Proficiencies of Zingiber officinale against spine curve and vertebral damage induced by corticosteroid therapy associated with gonadal hormone deficiency in a rat model of osteoporosis

Zammel, Nourhene; Amri, Nahed; Chaabane, Rim; Rebaï, Tarek; Badraoui, Riadh

doi:10.1016/j.biopha.2018.04.159

Cited by 9 publications

(5 citation statements)

References 49 publications

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“…Knowing that garlic extract is an unstable compound, it is possible that ginger and garlic extracts have interacted with one another, causing the ∼30% decrease. Nevertheless, ginger extract shows an improvement in cellular viability which is corroborated by another work reporting enhanced bone formation and a reduction in bone loss with vertebral microarchitecture . Reduced osteoclast resorption pits and reduced overall osteoclast activity are also found in this work utilizing ginger extract as well as garlic extract.…”

Section: Discussionsupporting

confidence: 87%

“…Nevertheless, ginger extract shows an improvement in cellular viability which is corroborated by another work reporting enhanced bone formation and a reduction in bone loss with vertebral microarchitecture. 42 Reduced osteoclast resorption pits and reduced overall osteoclast activity are also found in this work utilizing ginger extract as well as garlic extract. The employment of ginger extract has various explanations for the attrition in osteoclastogenesis including influencing the inflammatory response NF-κβ pathway, suppressing the interleukin (IL)-1-induced prostaglandin E 2 (PGE 2 ) production in osteoblasts, or affecting the RANK ligand expression in osteoblast cells.…”

Section: ■ Discussionsupporting

confidence: 74%

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Ginger and Garlic Extracts Enhance Osteogenesis in 3D Printed Calcium Phosphate Bone Scaffolds with Bimodal Pore Distribution

Bose

Banerjee

2022

ACS Appl. Mater. Interfaces

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Natural medicines have long been used to treat physiological ailments where both ginger (gingerol) and garlic (allicin) are key players in immune system promotion, reduction in blood pressure, and lowering inflammation response. With their efficacy in bone healing, these compounds have great value as medicinal additives in bone scaffolds for localized treatment to support tissue formation, along with providing their natural therapeutic benefits. Utilization of 3D-printed (3DP) bone tissue engineering scaffolds as drug delivery vehicles for ginger and garlic extracts enables patient specificity in bone defect applications with enhanced osseointegration. Our objective is to understand their combined efficacy on osteogenesis when released from 3DP calcium phosphate bone scaffolds designed with a bimodal pore distribution. With a porous core and dense exterior, the resulting scaffolds have good mechanical integrity with 10 ± 1 MPa compressive strengths. Results show that ginger + garlic extracts released from bone scaffolds enhance their osteogenic potential through on site drug delivery. Both compounds exhibit exponential drug release profiles which fit Weibull distribution equations. The release of ginger extract also increases osteoblast proliferation by 59%. Both compounds show decreased osteoclast resorption activity, with a greater than 20% reduction in pit area on sample surfaces. Ginger + garlic extract induces a twofold increase in early osteoid tissue formation in vivo at week 4, in addition to a 30% increase in total bone area and a 90% increase in osteocytes with respect to control 3DP tricalcium phosphate scaffolds. Late-stage bone healing at week 10 reveals healthy angiogenic tissue, a twofold higher bone mineralization, and significant enhancement of type I collagen formation in the presence of ginger and garlic extracts. Naturally sourced ginger and garlic extracts provide osteogenic promotion and improved bone tissue in-growth in a patient-specific 3DP scaffold biomedical device for low load-bearing bone tissue engineering and dental applications.

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Section: Discussionsupporting

confidence: 87%

Section: ■ Discussionsupporting

confidence: 74%

Ginger and Garlic Extracts Enhance Osteogenesis in 3D Printed Calcium Phosphate Bone Scaffolds with Bimodal Pore Distribution

Bose

Banerjee

2022

ACS Appl. Mater. Interfaces

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“…It can be concluded that the negative effects of diabetes on the mechanical properties of the bone were prevented by using ginger in diabetic rats. In addition, Zammel et al (2018) also reported that ginger showed a potential protective effect by reducing changes in vertebral microarchitecture and preserving the mineral composition of the spine.…”

Section: Discussionmentioning

confidence: 96%

“…The alteration of bone structure, bone metabolism rate, endocrine system and calciumphosphorus are balanced by nutrients and natural supplements. Researchers observed that especially herbal foods can affect bone resorption and have protective roles against bone loss (Hwang et al, 2018;Zammel et al, 2018). It is possible to treat bone loss pharmacologically by inhibiting osteoclastogenesis and/or by inducing osteoblast activity.…”

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confidence: 99%

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A Preventive herb against bone loss in diabetic rats: Zingiber officinale

Suzer

Seyidoğlu

Tüfekçi

et al. 2022

Journal of Istanbul Veterinary Sciences

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The study aims to determine and compare bone mechanical and material properties in experimentally diabetic rats treated with ginger extract. Forty female, healthy Wistar albino rats were used in the study. Rats were divided into five groups; Control (C), Sham (S), Ginger (G), Diabetic (D), and Diabetic rats treated with Ginger (DG). Diabetes mellitus was induced by a single intraperitoneal injection of 50 mg/kg streptozotocin. Ginger-treated rats received 200 mg/kg ginger extract by oral gavage in a 30-day-trial. At the end of the study, tibiae were harvested and subjected to a three-point bending test. Plasma samples were also analyzed for calcium and phosphorus concentrations. It was observed that the bending strength significantly decreased in the groups Ginger (234.78 ± 16.79; P = 0.019) and the Diabetic (223.90 ± 29.90; P = 0.028) compared to group Control (275.75 ± 33.47). In addition, the bending strength of the diabetic rats treated with ginger (DG group; 251.92 ± 15.90) was also significantly higher than the rats in the Ginger and Diabetic groups (P = 0.032 and P = 0.037, respectively). Although the plasma calcium concentrations showed no differences among any of the groups, the plasma phosphorus levels decreased significantly in group Diabetic (3.47 ± 0.28; P = 0.05) compared to Control (5.11 ± 0.21). However, there was a significant increase in plasma phosphorus in group DG (4.32 ± 0.12; P = 0.05) compared to Diabetic. In conclusion, ginger extract treatment of diabetic rats improves bone material properties. The adverse effects of diabetes on the mechanical properties of the bone were prevented by using ginger extract in diabetic rats.

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Expression Profiling of Selected Immune Genes and Trabecular Microarchitecture in Breast Cancer Skeletal Metastases Model: Effect of α–Tocopherol Acetate Supplementation

et al. 2022

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Proficiencies of Zingiber officinale against spine curve and vertebral damage induced by corticosteroid therapy associated with gonadal hormone deficiency in a rat model of osteoporosis

Cited by 9 publications

References 49 publications

Ginger and Garlic Extracts Enhance Osteogenesis in 3D Printed Calcium Phosphate Bone Scaffolds with Bimodal Pore Distribution

Ginger and Garlic Extracts Enhance Osteogenesis in 3D Printed Calcium Phosphate Bone Scaffolds with Bimodal Pore Distribution

A Preventive herb against bone loss in diabetic rats: Zingiber officinale

Expression Profiling of Selected Immune Genes and Trabecular Microarchitecture in Breast Cancer Skeletal Metastases Model: Effect of α–Tocopherol Acetate Supplementation

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