Profil épidémiologique de la tuberculose au Congo Brazzaville de 2010 à 2015

Okemba-Okombi, F.H.; Ossibi-Ibara, B.; Bemba, E.L.P.; Bopaka, R.G.

doi:10.1016/j.rmr.2016.10.719

Cited by 1 publication

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“…Despite some major advances in prevention and treatment in recent years, TB remains a key infectious disease that causes many deaths every day, mostly in Asia and Africa. The Republic of Congo is among the countries with relatively high incidence of TB, with 382 new cases per 100,000 people each year [2]. The coronavirus (COVID-19) pandemic has caused dysfunction in the prevention and control measures of infectious diseases, including TB, which may have jeopardize efforts that have been made for years to reduce the incidence of this disease [3].…”

Section: Introductionmentioning

confidence: 99%

Tumor Necrosis Factor-Alpha (TNF)-308G/A and Interleukin 8(IL-8)-251C/T Polymorphisms in Pulmonary Tuberculosis Patients from Congo

Okamba¹,

Pambou²,

Etoka-Beka³

et al. 2023

OJI

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Background: Tuberculosis (TB) is one of the world's deadliest infectious diseases. Tumor necrosis factor-Alpha (TNF-α) and Interleukin 8 (IL-8) are involved in the pathogenesis of pulmonary TB (PTB). However, the contribution of polymorphisms of these cytokines to PTB susceptibility needed more investigation across geographic regions and ethnic groups. Purpose: The aim of this study was to investigate the association of the TNF-α-308 G/A and IL-8-251T/A polymorphisms with PTB risk in the Congolese population. Methods: This case-control study included 150 PTB patients and 160 control subjects. Blood samples were collected from all participants and were used for the TNF-α-308 G/A and IL-8-251T/A genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Odds ratios (OR) were calculated to estimate the potential polymorphism associations. A P level of < 0.05 was considered significant. Results: A significant difference was found between PTB patients and controls regarding the TNF-α-308AA genotype (P = 0.035) distribution. Moreover, this genotype

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Section: Introductionmentioning

confidence: 99%