Production of the Same Antibiotics by Members of Different Genera of Microorganisms

Lechevalier, H. A.

doi:10.1016/s0065-2164(08)70421-0

Cited by 26 publications

(7 citation statements)

References 55 publications

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“…which showed activity against normal bacterial pathogens. It has long been known that some of the actinomycete strains of the same species could generate different antibiotics, where as some other strains belonging to different species generated the same antibiotics[15]. In this present study, the pigment producing actinomycete strain D10 ( Streptomyces hygroscopicus ) showed antibacterial activity against the drug resistant pathogens such as MRSA, VRSA and ESBL strains.…”

Section: Discussionmentioning

confidence: 56%

Antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening

Selvameenal¹,

Radhakrishnan²,

Balagurunathan

2009

Indian J Pharm Sci

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An actinomycete strain, Streptomyces hygroscopicus subsp. ossamyceticus (strain D10) was isolated from Thar Desert soil, Rajasthan during the year 2006 and found to produce a yellow color pigment with antibiotic activity. Crude pigment was produced from strain D10 by solid state fermentation using wheat bran medium followed by extraction with ethyl acetate. The antimicrobial activity of the crude pigment was evaluated against drug resistant pathogens such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Staphylococcus aureus, extended spectrum β-lactamase producing cultures of Escherichia coli, Pseudomonas aeruginosa and Klebsiella sp. About 420 mg of crude pigment was produced per 10 g of wheat bran medium. In the disc diffusion method the crude ethyl acetate extract showed a minimum of 10 mm inhibition against Klebsiella sp. and maximum of 19 mm of inhibition against Escherichia coli. The crude pigment was partially purified using thin layer chromatography with the solvent system chloroform:methanol (30:70) and the Rf value was calculated as 0.768. Antimicrobial activity of the partially purified compound from thin layer chromatography was determined using the bioautography method. The purified pigment showed minimum of 15 mm inhibition against Klebsiella sp. and a maximum of 23 mm of inhibition against vancomycin-resistant Staphylococcus aureus in the disc diffusion method. Based on the results of chemical screening, the pigment was tentatively identified as group of sugar containing molecules.

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Section: Discussionmentioning

confidence: 56%

Antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening

Selvameenal¹,

Radhakrishnan²,

Balagurunathan

2009

Indian J Pharm Sci

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“…Currently, 122 various secondary metabolites were isolated from mangrove actinomycetes; of these, 73 compounds were novel and remaining compounds were predicted previously (Xu et al 2014). It has long been known that some of the Streptomyces strains of the similar species might produce different antibiotics, whereas certain other strains belonging to different species produced the identical antibiotics (Lechevalier 1975). Therefore, the production of antibiotics by Streptomyces could not be species-specific, but slightly strain-specific.…”

Section: Resultsmentioning

confidence: 99%

Purification and structural elucidation of three bioactive compounds isolated from Streptomyces coelicoflavus BC 01 and their biological activity

et al. 2017

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The strain Streptomyces coelicoflavus BC 01 was isolated from mangrove soil and used as inoculum for submerged fermentation. The fermented broth was extracted with ethyl acetate, the crude extract was subjected to silica gel column chromatography and the homogeneity of the isolated fractions was determined by TLC and then subjected to RP-HPLC for their purity. The purification steps led to the isolation of three pure bioactive compounds named as BC 01_C1, BC 01_C2 and BC 01_C3. The chemical structure of these three compounds was established on the basis of their spectroscopic studies like UV, IR, 1H and 13C NMR and GC–MS data by comparison with reference data from literature. The structure of the compound BC 01_C1 was established as 5-amino-2-(6-(2-hydroxyethyl)-3-oxononyl) cyclohex-2-enone. The compound BC 01_C2 was established as8-(aminomethyl)-7-hydroxy-1-(1-hydroxy-4-(hydroxylmethoxy)-2,3-dimethylbutyl)-2-methyl dodecahydro phenanthren-9(1H)-one and the compound BC 01_C3 was established as1-((E)-2-ethylhex-1-en-1-yl)2-((E)-2-ethylidenehexyl)cyclohexane-1,2-dicarboxylate. The MIC values of the three isolated compounds (BC 01_C1, BC 01_C2 and BC 01_C3) were found between 12.5–75 μg/ml for bacteria and 50–125 μg/ml for fungi used in this study. These compounds also possess in vitro antioxidant and anti-inflammatory activities.

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“…Not in every case, however, does a certain type of natural product occur in related taxa. For example, cyanogenic glycosides have been found not only in insects but also in plants (Nahrstedt 1996), b-lactam antibiotics are produced by bacteria and fungi (Lechevalier 1975), taxol occurs in higher plants (Wani et al 1971;Walker and Croteau 2001), but is also present in microorganisms (Stierle et al 1995;Strobel et al 1996;Noh et al 1999;Caruso et al 2000;Wang et al 2000), while ergoline alkaloids are typical of fungi belonging to the family Clavicipitaceae and two unrelated plant families, viz. Convolvulaceae and Poaceae (Clay 1991;Gro¨ger and Floss 1998;Panaccione et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Elimination of ergoline alkaloids following treatment of Ipomoea asarifolia (Convolvulaceae) with fungicides

Kucht

Groß

Hussein

et al. 2004

Planta

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Ergoline alkaloids are constituents of Clavicipitaceous fungi living on Poaceae plants. Ergoline alkaloids as well as volatile oil are also present in Ipomoea asarifolia Roem. & Schult (Convolvulaceae). Treatment of this plant with two fungicides (Folicur, Pronto Plus) eliminates the ergoline alkaloids but not the volatile oil. Elimination of ergoline alkaloids occurs concomitantly with loss of fungal hyphae associated with secretory glands on the upper leaf surface of the Ipomoea plant. Our observations suggest that accumulation of ergoline alkaloids in the Convolvulaceae may depend on the presence of a plant-associated fungus.

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Production of the Same Antibiotics by Members of Different Genera of Microorganisms

Cited by 26 publications

References 55 publications

Antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening

Antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening

Purification and structural elucidation of three bioactive compounds isolated from Streptomyces coelicoflavus BC 01 and their biological activity

Elimination of ergoline alkaloids following treatment of Ipomoea asarifolia (Convolvulaceae) with fungicides

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