Profil évolutif de la glomérulonéphrite rapidement progressive post-infectieuse de l’enfant

Jellouli, Manel; Maghraoui, Sondos; Abidi, Kamel; Hammi, Yousra; Goucha, R.; Naija, O.; Zarrouk, Chokri; Gargah, Tahar

doi:10.1016/j.nephro.2015.04.005

Cited by 6 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the literature, NS is rarely observed in post-streptococcal glomerulonephritis, although proteinuria has frequently been seen [33–35]. A link between the presentation of NS and a poor long-term prognosis has previously been shown [35, 36]. Al-Rasheed et al reported that 60% of patients with bioptically confirmed HSP nephritis had NS, but no patient had a histologically confirmed post-streptococcal GN [35].…”

Section: Discussionmentioning

confidence: 99%

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study

et al. 2019

View full text Add to dashboard Cite

BackgroundNephrotic syndrome (NS) is one of the most frequent occurring chronic kidney diseases in childhood, despite its rarely occurrence in the general population. Detailed information about clinical data of NS (e.g. average length of stay, complications) as well as of secondary nephrotic syndrome (SNS) is not well known.MethodsA nationwide ESPED follow-up study presenting the clinical course and management of children with NS in Germany.ResultsIn course of 2 years, 347 children developed the first onset of NS, hereof 326 patients (93.9%) had a primary NS, and 19 patients had a SNS (missing data in 2 cases), the majority due to a Henoch-Schönlein Purpura. Patients with steroid-resistant NS (SRNS) stayed significantly longer in hospital than children with steroid-sensitive NS (25.2 vs. 13.3 d, p < 0.001). Patients with bacterial/viral infections stayed longer in hospital (24.9 d/19.5d) than children without an infection (14.2 d/14.9 d; p < 0.001; p = 0.016). Additionally, children with urinary tract infections (UTI) (p < 0,001), arterial hypertension (AH) (p < 0.001) and acute renal failure (ARF) (p < 0,001) stayed significantly longer in hospital.Patients with SRNS had frequent complications (p = 0.004), such as bacterial infections (p = 0.013), AH (p < 0.001), UTI (p < 0.001) and ARF (p = 0.007). Children with a focal segmental glomerulosclerosis (FSGS) had significantly more complications (p = 0.04); specifically bacterial infections (p = 0.01), UTI (p = 0.003) and AH (p < 0,001). Steroid-resistance was more common in patients with UTI (p < 0.001) and in patients with ARF (p = 0.007). Furthermore, steroid-resistance (p < 0.001) and FSGS (p < 0.001) were more common in patients with AH.ConclusionsThis nationwide, largest German study presents results on the clinical course of children with NS considering a diverse range of complications that can occur with NS. The establishment of a region-wide and international pediatric NS register would be useful to conduct further diagnostic and therapy studies with the aim to reduce the complication rate and to improve the prognosis of NS, and to compare the data with international cohorts.Electronic supplementary materialThe online version of this article (10.1186/s12882-019-1233-1) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…El tratamiento se basa en el soporte de la insuficiencia renal aguda y en el tratamiento con corticoides e inmunosupresores. Se divide en dos fases: 3,4 • Fase de inducción: corticoides + ciclofosfamida.…”

Section: Conflicto De Interesesunclassified

Glomerulonefritis rápidamente progresiva de etiología posinfecciosa. Caso pediátrico

et al. 2019

View full text Add to dashboard Cite

Presentación de casos clínicos RESUMEN La glomerulonefritis rápidamente progresiva de etiología posinfecciosa es rara en la infancia, con una prevalencia estimada del 1-3 %. La mayoría debuta como insuficiencia renal aguda y su tratamiento se basa en el uso de corticoides y ciclofosfamida. Si se realiza diagnóstico precoz, el 70 % presenta una recuperación temprana de la función renal. En los últimos años, se han descrito "glomerulopatías por C3", que presentan características que se superponen. Son útiles, en el diagnóstico diferencial, la inmunofluorescencia y la determinación del factor nefrítico. Se presenta un varón de 4 años que acude por fiebre y cuadro respiratorio. Se observa microhematuria, proteinuria, descenso de filtrado glomerular y descenso de C3, y se sospecha glomerulonefritis aguda. Se realiza una biopsia, cuya microscopía óptica muestra la presencia de semilunas epiteliales, y la electrónica, depósitos subepiteliales en forma de joroba, por lo que se diagnostica glomerulonefritis rápidamente progresiva de etiología posinfecciosa.

show abstract

Glomerulonephritis

Keskinyan,

Lattanza,

Reid-Adam

2023

Pediatrics in Review

View full text Add to dashboard Cite

Glomerulonephritis (GN) encompasses several disorders that cause glomerular inflammation and injury through an interplay of immune-mediated mechanisms, host characteristics, and environmental triggers, such as infections. GN can manifest solely in the kidney or in the setting of a systemic illness, and presentation can range from chronic and relatively asymptomatic hematuria to fulminant renal failure. Classic acute GN is characterized by hematuria, edema, and hypertension, the latter 2 of which are the consequence of sodium and water retention in the setting of renal impairment. Although presenting signs and symptoms and a compatible clinical history can suggest GN, serologic and urinary testing can further refine the differential diagnosis, and renal biopsy can be used for definitive diagnosis. Treatment of GN can include supportive care, renin-angiotensin-aldosterone system blockade, immunomodulatory therapy, and renal transplant. Prognosis is largely dependent on the underlying cause of GN and can vary from a self-limited course to chronic kidney disease. This review focuses on lupus nephritis, IgA nephropathy, IgA vasculitis, and postinfectious GN.

show abstract

Profil évolutif de la glomérulonéphrite rapidement progressive post-infectieuse de l’enfant

Cited by 6 publications

References 22 publications

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study

Clinical course & management of childhood nephrotic syndrome in Germany: a large epidemiological ESPED study

Glomerulonefritis rápidamente progresiva de etiología posinfecciosa. Caso pediátrico

Glomerulonephritis

Contact Info

Product

Resources

About