Profile of an “at cutting edge” pathology laboratory for pathological human deposits: from nanometer to in vivo scale analysis on large scale facilities

Bazin, Dominique; Lucas, Ivan T.; Rouzière, Stéphan; Elkaı̈m, Erik; Mocuta, Cristian; Réguer, Solenn; Reid, David G.; Mathurin, Jérémie; Dazzi, Alexandre; Deniset‐Besseau, Ariane; Petay, Margaux; Frochot, Vincent; Haymann, Jean‐Philippe; Letavernier, Emmanuel; Verpont, Marie-Christine; Foy, Eddy; Bouderlique, Elise; Colboc, Hester; Daudon, Michel

doi:10.5802/crchim.199

Cited by 2 publications

(2 citation statements)

References 157 publications

(153 reference statements)

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“…For all the nanomaterials presented in this contribution, the emergence of in-lab characterization techniques yielding nanometer scale structural and chemical information represents a significant opportunity to increase undersatnding of their interaction with biological tissues [157]. Two possibilities exist to perform IR spectroscopy [137] beyond the diffraction limit i.e., to bridge the resolving power gap between the micrometer and nanometer ranges.…”

Section: Perspectivesmentioning

confidence: 99%

Nanomaterials in medicine: a concise review of nanomaterials intended to treat pathology, nanomaterials induced by pathology, and pathology provoked by nanomaterials

Bazin¹

2022

Comptes Rendus. Chimie

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This contribution is a concise review of nanomaterials in medicine, those designed to treat pathology, those which are induced by pathology, and those which provoke pathology. Clearly, there is a vast family of therapeutic and medically relevant nanomaterials, to which numerous excellent journals and books are dedicated. The purpose of the first section is to illustrate the chemical complexity of research into therapeutic nanomaterials and the challenges in their characterisation. The second section treats that family of nanomaterials induced by diverse pathologies, such as metabolic disorders, infection, or cancer. Here, the challenge is to find characterisation techniques able to provide chemical information at the nanometer scale to enable and enhance early medical diagnosis. Finally, various nanomaterials injected into the human body for esthetic purposes are discussed, specifically tattoo inks which can provoke severe pathologies such as skin cancer.

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Section: Perspectivesmentioning

confidence: 99%

Nanomaterials in medicine: a concise review of nanomaterials intended to treat pathology, nanomaterials induced by pathology, and pathology provoked by nanomaterials

Bazin¹

2022

Comptes Rendus. Chimie

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“…Similar characterization techniques, applied to pathological calcifications, have unearthed clues into the dysregulated processes involved in the formation of retinal drusen ( 21 ), cardiovascular calcifications ( 22 ), and dental plaque ( 23 ). Mineral characterization techniques can even provide a diagnostic basis for disease etiology, as in kidney stones ( 24 , 25 ), and clinical integration of many of these techniques is underway or proposed ( 26 ). Thus, using techniques capable of quantifying the composition of breast microcalcifications could offer a biomineralization-based analytical axis for breast cancer diagnosis and prognosis, e.g., can specific inorganic or “entrapped” organic moieties serve as chemical indicators of cancer aggressiveness?…”

Section: Introductionmentioning

confidence: 99%

Biomineralogical signatures of breast microcalcifications

et al. 2023

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Microcalcifications, primarily biogenic apatite, occur in cancerous and benign breast pathologies and are key mammographic indicators. Outside the clinic, numerous microcalcification compositional metrics (e.g., carbonate and metal content) are linked to malignancy, yet microcalcification formation is dependent on microenvironmental conditions, which are notoriously heterogeneous in breast cancer. We interrogate multiscale heterogeneity in 93 calcifications from 21 breast cancer patients using an omics-inspired approach: For each microcalcification, we define a “biomineralogical signature” combining metrics derived from Raman microscopy and energy-dispersive spectroscopy. We observe that (i) calcifications cluster into physiologically relevant groups reflecting tissue type and local malignancy; (ii) carbonate content exhibits substantial intratumor heterogeneity; (iii) trace metals including zinc, iron, and aluminum are enhanced in malignant-localized calcifications; and (iv) the lipid-to-protein ratio within calcifications is lower in patients with poor composite outcome, suggesting that there is potential clinical value in expanding research on calcification diagnostic metrics to include “mineral-entrapped” organic matrix.

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Profile of an “at cutting edge” pathology laboratory for pathological human deposits: from nanometer to in vivo scale analysis on large scale facilities

Abstract: rendus.academie-sciences.fr/chimie/ Dominique Bazin et al.

Cited by 2 publications

References 157 publications

Nanomaterials in medicine: a concise review of nanomaterials intended to treat pathology, nanomaterials induced by pathology, and pathology provoked by nanomaterials

Nanomaterials in medicine: a concise review of nanomaterials intended to treat pathology, nanomaterials induced by pathology, and pathology provoked by nanomaterials

Biomineralogical signatures of breast microcalcifications

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