, due to their advantages in tailor-made design, rapid prototyping, and manufacturing of complex structures. In this review, first, the synthesis and the production of PHAs are described, and different production techniques of medical implants are compared. Then, an overview is given on the most recent and relevant medical applications of PHA for drug delivery, vessel stenting, and tissue engineering. A special focus is reserved for the innovations brought by the introduction of additive manufacturing in this field, as compared to the traditional techniques. All of these advances are expected to have important scientific and commercial applications in the near future.

show abstract

“…PHAs, which possess properties similar to the conventional petrochemical polymers, are usually produced by bacterial and archaeal fermentation in conditions of nutrient depletion or excess of carbon sources and are accumulated within their cytoplasm (Chen, 2010;Rodriguez-Contreras, 2019). PHA family members differ widely in their structure and properties depending on the type of microorganism, biosynthesis conditions, and on which carbon source was used during the production process (Licciardello et al, 2019;Mozejko-Ciesielska et al, 2019).…”

Section: Polyestersmentioning

confidence: 99%

Natural-Based Biomaterials for Peripheral Nerve Injury Repair

Fornasari

Carta

Gambarotta

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Peripheral nerve injury treatment is a relevant problem because of nerve lesion high incidence and because of unsatisfactory regeneration after severe injuries, thus resulting in a reduced patient's life quality. To repair severe nerve injuries characterized by substance loss and to improve the regeneration outcome at both motor and sensory level, different strategies have been investigated. Although autograft remains the gold standard technique, a growing number of research articles concerning nerve conduit use has been reported in the last years. Nerve conduits aim to overcome autograft disadvantages, but they must satisfy some requirements to be suitable for nerve repair. A universal ideal conduit does not exist, since conduit properties have to be evaluated case by case; nevertheless, because of their high biocompatibility and biodegradability, natural-based biomaterials have great potentiality to be used to produce nerve guides. Although they share many characteristics with synthetic biomaterials, natural-based biomaterials should also be preferable because of their extraction sources; indeed, these biomaterials are obtained from different renewable sources or food waste, thus reducing environmental impact and enhancing sustainability in comparison to synthetic ones. This review reports the strengths and weaknesses of natural-based biomaterials used for manufacturing peripheral nerve conduits, analyzing the interactions between natural-based biomaterials and biological environment. Particular attention was paid to the description of the preclinical outcome of nerve regeneration in injury repaired with the different natural-based conduits.

show abstract

Production of Polyhydroxyalkanoates and Extracellular Products Using Pseudomonas Corrugata and P. Mediterranea: A Review

Cited by 32 publications

References 55 publications

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

Advances in Polyhydroxyalkanoate (PHA) Production, Volume 2

Advantages of Additive Manufacturing for Biomedical Applications of Polyhydroxyalkanoates

Natural-Based Biomaterials for Peripheral Nerve Injury Repair

Contact Info

Product

Resources

About