Production of the secondary metabolites γ-aminobutyric acid and monacolin K by Monascus

Su, Yi-Jen; Wang, Jyh‐Jye; Lin, Tzu-Tsen; Pan, Tzu‐Ming

doi:10.1007/s10295-002-0001-5

Cited by 222 publications

(194 citation statements)

References 22 publications

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“…Lovastatin production by SSF using Monscus. purpureus CCRC 31615 (19), M. purpureus NTU 601 (21), M. pilosus M12-69 (6), and M. ruber (22), are also reported in literature.…”

Section: Introductionmentioning

confidence: 87%

Response surface methodology for optimization of production of lovastatin by solid state fermentation

Pansuriya¹

2010

Braz. J. Microbiol.

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“…Lovastatin production by SSF using Monscus. purpureus CCRC 31615 (19), M. purpureus NTU 601 (21), M. pilosus M12-69 (6), and M. ruber (22), are also reported in literature.…”

Section: Introductionmentioning

confidence: 87%

Response surface methodology for optimization of production of lovastatin by solid state fermentation

Pansuriya¹

2010

Braz. J. Microbiol.

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“…(M. purpureus and M. ruber) has been employed in the preparation of Red-yeast rice (RYR), a traditional fermented food consumed in Asian countries as "red koji". Later, It was identified that lovastatin is a functional constituent of RYR [1,[13][14][15] . Monascus sp.…”

Section: Research Papermentioning

confidence: 99%

“…Monascus sp. was also exploited for various metabolites, viz., γ-aminobutyric acid, pigments, lipids, and structural analogues of lovastatin (pravastatin, compactin, monacolin J) [13,[16][17][18][19] . Endo [20] has first reported the production of lovastatin from Monascus sp.…”

Section: Research Papermentioning

confidence: 99%

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Cellular Localization and Production of Lovastatin from Monascus purpureus

Seenivasan¹,

Venkatesan²,

Tapobrata³

2018

pharmaceutical-sciences

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Seenivasan, et al.: Studies on Biosynthesis of LovastatinLovastatin is the first FDA-approved antihypercholesterolemic drug for the treatment of cardiovascular diseases. Monascus purpureus is one of the safest molds for the production of lovastatin that has been used in the preparation of Chinese medicine Red-yeast rice. This investigation dealt with the effect of both static and dynamic culture conditions on the morphological change and localization of lovastatin in Monascus purpureus. In dynamic culture condition, pellet morphology was observed and the maximum intra-and extra-cellular components of lovastatin including both β-hydroxy acid and lactone forms were 1043.45 and 207.94 μg/l, respectively. Filamentous (mat) form of morphology was observed in the static culture condition and the intra-and extracellular concentration of lovastatin were 677.9 and 789.2 μg/l, respectively. Taguchi's L 12 (11 2 ) orthogonal arrays was employed to find the optimal conditions for the submerged production of lovastatin and for the growth of Monascus purpureus. Three physical and five chemical variables were considered in the current experimental study. The maximum production of lovastatin was observed to be 3.66 mg/l. Among the chemical parameters, MnSO 4 and MgSO 4 were the most significant parameters for the production of lovastatin. Physical parameters, viz., agitation rate and temperature, were also equally significant for the production of lovastatin. Ammonium chloride was the most significant parameter among the variables studied for the growth of Monascus purpureus, followed by glucose and phosphorous sources (KH 2 PO 4 ). Statistical analysis showed that those parameters were significant with more than 99 % confidence (p<0.01).

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“…Therefore these four medium parameters were chosen for further optimization by response surface methodology (3,19,20). The various levels of nutrients are summarized in Table 4.…”

Section: Screening Of Nutrient Parametersmentioning

confidence: 99%

Production of angkak through co-culture of Monascus purpureus and Monascus ruber

Panda¹,

Javed²,

Ali³

2010

Braz. J. Microbiol.

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Angkak (red mold rice, red yeast rice, Chinese red rice) is a traditional Chinese medicine produced by solid-state fermentation of cooked non-glutinous rice with Monascus species. The secondary metabolite of Monascus species, monacolin K /lovastatin, has been proven to lower blood lipid levels. In this study, a coculture of Monascus purpureus MTCC 369 and Monascus ruber MTCC 1880 was used for angkak production. Four medium parameters screened by Plackett-Burman design were optimized by response surface methodology for highest lovastatin production in angkak during solid-state fermentation by the coculture. Maximum lovastatin production of 2.84 mg g -1 was predicted in solid medium containing 20 g rice and 40 ml liquid nutrients medium (malt extract 9.68 g l

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Production of the secondary metabolites γ-aminobutyric acid and monacolin K by Monascus

Cited by 222 publications

References 22 publications

Response surface methodology for optimization of production of lovastatin by solid state fermentation

Response surface methodology for optimization of production of lovastatin by solid state fermentation

Cellular Localization and Production of Lovastatin from Monascus purpureus

Production of angkak through co-culture of Monascus purpureus and Monascus ruber

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