Production of Volatile Nitrogenous Compounds from the Degradation of Streptomycin by
            <i>Pseudomonas maltophilia</i>

Fenton, John; Harsch, Harold H.; Klein, Dolph

doi:10.1128/jb.116.3.1267-1272.1973

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…If drying is incomplete, the equipment may become contaminated with S. maltophilia, particularly since the organism is known to adhere to plastics (19). It is not known if S. maltophilia would be capable of surviving exposure to the extremely high concentrations of tobramycin that occur in this setting, but it is interesting to note that a strain of S. maltophilia has been reported that utilized streptomycin as an energy source (13). Further studies would be needed to assess the level of contamination of nebulizers with S. maltophilia.…”

Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Stenotrophomonas maltophilia Isolated from Clinical Specimens from Patients with Cystic Fibrosis and Associated Environmental Samples

Todd²,

et al. 1998

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Stenotrophomonas maltophilia was isolated from the respiratory tracts of 41 (25%) of 163 children attending our pediatric cystic fibrosis unit between September 1993 and December 1995. The extents of S. maltophilia contamination of environmental sites frequented by these patients were investigated with a selective medium incorporating vancomycin, imipenem, and amphotericin B. Eighty-two isolates of S. maltophilia were cultured from 67 different environmental sites sampled between January and July 1996. The organism was widespread in the home environment, with 20 (36%) and 25 (42%) of sampled sites positive in the homes of colonized and noncolonized patients, respectively. In the nosocomial setting, it was isolated from 18 (32%) sites in the hospital ward and from 4 (17%) sites in the outpatient clinic area. The most common sites of contamination were sink drains, faucets, and other items frequently in contact with water. All environmental and clinical isolates were genotyped with enterobacterial repetitive intergenic consensus sequences as primers. A total of 33 of the 41 patients were colonized with unique strains, and four pairs of patients shared strains. Further characterization by pulsed-field gel electrophoresis after digestion with XbaI found that there was no evidence of patient-to-patient transmission; however, there was some evidence that a small number of patients may have acquired the organism from the hospital environment. Resampling of environmental sites in the hospital ward in January 1997 revealed evidence of genetic drift, complicating the accurate determination of environmental sources for clinical strains. The source of the majority of S. maltophiliastrains colonizing the respiratory tracts of these patients with cystic fibrosis remained uncertain but may have represented multiple, independent acquisitions from a variety of environmental sites both within and outside the hospital.

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Section: Discussionmentioning

confidence: 99%

Molecular Epidemiology of Stenotrophomonas maltophilia Isolated from Clinical Specimens from Patients with Cystic Fibrosis and Associated Environmental Samples

Todd²,

et al. 1998

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“…The bacterium has been regarded as relatively metabolically inactive (395), but a variety of unusual substrates, including the aminoglycoside antibiotic streptomycin (127), may be metabolized (37,39,55,191,209,244,273,291,333,398) and strains of the bacterium have been investigated for their potential use as biodegradative agents. Selected biochemical characteristics and microbiological reactions of S. maltophilia are shown in Table 1.…”

Section: Biochemical Characteristicsmentioning

confidence: 99%

“…It has been isolated from a number of water sources including rivers, wells, a hypereutrophic lake, and bottled water (in which it may be responsible for altered organoleptic properties), and sewage (13,167,176,183,184,185,219,288,319). The bacterium has also been recovered from a variety of soil (44,85,127,400) and plant rhizosphere environments, including grasses, sugarcane and palms (202), from wheat (203), cabbage, rape, mustard, corn (86), beet (86,243), bananas, cotton, beans, tobacco (183), rice paddies (235), citrus plants (1), orchids (447), irises (25), legume inoculants which use nonsterile peat as a carrier (306), and stored timber (108). Iizuka and Komagata reported the isolation of S. maltophilia from oil brines and other related materials from oil fields in Japan (191).…”

Section: Geneticsmentioning

confidence: 99%

Microbiological and Clinical Aspects of Infection Associated with Stenotrophomonas maltophilia

1998

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SUMMARY The gram-negative bacterium Stenotrophomonas maltophilia is increasingly recognized as an important cause of nosocomial infection. Infection occurs principally, but not exclusively, in debilitated and immunosuppressed individuals. Management of S. maltophilia-associated infection is problematic because many strains of the bacterium manifest resistance to multiple antibiotics. These difficulties are compounded by methodological problems in in vitro susceptibility testing for which there are, as yet, no formal guidelines. Despite its acknowledged importance as a nosocomial pathogen, little is known of the epidemiology of S. maltophilia, and although it is considered an environmental bacterium, its sources and reservoirs are often not readily apparent. Molecular typing systems may contribute to our knowledge of the epidemiology of S. maltophilia infection, thus allowing the development of strategies to interrupt the transmission of the bacterium in the hospital setting. Even less is known of pathogenic mechanisms and putative virulence factors involved in the natural history of S. maltophilia infection and this, coupled with difficulties in distinguishing colonization from true infection, has fostered the view that the bacterium is essentially nonpathogenic. This article aims to review the current taxonomic status of S. maltophilia, and it discusses the laboratory identification of the bacterium. The epidemiology of the organism is considered with particular reference to nosocomial outbreaks, several of which have been investigated by molecular typing techniques. Risk factors for acquisition of the bacterium are also reviewed, and the ever-expanding spectrum of clinical syndromes associated with S. maltophilia is surveyed. Antimicrobial resistance mechanisms, pitfalls in in vitro susceptibility testing, and therapy of S. maltophilia infections are also discussed.

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“…Previous studies showed that the phytotoxicity of antibiotics on plants in the soil varies between plant species and antibiotic compounds, and antibiotics could have a biphasic effect on plant growth characterized by low-dose stimulation and high-dose inhibition, which is also called hormesis. − Thus, oxytetracycline might also induce hormesis in radish plants, but streptomycin did not. In this study, although the continuous soil drenching was conducted for 74 days, the low bioavailabilities of both antibiotics in soil due to the strong adsorption on soil components and rapid degradations − might be the reason for no inhibition effect on plant growth.…”

Section: Resultsmentioning

confidence: 98%

Uptake of the Plant Agriculture-Used Antibiotics Oxytetracycline and Streptomycin by Cherry Radish─Effect on Plant Microbiome and the Potential Health Risk

Yin

Wang

et al. 2023

J. Agric. Food Chem.

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Antibiotics are used to control certain bacterial diseases in plant agriculture. Understanding antibiotic uptake by edible vegetables after application and associated risks on plant microbiome and human health is critical. In this study, oxytetracycline and streptomycin, the two most commonly used antibiotics in plant agriculture, were applied to cherry radish via continuous soil drenching to study their translocations into plant tissues, influence on radish microbiome, and the potential health risk to mice. The results demonstrated that oxytetracycline induced hormesis in radish plants and both antibiotics were translocated into the leaves, fruits, and roots of radishes from the soil, with significantly higher plant uptake of streptomycin than oxytetracycline. Interestingly, the proportion of culturable oxytetracycline or streptomycin-resistant bacteria in the antibiotic-accumulated radish tissues was significantly higher than that in the antibiotic-free radish tissues, although both bacterial and fungal communities in different radish tissues were not affected by the accumulated antibiotics, demonstrating that antibiotic application could enrich antibiotic resistance in the plant microbiome. Feeding mice with antibiotics-accumulated radish tissues did not show significant effects on the weight and blood glucose levels of mice. Overall, this study provides important insights into the risk of using antibiotics in plant agriculture.

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Production of Volatile Nitrogenous Compounds from the Degradation of Streptomycin by Pseudomonas maltophilia

Cited by 11 publications

References 17 publications

Molecular Epidemiology of Stenotrophomonas maltophilia Isolated from Clinical Specimens from Patients with Cystic Fibrosis and Associated Environmental Samples

Molecular Epidemiology of Stenotrophomonas maltophilia Isolated from Clinical Specimens from Patients with Cystic Fibrosis and Associated Environmental Samples

Microbiological and Clinical Aspects of Infection Associated with Stenotrophomonas maltophilia

Uptake of the Plant Agriculture-Used Antibiotics Oxytetracycline and Streptomycin by Cherry Radish─Effect on Plant Microbiome and the Potential Health Risk

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