Production of xanthan gum using immobilized Xanthomonas campestris cells: Effects of support type

Nejadmansouri, Maryam; Shad, Ehsan; Razmjooei, Maryam; Safdarianghomsheh, Reza; Delvigne, Frank; Khalesi, Mohammadreza

doi:10.1016/j.bej.2020.107554

Cited by 34 publications

(12 citation statements)

References 64 publications

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“…First, we carried out a structural characterization by FT-IR to determine functional groups (Figure 1). In concordance with previous reports, we observed several characteristic bands corresponding to XG and PVP (30,31). However, during the determination of the spectrum corresponding to XG+PVP, we found signals at similar values to the PVP spectrum.…”

Section: Discussionsupporting

confidence: 92%

Physicochemical and biological characterization of a xanthan gum-polyvinylpyrrolidone hydrogel obtained by gamma irradiation

López-Huante

Prado-Audelo

Caballero-Florán

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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Xanthan gum (XG) and polyvinylpyrrolidone (PVP) are two polymers with low toxicity, high biocompatibility, biodegradability, and high hydrophilicity, making them promising candidates for multiple medical aspects. The present work aimed to synthesize a hydrogel from a mixture of XG and PVP and crosslinked by gamma irradiation. We assessed the hydrogel through a series of physicochemical (FT-IR, TGA, SEM, and percentage of swelling) and biological (stability of the hydrogel in cell culture medium) methods that allowed to determine its applicability. The structural evaluation by infrared spectrum demonstrated that a crosslinked hydrogel was obtained from the combination of polymers. The calorimetric test and swelling percentage confirmed the formation of the bonds responsible for the crosslinked structure. The calorimetric test evidenced that the hydrogel was resistant to decomposition in contrast to non-irradiated material.The determination of the swelling degree showed constant behavior over time, indicating a structure resistant to hydrolysis. This phenomenon also occurred during the test of stability in a cell culture medium. Additionally, microscopic analysis of the sample revealed an amorphous matrix with the presence of porosity. Thus, the findings reveal the synthesis of a novel material that has desirable attributes for its potential application in pharmaceutical and biomedical areas.

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Section: Discussionsupporting

confidence: 92%

Physicochemical and biological characterization of a xanthan gum-polyvinylpyrrolidone hydrogel obtained by gamma irradiation

López-Huante

Prado-Audelo

Caballero-Florán

et al. 2021

Cell Mol Biol (Noisy-le-grand)

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“…Peak at 1. unit C, which is known as the more deshielded proton is located at 5.2 ppm [24]. These findings are in agreement with NMR spectra recorded for xanthan [25][26][27][28]. The evidence that the acrylic acid esterification reaction took place is given by the NMR spectrum of the modified xanthan in Figure 3b.…”

Section: Nmr Characterizationsupporting

confidence: 87%

Xanthan Matrix as Drug ZDelivery System

Anghel¹,

Dinu²,

Doroftei³

et al. 2021

Rev. Chim.

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Here we present a new drug delivery system based on xanthan esterified with acrylic acid. This material served as a matrix for the incorporation of bioactive substances with antimicrobial and anti-inflammatory properties. The materials were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) and Scanning Electron Micrography (SEM). Mechanical strength tests showed a substantial improvement in the resilience and flexibility of the polymer matrix modified by esterification under conditions of mechanical stress. The release of bioactive substances from the basic matrix follows a Korsmeyer-Peppas type kinetics. The modified xanthan-based transport system was shown to be antimicrobially active with an inhibition rate of almost 100% on gram-positive and gram-negative bacteria. The obtained results recommend this biomaterial for the manufacture of transdermal drug delivery devices.

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“…The endothermal lower and exothermal higher temperatures have been established as moisture loss and thermal decomposition, respectively. 41 …”

Section: Resultsmentioning

confidence: 99%

“…The endothermal lower and exothermal higher temperatures have been established as moisture loss and thermal decomposition, respectively. 41 the other side, PVA presented an endothermic peak at 213.5 C (solid arrows); meanwhile, the physical mixture exhibited two thermal events at 178.3 C and 223.4 C, which are associated with the thermal events of the pristine XG and PVA. These events occur in lower intensity coupled with the proportions at which the polymers were mixed, and the thermal event at 178.3 C is slightly more intense.…”

Section: Thermal Propertiesmentioning

confidence: 99%

Cross-linked polyvinyl alcohol-xanthan gum hydrogel fabricated by freeze/thaw technique for potential application in soft tissue engineering

et al. 2022

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Production of xanthan gum using immobilized Xanthomonas campestris cells: Effects of support type

Cited by 34 publications

References 64 publications

Physicochemical and biological characterization of a xanthan gum-polyvinylpyrrolidone hydrogel obtained by gamma irradiation

Physicochemical and biological characterization of a xanthan gum-polyvinylpyrrolidone hydrogel obtained by gamma irradiation

Xanthan Matrix as Drug ZDelivery System

Cross-linked polyvinyl alcohol-xanthan gum hydrogel fabricated by freeze/thaw technique for potential application in soft tissue engineering

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