Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Gouveia, Emy Akiyama; Alves, Maria Júlia Manso; Mantovani, Elenice; Oyafuso, Luiza Keiko; Bonoldi, Virgínia Lúcia Nazário; Yoshinari, Natalino Hajime

doi:10.1590/s0036-46652010000600003

Cited by 25 publications

(29 citation statements)

References 32 publications

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“…In Brazil, a similar disease, referred as Brazilian Lyme diseasesimile illness or Baggio-Yoshinari Syndrome (BYS) has been described, since last ending century GOUVEIA et al, 2010). Mantovani et al (2007) were unable to confirm whether this syndrome is caused by new Borrelia species or it is related to genetically modified Borrelia burgdorferi sensu lato microorganisms or other infectious agent.…”

Section: Introductionmentioning

confidence: 99%

Evidence of Borrelia in wild and domestic mammals from the state of Minas Gerais, Brazil

Montandon

Yoshinari

Milagres

et al. 2014

Rev. Bras. Parasitol. Vet.

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The main of the study was to evaluate the presence of Borrelia burgdorferi infection in domestic and wild vertebrates and ectoparasites in endemic areas from the state of Minas Gerais, Brazil. A total of 445 serum samples were examined by ELISA, which used the Borrelia burgdorferi strain G39/40 U.S. source and 3,821 tick samples were tested by polymerase chain reaction (PCR). B. burgdorferi antibodies were found in 30 serum samples (6.74%); three in marsupials (7.69%), three in rodents (2.80%), nine in dogs (6.25%), and 15 in horses (9.68%). Nested-PCR performed in DNA samples obtained from collected ticks demonstrated negative results. Although attempts to amplify B. burgdorferi DNA from ticks had been not successful, the presence of seroreactive vertebrates suggests the possibility the Borrelia species circulating in these regions. Further research is required to provide information on the presence of Borrelia in Brazilian territory and its association with Baggio-Yoshinari syndrome.

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Section: Introductionmentioning

confidence: 99%

Evidence of Borrelia in wild and domestic mammals from the state of Minas Gerais, Brazil

Montandon

Yoshinari

Milagres

et al. 2014

Rev. Bras. Parasitol. Vet.

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“…In Brazil, the study of LD started in 1989 and until now much of the knowledge on Brazilian borreliosis is due to the research effort of a multidisciplinary team headed by Dr. Natalino H. Yoshinari 68 , 71. In a preliminary study of 19 patients, Yoshinari and coworkers found that 31.5% had skin lesions, 31.5% had arthritis, and 42% had neurological disorders 70.…”

Section: Discussionmentioning

confidence: 99%

Adult-onset opsoclonus-myoclonus-ataxia syndrome as a manifestation of brazilian lyme disease-like syndrome: a case report and review of literature

Lino¹,

Spera²,

Campos³

et al. 2014

ACR

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Described in 1962, the opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare, neurologically debilitating disorder with distinct characteristics that may begin in childhood or adult life. Although many cases remain without etiological diagnosis, others are related to neoplasms and infectious diseases. We report a 41-year-old previously healthy male with an 8-day history of headache, vertigo, nausea, vomiting, and nystagmus. After a normal brain computed tomography and lymphocytic pleocytosis in cerebral spinal fluid (CSF), intravenous acyclovir therapy was initiated in the emergency room. On the third day of hospitalization, the diagnosis of OMAS was made based on the presence of chaotic and irregular eye movements, dysarthric speech, gait instability, generalized tremor, and myoclonic jerks. In the face of his neurological worsening, ampicillin followed by nonspecific immunotherapy (methylprednisolone and intravenous immunoglobulin) was prescribed, with mild clinical improvement. After a thorough laboratory workup, the definite diagnosis of neuroborreliosis was established and ceftriaxone (4 g/daily/3 wks) and doxycycline (200 mg/day/2 mo) was administered. Toward the end of the ceftriaxone regimen, the neurologic signs substantially improved. We believe this to be the first case description of OMAS as clinical presentation of Brazilian Lyme disease-like syndrome (Baggio-Yoshinari syndrome).

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“…Laboratory diagnosis of BYS is difficult because serological tests (ELISA, enzyme immunosorbent assay, or western blotting) for B. burgdorferi show low sensitivity and specificity27, 28, 29, 30, 31, 32; this is because these tests utilize antigens from B. burgdorferi stricto sensu from the Northern Hemisphere to evaluate immunoglobulins of Brazilian B. burgdorferi sensu lato.…”

Section: The Disease In Humans (Ld Of the Northern Hemisphere Versus mentioning

confidence: 99%

Brazilian borreliosis with special emphasis on humans and horses

Basile

Yoshinari

Mantovani

et al. 2017

Brazilian Journal of Microbiology

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Borreliosis caused by Borrelia burgdorferi sensu lato is a cosmopolitan zoonosis studied worldwide; it is called Lyme disease in many countries of the Northern Hemisphere and Lyme-like or Baggio-Yoshinari Syndrome in Brazil. However, despite the increasing number of suspect cases, this disease is still neglected in Brazil by the medical and veterinary communities. Brazilian Lyme-like borreliosis likely involves capybaras as reservoirs and Amblyomma and Rhipicephalus ticks as vectors. Thus, domestic animals can serve as key carriers in pathogen dissemination. This zoonosis has been little studied in horses in Brazil. The first survey was performed in the state of Rio de Janeiro, and this Brazilian Borreliosis exhibits many differences from the disease widely described in the Northern Hemisphere. The etiological agent shows different morphological and genetic characteristics, the disease has a higher recurrence rate after treatment with antibiotics, and the pathogen stimulates intense symptoms such as a broader immune response in humans. Additionally, the Brazilian zoonosis is not transmitted by the Ixodes ricinus complex. With respect to clinical manifestations, Baggio-Yoshinari Syndrome has been reported to cause neurological, cardiac, ophthalmic, muscle, and joint alterations in humans. These symptoms can possibly occur in horses. Here, we present a current panel of studies involving the disease in humans and equines, particularly in Brazil.

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Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas"

Cited by 25 publications

References 32 publications

Evidence of Borrelia in wild and domestic mammals from the state of Minas Gerais, Brazil

Evidence of Borrelia in wild and domestic mammals from the state of Minas Gerais, Brazil

Adult-onset opsoclonus-myoclonus-ataxia syndrome as a manifestation of brazilian lyme disease-like syndrome: a case report and review of literature

Brazilian borreliosis with special emphasis on humans and horses

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