Production of recombinant lumpy skin disease virus A27L and L1R proteins for application in diagnostics and vaccine development

Ntombela, Nomfundo; Matsiela, Matome; Zuma, Sbahle; Hiralal, Suhavna; Naicker, Leeann; Mokoena, Nobalanda; Khoza, Thandeka

doi:10.1016/j.jvacx.2023.100384

Vaccine: X

2023

DOI: 10.1016/j.jvacx.2023.100384

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Production of recombinant lumpy skin disease virus A27L and L1R proteins for application in diagnostics and vaccine development

Nomfundo Ntombela,

Matome Matsiela,

Sbahle Zuma

et al.

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2024

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Cited by 2 publications

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Lumpy Skin Disease: An Encroaching Risk in Cattle Farming

Afzal,

Umar,

Hussain

et al. 2024

Taiwan Vet J

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Lumpy skin disease (LSD) is a vector-borne disease of cattle and water buffalo caused by the lumpy skin disease virus (LSDV) of the Capripoxvirus genus. LSD mainly affects the skin and the lymphatics of animals, and manifests as firm skin nodules, low feed intake, and a drop in milk production. Animal-to-animal contact, blood-feeding insects, animal products, stable flies, and mosquitoes can facilitate the transmission of LSD across herds and borders. The first case of LSD was reported in 1929 in Zambia. It was endemic to Africa until 1985 and later spread to Eastern Europe and Asia. The latest outbreak of LSD was reported in the Asia-Pacific region. At present, biosafety measures (control of animal movement, vectors, and animal products) are being devised by authorities to tackle LSD. Vaccines are also being developed for LSDV in recent decades. Live attenuated vaccines of both homologous and heterologous (of the Capripoxvirus genus) virus strains were utilized. A few side effects of the live vaccines were observed, such as skin nodules, low feed intake, and a drop in milk production. Inactivated LSDV vaccines were produced, showing a higher safety profile than live vaccines, yet offering only partial protection and lacks cross-protection. Recombinant LSDV vaccines are also under development; however, challenges remain in terms of the best vaccine delivery methods and antigen selection from the large poxvirus genome. Overall, mass vaccination with an effective vaccine may play a central role in the control of LSDV.

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Lumpy Skin Disease: An Encroaching Risk in Cattle Farming

Afzal,

Umar,

Hussain

et al. 2024

Taiwan Vet J

View full text Add to dashboard Cite

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Lumpy Skin Disease: Insights into Molecular Pathogenesis and Control Strategies

Haider,

Abbas,

Taqveem

et al. 2024

Veterinary Sciences

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Lumpy skin disease (LSD) is a viral infection that affects buffaloes and cattle across various regions, including both tropical and temperate climates. Intriguingly, the virus–carrying skin sores remain the primary source of infection for extended periods, exacerbated by the abundance of vectors in disease–endemic countries. Recent scientific advances have revealed the molecular aspects of LSD and offered improved vaccines and valuable antiviral targets. This review summarizes the molecular features of LSD and its effect on various livestock species. We then provide an extensive discussion on the transmission dynamics of LSD and the roles of vectors in its continued spread among livestock populations. Additionally, this review critically analyses the rationales behind, as well as the affordability and effectiveness, of current control strategies worldwide.

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Production of recombinant lumpy skin disease virus A27L and L1R proteins for application in diagnostics and vaccine development

Cited by 2 publications

References 42 publications

Lumpy Skin Disease: An Encroaching Risk in Cattle Farming

Lumpy Skin Disease: An Encroaching Risk in Cattle Farming

Lumpy Skin Disease: Insights into Molecular Pathogenesis and Control Strategies

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