Profiling and hormonal therapy for acne in women

Ghosh, Shobha; Chaudhuri, Soumik; Jain, Vijay Kumar; Aggarwal, Kamal

doi:10.4103/0019-5154.127667

Cited by 16 publications

(27 citation statements)

References 58 publications

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“…Several RCTs have assessed the efficacy of COCP in the management of acne. [ 101 102 103 104 105 106 107 108 109 110 ] A 2012 Cochrane meta-analysis assessed the effect of OCPs on acne in women and included 31 trials with a total of 12,579 women. Nine trials compared a COCP to placebo and the former reduced acne in almost all women.…”

Section: Hoice Of O Ral C mentioning

confidence: 99%

Consensus statement on the use of oral contraceptive pills in polycystic ovarian syndrome women in India

Patil¹

2018

J Hum Reprod Sci

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Objective:To provide consensus recommendations for health-care providers on the use of oral contraceptive pills (OCPs) in polycystic ovarian syndrome (PCOS) women in India.Participants:Extensive deliberations, discussions, and brainstorming were done with different fraternities (specialists) being involved. These included endocrinologists, gynecologists, reproductive endocrinologists, dermatologists, public health experts, researchers, and a project manager with a team to develop the guideline.Evidence:Published literature was retrieved through searches of Medline and The Cochrane Database from January 2003 to December 2017 using appropriate-controlled vocabulary (e.g., oral contraceptive pills, polycystic ovarian syndrome, long term outcomes, infertility). Clinical practice guideline collections, clinical trial registries, and national and international medical specialty societies' publications and data were also reviewed to suggest the recommendations.Process:The working group for guideline committee included members from the PCOS Society (India), Indian Society for Assisted Reproduction, The Mumbai Obstetric and Gynecological Society, The Endocrine Society of India, Indian Association of Dermatologists, Venereologists and Leprologists, Cosmetic Dermatology Society (India), Academicians from Medical Colleges, National Institute for Research in Reproductive Health, and a Research Associate. The core team included five reproductive endocrinologists, five gynecologists, five dermatologists, three endocrinologists, two public health experts and one research associate.Conclusions:This consensus statement provides the guidance/recommendations for Indian practitioners regarding the use of OCP in women with PCOS. PCOS is one of the common endocrinopathies encountered in gynecological/endocrine practice. The spectrum of this disorder may range from prepubertal girls with premature pubarche, young girls with hirsutism, acne and anovulatory cycles, married women with infertility, and elderly women. Although obesity is a common feature for most PCOS patients, 'lean PCOS' also exists. For several years, OCPs have played an important role in the symptom management of PCOS women. This is due to the fact that OCPs decrease the luteinizing hormone, reduce androgen production, and increase sex hormone-binding globulin, which binds androgens. Several new formulations of OCPs have been developed to decrease the side effects. This includes use of less androgenic progestins and lower doses of ethinyl estradiol. These consensus recommendations help the health provider to choose the right type of OCPs, which will alleviate the symptoms with least side effects. It also gives insight into the indications, contraindications, and concerns regarding its short, intermediate and long-term use.

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Section: Hoice Of O Ral C mentioning

confidence: 99%

Consensus statement on the use of oral contraceptive pills in polycystic ovarian syndrome women in India

Patil¹

2018

J Hum Reprod Sci

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“…Acne is not caused by a hormonal misfit, but hormones, primarily androgens and related receptors, can play a role in its pathophysiology and treatment . Before puberty, the adrenal glands produce increasing amounts of dehydroepiandrosterone sulphate (DHEAS), which can be metabolized into more potent androgens in the skin, driving enlargement of the sebaceous gland and increased sebum production; this is a prerequisite for acne in all populations.…”

Section: Acne Overviewmentioning

confidence: 99%

Is hormonal treatment still an option in acne today?

Bettoli

Zauli

2015

Br J Dermatol

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SummaryHormonal treatment is indicated in cases of papulopustular, nodular and conglobate acne in females with identified hyperandrogenism, in adult women who have monthly flare-ups and when standard therapeutic options are unsuccessful or inappropriate. This review summarizes the latest information on hormonal therapies including: combined oral contraceptives; anti-androgens, such as cyproterone acetate, spironolactone and flutamide; low-dose glucocorticoids and gonadotropin-releasing hormone agonists. It also shares the authors' recommendations for treatment based on the studies discussed here, and personal experience.Acne vulgaris is a multifactorial dermatosis and increased sensitivity of the pilosebaceous unit to androgens is one of the most important pathogenetic factors. While it commonly presents alone, it can also be associated with other clinical features of hyperandrogenism and other diseases with endocrinological abnormalities. Hormonal treatment is indicated in cases of papulopustular, nodular and conglobate acne in females with identified hyperandrogenism, in adult women who have monthly flare-ups and when standard therapeutic options are unsuccessful or inappropriate. Acne overview Pathophysiology of acneAcne is not caused by a hormonal misfit, but hormones, primarily androgens and related receptors, can play a role in its pathophysiology and treatment.

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“…Clinical signs of hyperandrogenism suggesting virilism, including clitoromegaly, deepening of the voice, and increased libido, may also be present . While patients with hyperandrogenism benefit from an examination for underlying PCOS, virilism in PCOS is rare; patients presenting with virilism should be evaluated for endocrine malignancy and endocrine tumors (if viri ). Furthermore, there is a paucity of information regarding the prevalence of signs of clinical hyperandrogenism across the age spectrum in patients in PCOS.…”

Section: Rotterdam Criterion: Clinical Hyperandrogenismmentioning

confidence: 99%

Polycystic Ovary Syndrome: Special Diagnostic and Therapeutic Considerations for Children

Kamangar

Okhovat

Schmidt

et al. 2015

Pediatric Dermatology

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Polycystic ovary syndrome (PCOS) is an endocrine syndrome with variable phenotypic expression and important systemic associations and sequelae, including obesity, insulin resistance, infertility, risk of endometrial cancer, and possible risk of cardiovascular events. PCOS is recognized as a condition influenced by genetic and environmental factors and distinct manifestations in all stages of life, including the prenatal period, childhood, adolescence, and adulthood. Identification of this disorder in childhood and adolescence has received growing attention, in part because of emerging evidence of the benefit of early intervention, but the diagnosis and management of PCOS in children and adolescents can be challenging. Diagnostic and therapeutic considerations of PCOS in children are reviewed to enhance identification and evaluation of patients suspected of having this disorder. When a diagnosis of PCOS is suspected in a child but cannot be confirmed, a provisional diagnosis is strongly recommended so as to prompt ongoing monitoring with an emphasis on important early interventions such as obesity reduction.

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Profiling and hormonal therapy for acne in women

Cited by 16 publications

References 58 publications

Consensus statement on the use of oral contraceptive pills in polycystic ovarian syndrome women in India

Consensus statement on the use of oral contraceptive pills in polycystic ovarian syndrome women in India

Is hormonal treatment still an option in acne today?

Polycystic Ovary Syndrome: Special Diagnostic and Therapeutic Considerations for Children

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