Production of pyocyanin pigment from Pseudomonas aeruginosa strains and investigation of the antimicrobial effect of pyocyanin on other microorganisms

Özyürek, Sezen Bilen; Gür, Sinem Diken; Bilkay, Işıl Seyis

doi:10.1016/j.copbio.2011.05.363

Cited by 7 publications

(5 citation statements)

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“…aeruginosa, a Gram-negative opportunistic human pathogen, produces biosurfactants which belong to rhamnolipids for colonization (Perfumo et al, 2006;Arutchelvi and Doble, 2010;Müller et al 2010) and toxins, including pigment like blue-green pyocyanin, to kill other competitor microorganisms (Norman et al, 2004;Ozyurek et al, 2011). While biosurfactants are used in textile industries, leather processing, in bioremediation, agriculture, and in the food and beverage industry (Coelho et al, 2010), pyocyanin can be exploited against other pathogens to reduce crude oil degradation (Norman et al, 2004) and for quantifying ammonium ion concentration (Iida and Satoh, 2013).…”

Section: Introductionmentioning

confidence: 99%

EFFECTS OF CULTIVATION MEDIA COMPONENTS ON BIOSURFACTANT AND PIGMENT PRODUCTION FROM Pseudomonas aeruginosa PAO1

Das

2015

Braz. J. Chem. Eng.

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-Biosurfactant and pigment production by P. aeruginosa have been known to be associated with its selfish growth and colonization. However, according to recent studies these products can be exploited for human benefits. In the present work the effects of culture media components on yield of these two products from P. aeruginosa PAO1 have been studied with statistical screening design experiments. Biosurfactant yield was found to be increased by two times in a modified medium. This study will help in further modifying the media composition for cheaper media development, kinetic modelling and fermentation strategy development.

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Section: Introductionmentioning

confidence: 99%

EFFECTS OF CULTIVATION MEDIA COMPONENTS ON BIOSURFACTANT AND PIGMENT PRODUCTION FROM Pseudomonas aeruginosa PAO1

Das

2015

Braz. J. Chem. Eng.

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“…The results were consistent with our previous study [ 20 ]. As for singly cultured P. aeruginosa and the co-cultured system, P. aeruginosa secreted a number of phenazine compounds, including green pyocyanin [ 41 ]. Figure 5c displays that the biofilm of singly cultured P. aeruginosa and co-cultured system was pale green, suggesting the presence of pyocyanin.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using an in vitro multispecies biofilm model

Zhang

Chen

et al. 2021

Regenerative Biomaterials

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Chronic wounds are a serious worldwide problem, which are often accompanied by wound infections. In this study, bacterial cellulose (BC)-based composites introduced with tannic acid (TA) and magnesium chloride (BC-TA-Mg) were fabricated for anti-biofilm activities. The prepared composites' surface properties, mechanical capacity, thermal stability, water absorption and retention property, releasing behavior, anti-biofilm activities, and potential cytotoxicity were tested. Results show that TA and MgCl2 particles closely adhered to the nanofibers of BC membranes, thus increasing surface roughness and hydrophobicity of the membranes. While the introduction of TA and MgCl2 did not influence the transparency of the membranes, making it beneficial for wound inspection. BC-TA and BC-TA-Mg composites displayed increased tensile strength and elongation at break compared to pure BC. Moreover, BC-TA-Mg exhibited higher water absorption and retention capacity than BC and BC-TA, suitable for the absorption of wound exudates. BC-TA-Mg demonstrated controlled release of TA and good inhibitory effect on both singly-cultured S. aureus and P. aeruginosa biofilm and co-cultured biofilm of S. aureus and P. aeruginosa. Furthermore, the cytotoxicity grade of BC-TA-6Mg membrane was eligible based on standard toxicity classifications. These indicated that BC-TA-Mg is potential to be used as wound dressings combating biofilms in chronic wounds.

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“…The Rhl system controls the synthesis of P. aeruginosa surfactants (rhamnolipids), which is involved in the killing of S. aureus by P. aeruginosa 22 and growth modulation of Burkholderia cepacia complex 23 . Pyocyanin from P. aeruginosa is an antimicrobial agent against other competitors 24 . Activation of such virulence factors by the Fem system may potentially benefit P. aeruginosa in inter-species competition 25 .…”

Section: Discussionmentioning

confidence: 99%

The Fem Cell-surface Signaling System is Regulated by ExsA inPseudomonas aeruginosaand Affects Pathogenicity

Li,

Badr,

Zhang

et al. 2024

Preprint

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Bacterial interspecies interactions shape the function and the structural dynamics of microbial communities and affect the progression of polymicrobial infections. The FemA-FemR-FemI (Fem) cell surface signaling system inPseudomonas aeruginosais known to be involved in the uptake of iron-chelating mycobactin produced by theMycobacteriumspecies. In this report, we present the data that indicates thefemA-PA1909 operon was positively regulated by ExsA, a master regulator for the type three secretion system (T3SS), connecting the Fem system with T3SS. Intriguingly, the Fem system also influenced virulence factors inP. aeruginosa,including the quorum sensing systems, pyocyanin production, biofilm formation and the type six secretion systems (T6SSs). Using aGalleria mellonellainfection model we observed that anfemAdeletion in PAO1 significantly increased the host survival rate whilefemIover-expression decreased it, suggesting a role for the Fem system in bacterial pathogenicityin vivo. Our data indicate the Fem system is a target of the T3SS master activator ExsA, and it affectsP. aeruginosapathogenicity.

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Production of pyocyanin pigment from Pseudomonas aeruginosa strains and investigation of the antimicrobial effect of pyocyanin on other microorganisms

Cited by 7 publications

References 0 publications

EFFECTS OF CULTIVATION MEDIA COMPONENTS ON BIOSURFACTANT AND PIGMENT PRODUCTION FROM Pseudomonas aeruginosa PAO1

EFFECTS OF CULTIVATION MEDIA COMPONENTS ON BIOSURFACTANT AND PIGMENT PRODUCTION FROM Pseudomonas aeruginosa PAO1

Evaluation of the anti-biofilm activities of bacterial cellulose-tannic acid-magnesium chloride composites using an in vitro multispecies biofilm model

The Fem Cell-surface Signaling System is Regulated by ExsA inPseudomonas aeruginosaand Affects Pathogenicity

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