Production of two species of interferon by Large White and Meishan pig conceptuses during the peri-attachment period

Bonnardière, Claude La; Martinat-Botté, F.; Terqui, M.; Lefèvre, François; Zouari, K.; Martal, J.; Bazer, Fuller W.

doi:10.1530/jrf.0.0910469

Cited by 100 publications

(54 citation statements)

References 25 publications

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“…By 1989, it had been confirmed that antiviral activity could be detected in pig uterine flushings and conceptus-conditioned culture medium between day 12 and 17 of gestation (Cross & Roberts 1989). It was determined later that pig conceptuses express the type II IFN, IFNγ, and a newly discovered type I IFN, IFNδ (Lefèvre et al 1990, La Bonnardière et al 1991.…”

Section: Ifnγ/ifnδ and Reproductionmentioning

confidence: 99%

“…The pig is unique in that the IL1B gene is duplicated, resulting in a novel gene and conceptus form of IL1β (interleukin-1 beta 2; IL1β2) (Vandenbroeck et al 1993, Groenen et al 2012, Mathew et al 2015. Conceptus expression of IL1β2 is followed by abundant production of interferon gamma (IFNγ) by pig conceptuses and, in lesser concentrations, a pregnancy-specific type I IFN, interferon delta (IFNδ) (La Bonnardière et al 1991). These cytokines are expressed during the synthesis of conceptus estrogens for maternal recognition of pregnancy (Bazer & Thatcher 1977).…”

Section: Introductionmentioning

confidence: 99%

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Interleukins, interferons, and establishment of pregnancy in pigs

Mathew¹,

Lucy²,

Geisert³

2016

Reproduction

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Early pregnancy in mammals requires complex and highly orchestrated cellular and molecular interactions between specialized cells within the endometrium and the conceptus. Proinflammatory cytokines are small signaling proteins released by leukocytes that augment innate and adaptive immune responses. They are also released by the mammalian trophectoderm as the conceptus apposes the uterine surface for implantation. On approximately day 12 of development in pigs, the conceptus undergoes a rapid morphological transformation referred to as elongation while simultaneously releasing estrogens and a novel conceptus form of interleukin-1 beta (IL1β). Following elongation, pig conceptuses express interferon gamma (IFNγ) and, in lesser amounts, interferon delta (IFNδ). Significant IFN signaling takes place within the endometrium between day 14 and 18 of pregnancy as the conceptus intimately associates with the uterine epithelium. Based on studies carried out in pigs and other mammals, the combined spacio-temporal activities of conceptus estrogens, IL1β, and IFN set in motion a series of coordinated events that promote establishment of pregnancy. This is achieved through enhancement of conceptus development, uterine receptivity, maternal-fetal hemotropic exchange, and endometrial leukocyte function. These events require activation of specific signaling pathways within the uterine luminal epithelium, glandular epithelium, and stroma. Here, we review proinflammatory cytokine expression by pig conceptuses and the hypothesized actions of these molecules during establishment of pregnancy.Reproduction (2016) 151 R111-R122

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Section: Ifnγ/ifnδ and Reproductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interleukins, interferons, and establishment of pregnancy in pigs

Mathew¹,

Lucy²,

Geisert³

2016

Reproduction

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“…In pigs, two IFN species, clearly different from IFN-τ , were found to be developmentally induced and secreted by implanting embryos [45,49]. A weak secretion of IFN-γ was detected in in vitro developing human embryos, just before implantation [61].…”

Section: Embryonic Interferons In Mammalsmentioning

confidence: 99%

“…Further analysis has revealed that two species are present in the uterine flushings and in the supernatants of conceptus-conditioned media between days 12-20 of gestation. The predominant species was found to be an IFN-γ [45,49]. The other species was shown to be a novel type I interferon, IFN-δ, previously known as sp-1 [48].…”

Section: Embryonic Ifns In Pigsmentioning

confidence: 99%

“…In spite of the known facts that several factors, like hormones, growth factors and cytokines regulate maternal recognition of pregnancy, it was unexpectedly found that just before implantation, the pig trophoblast secretes large amounts of interferon gamma (IFN-γ ) and a novel interferon delta (IFN-δ) [45,48,49]. Production of these embryonic interferons by the trophoblast, particularly IFN-γ , is a unique case, as is its source of secretion and the fact it being developmentally induced.…”

Section: Introductionmentioning

confidence: 99%

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Trophoblastic interferon-gamma: current knowledge and possible role(s) in early pig pregnancy

Cencič

Bonnardière

2002

Vet. Res.

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-In the pig as in ruminant species, the implantation of the elongated conceptus -the embryo with its associated membranes -onto the maternal uterus is accompanied by an intense secretion of interferon (IFN), which culminates at day 15 of development. It has been shown that in fact the pig trophectoderm -the polarized epithelium which lines the conceptus -simultaneously secretes two types of interferons: IFN-gamma (IFN-γ ), which is the more abundant species, is produced in very substantial amounts. Another IFN is also secreted, which happens to be a novel type I IFN, now named IFN-δ. It was previously shown that the uterus is the most probable target of the pig trophoblastic IFNs, since no autocrine effect was found on the trophoblast. It has also been shown that, unlike for the ruminant species, the pig trophoblastic IFNs do not play an apparent role in the so-called maternal recognition of pregnancy. We have focused this review on IFN-γ , because first, it is the major species secreted and secondly, IFN-γ has various regulatory effects on different tissues, including lymphoid cells. We particularly address the question of the possible role of trophoblastic IFN-γ in early pregnancy, in the light of the known biological functions of human and mouse IFN-γ .interferon-gamma / embryo / trophoblast / pig / implantation Résumé -Interféron-gamma trophoblastique : état actuel des connaissances et rôle(s) possible(s) en début de gestation chez le porc. Chez le porc, comme chez les ruminants, l'implantation du conceptus (l'embryon et ses membranes annexes) dans l'utérus maternel s'accompagne d'une intense sécrétion d'interféron (IFN), laquelle culmine au 15 e jour du développement. On a montré que le trophectoderme -l'épithélium polarisé qui borde le conceptus -sécrète simultanément deux types d'IFN : l'IFN-gamma, qui est le plus abondant, est produit en très grande quantité. L'autre interféron, apparenté aux IFN de type I, s'avère être une nouvelle espèce, nommée IFN-δ. Des résultats antérieurs ont montré que l'utérus est la cible la plus probable des interférons trophoblastiques, puisqu'aucun effet autocrine 139 Vet. Res. 33 (2002) 139-157

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Cytokines in mammalian reproduction and speculation about their possible involvement in nonmammalian viviparity

Paulesu

1997

Microsc. Res. Tech.

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Production of two species of interferon by Large White and Meishan pig conceptuses during the peri-attachment period

Abstract: Summary. Antiviral

Cited by 100 publications

References 25 publications

Interleukins, interferons, and establishment of pregnancy in pigs

Interleukins, interferons, and establishment of pregnancy in pigs

Trophoblastic interferon-gamma: current knowledge and possible role(s) in early pig pregnancy

Cytokines in mammalian reproduction and speculation about their possible involvement in nonmammalian viviparity

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