Production of theophylline nanoparticles using rapid expansion of supercritical solutions with a solid cosolvent (RESS-SC) technique

Uchida, Hirohisa; Nishijima, Masamichi; Sano, Koki; Demoto, Kohei; Sakabe, Jun‐ichi; Shimoyama, Yusuke

doi:10.1016/j.supflu.2015.05.005

Cited by 27 publications

(20 citation statements)

References 42 publications

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“…The use of liquid [20] and solid [21] cosolvents to improve the solubility of the solute in supercritical fluid and modify the saturation rate has been associated to RESS process by numerous investigations.…”

Section: Rapid Expansion Of Supercritical Solution Processmentioning

confidence: 99%

“…Numerous investigations in particle formation with supercritical fluids have been carried out to shed light the parameter to govern the crystallization mechanism using CO 2 as antisolvent (SAS) [2][3][4][5][6][7][8][9][10][11][12][13][14][15] or as solvent (RESS) [16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

“…SAS technique has been investigated using solutes in a wide range of industrial fields with applications as polymers [30,31], explosives [32], pharmaceutical compounds [2,3], superconductors [33], catalysts [34], coloring matter [35], and functional food [6,7], among others. On the other hand, the application of RESS technique has been enclosed to pharmaceutical field [19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mean Aspects Controlling Supercritical CO₂ Precipitation Processes

Montes¹,

Pereyra²,

Ossa³

2019

Heat and Mass Transfer - Advances in Science and Technology Applications

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The use of supercritical CO 2 is an excellent alternative in extraction, particle precipitation, impregnation and reaction processes due to its special properties. Solubility of the compound in supercritical CO 2 drives the precipitation process in different ways. In supercritical antisolvent process, mass and heat transfers, phase equilibria, nucleation, and growth of the compound to be precipitated are the main phenomena that should be taken into account. Mass transfer conditions the morphology and particle size of the final product. This transfer could be tuned altering operating conditions. Heat transfer in non-isothermal process influences on mixing step the size of generated microparticles. In rapid expansion of supercritical solution, phenomena as the phase change from supercritical to a CO 2 gas flow, rapid mass transfer and crystallization of the compound, and expansion jet define the morphology and size of the final product. These phenomena a priori could be modulated tuning a large number of operating parameters through the experiments, but the correlations and modeling of these processes are necessary to clarify the relative importance of each one. Moreover, particle agglomeration in the expansion jet and CO 2 condensation are determinant phenomena which should be avoided in order to conserve fine particles in the final product.

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Section: Rapid Expansion Of Supercritical Solution Processmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mean Aspects Controlling Supercritical CO₂ Precipitation Processes

Montes¹,

Pereyra²,

Ossa³

2019

Heat and Mass Transfer - Advances in Science and Technology Applications

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“…Nanosized apigenin prepared by the SCF antisolvent process showed enhanced dissolution profiles at different pH values in comparison to parent particles [177]. Other examples include the use of SCF technology to enhance the dissolution rate of tetracycline [178], griseofulvin [127], ibuprofen [125], cyclosporine [179], paclitaxel [180] and theophylline [181] ( Tables 3 and 7). The SCF technology has been also used to engineer nanosized APIs with improved stability.…”

Section: Applicationsmentioning

confidence: 99%

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

Kaialy

Shafiee

2016

Advances in Colloid and Interface Science

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The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore pharmacokinetic properties similar to those observed in solutions. The present review outlines the recent advances, promises and challenges of the engineering nanosized APIs. The principles, merits, demerits and applications of the current 'bottom-up' and 'top-down' technologies by which the state of the art nanosized APIs can be produced were described. Although the number of research reports on the nanoparticle engineering topic has been growing in the last decade, the challenge is to take numerous research outcomes and convert them into strategies for the development of marketable products.

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“…RESS has been applied to the production of several thin films such as magnetic thin films (Dea et al, 2007), alkyl ketene dimer (AKD) layers (Quan et al, 2009), and polymer thin films (Lele and Shine, 1992;Shim et al, 1999;Chernyak et al, 2001;Levit et al, 2002;Fulton et al, 2003;Sarkar et al, 2006;Gallyamov et al, 2007;Pestov et al, 2007;Ratcharak and Sane, 2014). We have proposed a novel and simple production technique for organic thin films by RESS and have successfully produced thin films with large grains using organic materials including anthracene, pentacene, perfluoropentacene and rubrene on silicon substrates using RESS Uchida and Yamaguchi, 2008;Uchida et al, 2011;Fujii and Uchida, 2015). In the RESS technique, a solute is dissolved in a supercritical fluid, and the solution is then expanded rapidly through a nozzle.…”

Section: Introductionmentioning

confidence: 99%

Effects of Solution Concentrations on Crystal Growth of Anthracene Thin Films on Silicon by Rapid Expansion of Supercritical Solutions (RESS) Using Carbon Dioxide

Fujii

Takahashi

Uchida

2015

J. Chem. Eng. Japan / JCEJ

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We report on an investigation to the e ects of supercritical solution concentrations on the crystal morphology, crystallinity, growth rate, and number density of anthracene grains in thin lms on silicon substrates by rapid expansion of supercritical solutions (RESS) using carbon dioxide to examine the crystal growth mechanism of anthracene thin lms. (molar fraction; a threshold concentration) with a change in morphology of grains from dendritic to island-like. Although the number densities of island-like and dendritic grains increased almost linearly with the solution concentration, the trend in the number density of grains also changed at the threshold concentration, with the change in morphology from dendritic to island-like grains. The crystal growth of grains deposited on the substrate was dominant and most of the given supersaturation was consumed for the crystal growth of grains at solution concentrations lower than the threshold concentration. At solution concentrations higher than the threshold concentration, the crystal nucleation on the substrate was dominant and most of the given supersaturation was consumed for the crystal nucleation of grains, followed by the crystal growth of the grains.

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Production of theophylline nanoparticles using rapid expansion of supercritical solutions with a solid cosolvent (RESS-SC) technique

Cited by 27 publications

References 42 publications

Mean Aspects Controlling Supercritical CO₂ Precipitation Processes

Mean Aspects Controlling Supercritical CO₂ Precipitation Processes

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

Effects of Solution Concentrations on Crystal Growth of Anthracene Thin Films on Silicon by Rapid Expansion of Supercritical Solutions (RESS) Using Carbon Dioxide

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Production of theophylline nanoparticles using rapid expansion of supercritical solutions with a solid cosolvent (RESS-SC) technique

Cited by 27 publications

References 42 publications

Mean Aspects Controlling Supercritical CO2 Precipitation Processes

Mean Aspects Controlling Supercritical CO2 Precipitation Processes

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges

Effects of Solution Concentrations on Crystal Growth of Anthracene Thin Films on Silicon by Rapid Expansion of Supercritical Solutions (RESS) Using Carbon Dioxide

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Product

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Mean Aspects Controlling Supercritical CO₂ Precipitation Processes

Mean Aspects Controlling Supercritical CO₂ Precipitation Processes