Intelligent wells can improve oil recovery, mitigate risks and avoid unnecessary well intervention in petroleum fields. However, there is no consolidated methodology to evaluate the applicability of intelligent wells and to represent them in commercial simulators, which complicates the comparison with conventional wells. Moreover, there are two main modes of operation of intelligent well valves, reactive and proactive; each one can provide different benefits. In general, proactive control seeks maximum oil recovery, but it requires larger computational effort and greater knowledge of the reservoir than the reactive control. This paper presents a comparison between different configurations of intelligent wells with proactive control and mode operation on/off: (1) five-spot configuration with conventional wells (producer and injectors), (2) one intelligent producer and four conventional injectors, (3) one conventional producer and four intelligent injectors and (4) one intelligent producer and four intelligent injectors, in order to compare the different behaviors. The objective of this study is to evaluate the potential of proactive operation for each type of configuration and the benefits of the intelligent injectors and producer acting separately or together, considering the effects on production and costs of intelligent completion. For this, a genetic algorithm was coupled to a commercial simulator to optimize the proactive control and to search the maximum net present value (NPV), determining the optimum operation control for each valve. The case study consists of one heterogeneous reservoir model, light oil and three economic scenarios (pessimistic, probable and optimistic). Results show that the use of intelligent injector and producer wells together, in this case study, can increase of oil production and decrease of water production, although it may not be the most advantageous alternative because of the higher investment. On the other hand, the configuration using only an intelligent producer well (lower investment) is capable of increasing oil recovery sufficiently, therefore making the best investment with intelligent completion, in this case study.