Production study of high specific activity NCA Re-186g by proton and deuteron cyclotron irradiation

Bonardi, M.; Groppi, F.; Manenti, S.; Persico, E.; Gini, L.; Abbas, K.; Holzwarth, Uwe; Simonelli, Federica; Alfassi, Zeev B.

doi:10.1007/s10967-009-0380-4

Cited by 11 publications

(11 citation statements)

References 29 publications

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“…The stack of thin foils consisted of alternating aluminum (as both catcher and energy degrader foils), natural W and -depending on the irradiation -one or two Ti beam monitor foils to verify the reliability of charge integration system [19,20].…”

Section: Experimental Technique and Data Analysismentioning

confidence: 99%

“…Other errors affecting the total uncertainty are the uncertainty in the average incident energy of the original beam. For the foils other than the first one this is due mainly to the straggling phenomenon, that was evaluated with the SRIM-2010 code and a ±0.2 energy uncertainty on the nominal incident beam energy [19,21].…”

Section: Experimental Technique and Data Analysismentioning

confidence: 99%

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Excitation functions and yields for cyclotron production of radiorheniumvia^natW(p,ߙxn)^181-186gRe nuclear reactions and tests on the production of^186gRe using enriched¹⁸⁶W

Bonardi¹,

Groppi

Persico

et al. 2010

Radiochimica Acta

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Excitation functions and thin-target yields for the 181−186g Re radionuclides have been measured by the stacked-foil activation technique on tungsten foils of natural isotopic composition for different proton energies up to 22.0 MeV. A further check on the cross sections was done by irradiation of thick-targets and comparing the irradiated thicktarget yields with those calculated by analytical integration from the thin-target yields. The production of 186g Re was also studied by the irradiation of thick-target of enriched 186 W with a 13.6 ± 0.2 MeV proton beam. The results for 186 W( p, n) 186g Re were compared also to those calculated by the EMPIRE II code (version 2.19), due to 186g Re extensive applications in nuclear medicine for metabolic radiotherapy of tumours. It was found that the maximum percentage of 186g Re by irradiation of natural tungsten is about 20% only, which confirms the conclusion that high radionuclidic purity and specific activity of 186g Re necessitate the use of highly enriched 186 W target.

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Section: Experimental Technique and Data Analysismentioning

confidence: 99%

Section: Experimental Technique and Data Analysismentioning

confidence: 99%

Excitation functions and yields for cyclotron production of radiorheniumvia^natW(p,ߙxn)^181-186gRe nuclear reactions and tests on the production of^186gRe using enriched¹⁸⁶W

Bonardi¹,

Groppi

Persico

et al. 2010

Radiochimica Acta

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“…Based on nuclear model calculations the specific activity of 186 Re was also predicted [60]. More recent experimental work in this direction [61,62] appears to support the theoretical considerations. Presently, some practical yield measurements [cf.…”

Section: Rementioning

confidence: 61%

Nuclear data for medical radionuclides

Qaim

2015

J Radioanal Nucl Chem

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Radionuclides are used in medicine both for diagnosis and therapy. The radioactive decay data play a key role in the choice of a radionuclide for a certain application. The nuclear reaction data, on the other hand, allow to optimise the production route of a chosen radionuclide. The status of nuclear data of the commonly used diagnostic and therapeutic radionuclides is reviewed and the recent efforts to standardise those data are described. The expected specific activity of the cyclotron produced 99m Tc is briefly discussed. The present efforts are devoted to development of non-standard positron emitters (e.g. 64 Cu, 86 Y, etc.) and low-range highly-ionising therapeutic radionuclides (e.g. 67 Cu, 225 Ac, etc.). The need of intermediate-energy multiple-particle accelerating cyclotrons is pointed out.

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“…Cross sections for the nat W(p,x) 186 Re reaction have been reported in the literature (Bonardi 2010, Lapi 2007, Tárkányi 2007, Shigeta 1996. There is some discrepancy on the absolute value of the cross section but there is agreement that the optimal cross section is observed at ~10 MeV.…”

Section: Ws 2 Target Irradiationsmentioning

confidence: 90%

“…Production in an accelerator, such as the PETtrace at the University of Missouri Research Reactor Center (MURR), can theoretically provide a specific activity of 34,600 Ci/mmol -1 Re, which represents a 62-fold increase over reactorproduced 186 Re. Previous studies on accelerator-based production of 186 Re primarily used tungsten targets (Moustapha 2006, Bonardi 2010, Lapi 2007, Fassbender 2013, Tárkányi 2007, Shigeta 1996, Tárkányi 2003, while osmium target studies are limited (Szelecsényi 2009). The use of osmium targets to produce platinum and iridium radioisotopes has been reported (Hilgers 2005, Hilgers 2009, Hermanne 2015, Szelecsényi 2010), using either a thin electrodeposited layer of the metal or a thin metal foil.…”

Section: Introductionmentioning

confidence: 99%

Accelerator-based production of the 99mTc-186Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2)

Gott

Hayes

Wycoff

et al. 2016

Applied Radiation and Isotopes

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Novel, natural abundance metal disulfide targets were irradiated for 1h with a 10µA proton beam in a small, medical cyclotron. Osmium disulfide was synthesized by simple distillation and precipitation methods while MoS2 and WS2 were commercially available. The targets dissolved under mild conditions and were analyzed by γ-spectroscopy. Production rates and potential applications are discussed, including target recovery and recycling schemes for OsS2 and WS2.

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Production study of high specific activity NCA Re-186g by proton and deuteron cyclotron irradiation

Cited by 11 publications

References 29 publications

Excitation functions and yields for cyclotron production of radiorheniumvia^natW(p,ߙxn)^181-186gRe nuclear reactions and tests on the production of^186gRe using enriched¹⁸⁶W

Excitation functions and yields for cyclotron production of radiorheniumvia^natW(p,ߙxn)^181-186gRe nuclear reactions and tests on the production of^186gRe using enriched¹⁸⁶W

Nuclear data for medical radionuclides

Accelerator-based production of the 99mTc-186Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2)

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Production study of high specific activity NCA Re-186g by proton and deuteron cyclotron irradiation

Cited by 11 publications

References 29 publications

Excitation functions and yields for cyclotron production of radiorheniumvianatW(p,ߙxn)181-186gRe nuclear reactions and tests on the production of186gRe using enriched186W

Excitation functions and yields for cyclotron production of radiorheniumvianatW(p,ߙxn)181-186gRe nuclear reactions and tests on the production of186gRe using enriched186W

Nuclear data for medical radionuclides

Accelerator-based production of the 99mTc-186Re diagnostic-therapeutic pair using metal disulfide targets (MoS2, WS2, OsS2)

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Excitation functions and yields for cyclotron production of radiorheniumvia^natW(p,ߙxn)^181-186gRe nuclear reactions and tests on the production of^186gRe using enriched¹⁸⁶W

Excitation functions and yields for cyclotron production of radiorheniumvia^natW(p,ߙxn)^181-186gRe nuclear reactions and tests on the production of^186gRe using enriched¹⁸⁶W