Production of spray dried salbutamol sulphate for use in dry powder aerosol formulation

Isothermal calorimetry: A predictive tool to model drug-propellant interactions in pressurized metered dose systems

“…In comparison, SEM images of SS showed corrugated spherical particles with a similar size distribution to BDP. In general, the SS 200 morphology appeared to be similar to that reported in previous work, which utilised aqueous solutions to spray dry SS (21,22); while the spray-dried BDP particles were similar in morphology to that reported by Abdel-Halim et al (23), wherein particles were prepared from a 20% w/v ethanolic solution . In general, both particulate systems could be considered of a suitable size for inhalation purposes (24), thus making the study of interactions in 205 medical propellants relative to respiratory drug delivery.…”

“…The second round of HPFP perfusion also produced a power-time output that retraced the initial round of perfusion, suggesting that the SS did not undergo any crystallization or chemical change. These observations were further confirmed by qualitative analysis of SEM images of the SS micro-particulates before and after perfusion with HPFP ( Figure 8A and B, respectively) and via X-ray powder ( Figure 8C); where dual 360 broad peaks indicated an amorphous structure typical of spray dried SS (21,33). Thus findings from TAM, O-DVS, SEM and XRPD suggest that SS does not readily interact with gaseous HPFP solvent.…”

Analysis of Process Parameters Affecting Spray-Dried Oily Core Nanocapsules Using Factorial Design

“…Experimental results from other investigators also confirmed this theory. For instance, Tajber et al reported that the higher atomizing air flow was associated with smaller spray-dried microparticle (17), and this trend was also commonly observed (47,48). Mackaplow et al studied the effect of disk speed on rotary spray congealing of microspheres.…”

Polymeric Recrystallized Agglomerates of Cefuroxime Axetil Prepared by Emulsion Solvent Diffusion Technique

“…Spray-drying of a drug solution is another way to produce micron-sized spherical particles. Spray-dried drugs, which are amorphous, show a smaller and more homogeneous particle size than mechanically micronized drugs 7,8 . However, as a fine particle fraction, even spray-dried amorphous drugs show only incomplete dispersion 9 .…”