Profilaxis antibiótica en cirugía oncológica faringolaríngea: ceftriaxona versus clindamicina + gentamicina

A Meta‐Analysis of Randomized, Controlled Trials Assessing the Prophylactic Use of Ceftriaxone. A Study of Wound, Chest, and Urinary Infections

“…The meta‐analysis (Table 1, Fig. 2) showed a difference in favor of ceftriaxone, which was unchanged when sensitivity analysis looking at studies with double blinding, studies with CDC definitions of infection, and studies with a Jadad score ≥4 was performed (n = 11; OR 0.73; 95% CI 0.58–0.912; p = 0.006) [6, 7, 9, 13, 16, 17, 21, 22, 25–29, 31–34, 37, 39–41, 43, 45–52, 54–56, 58–60, 62, 63, 65–70]. There was minimal heterogeneity.…”

“…1. After triage, there were 90 remaining studies that were included in the meta‐analysis [6–9, 12–96]. Of these 44 were sourced from Medline, an additional 8 from Embase, 10 from the Cochrane registers, 10 from scientific meetings, and 18 from identified references.…”

“…The comparison between ceftriaxone and other antibiotics in reducing SSI was analyzed in 64 studies ( n = 22,888 patients) [6–9, 12–70]. The funnel plot identified three studies that were on or outside the 95% confidence interval, all in favor of ceftriaxone, which were excluded from further analysis [44, 61, 64].…”