Production of Reactive Oxygen Species in Peripheral Blood is Increased in Individuals with <i>Helicobacter pylori</i> Infection and Decreased after its Eradication

Mashimo, Masayuki; Nishikawa, Manabu; Higuchi, Kazuhide; Hirose, Masaki; Qian, Wei; Haque, Anwarul; Sasaki, Eiji; Shiba, Masatsugu; Tominaga, Kazunari; Watanabe, Toshio; Fujiwara, Yasuhiro; Inoue, Masayasu

doi:10.1111/j.1523-5378.2006.00410.x

Cited by 35 publications

(30 citation statements)

References 33 publications

(38 reference statements)

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“…ROS production of the blood samples from H. pylori infected subjects was significantly decreased 2 months after eradication (13). Such evidence included only H. pylori-infected patients with high levels of reactive oxygen species (ROS).…”

Section: Helicobacter Pylori (H Pylori) Is a Gram Negative Bacteriummentioning

confidence: 99%

The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease

et al. 2009

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Section: Helicobacter Pylori (H Pylori) Is a Gram Negative Bacteriummentioning

confidence: 99%

The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease

et al. 2009

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“…The ROS were determined as described previously. 22 Briefly, the blood samples (50 μL) were incubated in 0.5 mL Ca 2+ , Mg 2+ -free Hank's balanced salt solution (HBSS) (Invitrogen, Auckland, NZ) containing 6 mmol/L KCl, and 6 mmol/L MgCl2 in the presence of 90 μmol/L L-012 (Sigma, St. Louis, MO). After incubation for 3 min at 37 C, chemiluminescence intensity was recorded continuously for 20 min using the Photon Counter 23 ; the ROS production was evaluated by the maximal chemiluminescence intensity.…”

Section: Methodsmentioning

confidence: 99%

Oxidative Stress Markers Correlate with Renal Dysfunction and Thrombocytopenia in Severe Leptospirosis

Araújo¹,

Reis²,

Athanazio³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Leptospirosis is a zoonotic disease that causes severe manifestations such as Weil's disease and pulmonary hemorrhage syndrome. The aim of this study was to evaluate whether reactive oxygen species (ROS) production and antioxidant reduced glutathione (GSH) levels are related to complications in patients hospitalized with leptospirosis. The ROS production and GSH levels were measured in blood samples of 12 patients and nine healthy controls using chemiluminescence and absorbance assays. We found that ROS production was higher and GSH levels were lower in leptospirosis patients compared with healthy individuals. Among patients, GSH depletion was correlated with thrombocytopenia and elevated serum creatinine, whereas a strong positive correlation was observed between ROS production and elevated serum potassium. Additional investigation of the biological significance of ROS production and GSH levels is warranted as they may guide the development of novel adjuvant therapies for leptospirosis targeting oxidative stress.

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“…Introduction R edox signaling is increasingly regarded as an important cellular process in a variety of cellular activities, including cell proliferation (50,52,275), differentiation (72,153,219,337,338), and apoptosis (162,242,254,304,413). Redox injury, as a pathological mechanism, is also involved in a wide range of pathophysiological processes such as senescence (65), inflammation (17,264,421), hypoxia (32,148,200,245), and ischemia/reperfusion (126,379,384), which contribute to the progression of almost all diseases, from cardiovascular ones such as shock (94,116,117), hypertension (73,167,288,294,316,440), atherosclerosis (208,297), to metabolic ones such as diabetes mellitus (20,217), neurodegenerative ones such as Alzheimer's disease (AD) (55,305), infectious diseases (184,252,285,375), and cancer (16,…”

mentioning

confidence: 99%

Lipid Raft Redox Signaling: Molecular Mechanisms in Health and Disease

Jin

Zhang

Katirai

et al. 2011

Antioxidants & Redox Signaling

104

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Lipid rafts, the sphingolipid and cholesterol-enriched membrane microdomains, are able to form different membrane macrodomains or platforms upon stimulations, including redox signaling platforms, which serve as a critical signaling mechanism to mediate or regulate cellular activities or functions. In particular, this raft platform formation provides an important driving force for the assembling of NADPH oxidase subunits and the recruitment of other related receptors, effectors, and regulatory components, resulting, in turn, in the activation of NADPH oxidase and downstream redox regulation of cell functions. This comprehensive review attempts to summarize all basic and advanced information about the formation, regulation, and functions of lipid raft redox signaling platforms as well as their physiological and pathophysiological relevance. Several molecular mechanisms involving the formation of lipid raft redox signaling platforms and the related therapeutic strategies targeting them are discussed. It is hoped that all information and thoughts included in this review could provide more comprehensive insights into the understanding of lipid raft redox signaling, in particular, of their molecular mechanisms, spatial-temporal regulations, and physiological, pathophysiological relevances to human health and diseases. Antioxid. Redox Signal. 15, 1043-1083.

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Production of Reactive Oxygen Species in Peripheral Blood is Increased in Individuals with Helicobacter pylori Infection and Decreased after its Eradication

Abstract: These findings suggest that ROS production was enhanced in peripheral blood by H. pylori infection. Chemiluminescence analysis of blood samples using L-012 permits evaluation of systemic oxidative stress in patients with H. pylori infection.

Cited by 35 publications

References 33 publications

The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease

The Influence of Helicobacter pylori Eradication on Leptin, Soluble CD40 Ligand, Oxidative Stress and Body Composition in Patients with Peptic Ulcer Disease

Oxidative Stress Markers Correlate with Renal Dysfunction and Thrombocytopenia in Severe Leptospirosis

Lipid Raft Redox Signaling: Molecular Mechanisms in Health and Disease

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