2019
DOI: 10.1089/aivt.2017.0033
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Profibrotic Activity of Multiwalled Carbon Nanotubes Upon Prolonged Exposures in Different Human Lung Cell Types

Abstract: Introduction: The expanding use of multiwalled carbon nanotubes (MWCNTs) in various consumer and industrial products has raised concerns regarding the potential health risks following the inhalation of this nanomaterial. Recent studies indicate that MWCNT exposure can cause deleterious lung effects. Pulmonary fibrosis is one of the diseases associated with the inhalation of classical fiber-shaped materials (e.g., asbestos), and recently MWCNTs. Materials and Methods: Herein, the presented work investigated ear… Show more

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Cited by 27 publications
(26 citation statements)
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“…Two types of MWCNTs, namely, Mitsui-7 CNTs (or simply Mitsui-7) and Nanocyl-7000 CNTs (or simply Nanocyl) were used, since they possess different physico-chemical characteristics [13].…”
Section: Characterization Of Cntsmentioning
confidence: 99%
See 1 more Smart Citation
“…Two types of MWCNTs, namely, Mitsui-7 CNTs (or simply Mitsui-7) and Nanocyl-7000 CNTs (or simply Nanocyl) were used, since they possess different physico-chemical characteristics [13].…”
Section: Characterization Of Cntsmentioning
confidence: 99%
“…Alveolar epithelial cells are one of the first target cells when CNTs are inhaled [20] and previous in vitro and in vivo data have demonstrated that CNTs inside the lungs are not only incorporated into alveolar macrophages [21,22] but also by epithelial cells, including type I [23] and type II epithelial cells [13,[24][25][26][27]. In addition, A549 exposure to CNTs such as Mitsui-7 and Nanocyl at concentrations of up to 20 µg/mL did not result in any cytotoxic response [13]. Briefly, A549 were cultured in the presence of both CNTs at concentrations of 10 and 20 µg/mL for 48 h. Next, the cells were washed three times with PBS to remove non-interacting CNTs.…”
Section: Interaction Of Cnts With Cellsmentioning
confidence: 99%
“…The first three cell types form confluent epithelial and mesothelial cell monolayers, allowing for measurements to determine the produced heat per surface area of a single cellular layer. J774A.1 was included due to the a The dimensions of the CNTs were taken from Chortarea et al and Poulsen et al 31,32 fact that they are professional-phagocytic cells that efficiently take up diverse NPs. As these cells do not form confluent monolayers, a heat signal which was not evenly distributed was expected.…”
Section: Resultsmentioning
confidence: 99%
“…50,51 Lower exposure concentrations for CNTs in comparison to AuNPs were applied, as a significant increase in cytotoxicity for increasing CNT concentration has been reported. 31 Samples were measured using LIT centred at a wavelength of 400 nm to excite the MWCNTs due to their increasing light absorbance in the lower wavelength range (Fig. S1 †).…”
Section: Cell Associated Cntsmentioning
confidence: 99%
“…The greatest exposure route for ENMs is through inhalation, leading to concern that ENMs will cause or exacerbate respiratory diseases. Many previous studies have shown that ENMs cause chronic lung inflammation, pulmonary fibrosis, lung cancer, or exacerbation of allergic lung disease in experimental animals [ 56 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ]. Other studies using cultured human or rodent lung cells demonstrate that ENMs increase the production of pro-inflammatory or pro-fibrotic mediators [ 76 , 77 ].…”
Section: Introductionmentioning
confidence: 99%