Profiling of eicosanoids in inflamed gall bladder wall by gas chromatography with selected-ion monitoring

Sakurai, Toshinori; Ichimiya, Hitoshi; Miyazaki, Hiroshi; Nakayama, Fumio

doi:10.1016/0378-4347(91)80429-g

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…This is similar to previous reports in which acute cholecystitis accounts for 3-8% of GI complications following cardiac surgery [13,18,19]. The precise pathophysiology of the cholecystitis is not known, although several mechanisms have been suggested which include visceral hypoperfusion of the gallbladder, increased viscosity of bile because of the stasis, endotoxemia and overproduction of in ammatory mediators [20].…”

Section: Acute Cholecystitissupporting

confidence: 90%

Characteristics, Incidence, and Outcomes of Gastrointestinal Complications Post-Cardiac Surgery in A Quaternary Referral Centre: A Retrospective Study.

Yadav

Chapple

O’Connor

et al. 2022

Preprint

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Background:Gastrointestinal (GI) complications after cardiac surgery are associated with high morbidity and mortality. Early identification and treatment of GI complications could improve patient outcomes. The objectives of this study were to ascertain the incidence and outcomes of GI complications following cardiac surgery and to identify clinical characteristics associated with the development of GI complications in this population.Methods:A retrospective single-centre cohort study of adult patients undergoing cardiac surgery in an Australian quaternary cardiothoracic surgical referral centre from November 2012 to March 2020 was conducted. Pre-operative characteristics, and intra-operative and post-operative management were compared between patients who did or did not develop GI complications. Data are presented as n (%).Results:A total of 4417 patients underwent cardiac surgery of whom 95 (2%) developed GI complications in the post-operative period. The most common GI complication was paralytic ileus (n=22, 22%), while mesenteric ischemia (n=16, 16%) was associated with the highest all-cause mortality (n=7, 44%). Pre-operative factors associated with GI complications included age >70 years, creatinine >200 microgram/ml, pre-operative arrhythmia, and illness severity (Acute Physiology and Chronic Health Evaluation II and III score). The intra-operative factor associated with GI complications was a cardiopulmonary bypass time >120 mins. Post-operative factors associated with GI complications included red blood cell transfusion, stroke, new-onset renal failure, cardiogenic shock, ventilation >24 hours, re-intubation, septic shock, and multiorgan failure. Conclusions:Multiple risk factors associated with GI complications in patients undergoing cardiac surgery were identified. These provide potential targets to support early detection and management of GI complications in order to reduce morbidity and mortality in these patients.

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Section: Acute Cholecystitissupporting

confidence: 90%

Characteristics, Incidence, and Outcomes of Gastrointestinal Complications Post-Cardiac Surgery in A Quaternary Referral Centre: A Retrospective Study.

Yadav

Chapple

O’Connor

et al. 2022

Preprint

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“…Diabetics are at increased risk for developing acalculous cholecystitis likely secondary to small vessel vascular disease and gallbladder dysmotility 72 . Many factors have been thought to be involved in the pathogenesis of postcardiac surgery acute cholecystitis including endotoxemia, overproduction of regional inflammatory mediators, visceral hypoperfusion, and increased bile viscosity 73,74 . Sepsis appears to be a major risk for cholecystitis.…”

Section: Off‐pump Cabgmentioning

confidence: 99%

“…72 Many factors have been thought to be involved in the pathogenesis of postcardiac surgery acute cholecystitis including endotoxemia, overproduction of regional inflammatory mediators, visceral hypoperfusion, and increased bile viscosity. 73,74 Sepsis appears to be a major risk for cholecystitis. In nontransplant cardiac surgery acalculous cholecystitis is as frequent as calculous cholecystitis.…”

Section: Acute Cholecystitismentioning

confidence: 99%

Gastrointestinal Complications following Cardiac Surgery: A Comprehensive Review

Rodríguez¹,

Robich

Plate³

et al. 2010

Journal of Cardiac Surgery

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“…Usually the cholecystis are acalculous and pathophysiology is still unclear. Visceral hypoperfusion, endotoxemia, and overproduction of inflammatory mediators have been suggested as mechanisms for AC [23]. In our patients, 3 of them were diagnosed in an average of 10 to 15 days.…”

Section: Witch Are the Major Factors Influencing In Gics?mentioning

confidence: 67%

Gastrointestinal Complications Following Cardiac Surgery.

Ibrahimi

Kuçi

Bejko

et al. 2019

AJTES

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Purpose: gastrointestinal complication (GIC) following open heart surgery usually are rare but with high morbidity and mortality. The aim of this study was to see the outcome of these patients after complication, compared with a similar study found in literature. Identifying risk factors preoperatively and postoperatively in our patient’s series, for GIC.Materials and methods: Between January 2012 and December 2017 from 1990 operated cardiac patient 34 of them developed GIC, presenting gastro duodenal bleeding due to active ulcer, liver failure, pancreatitis, cholecystitis, or intestinal ischemia. We performed a retrospective analysis.Results: From all consecutive patient only 1.7 % developed GIC. Mortality rate was 55.8%, especially 100 % mortality in intestinal ischemia patient. Regarding risk factors, those were the same found in other similar study (age, atherosclerosis disease, by pass time, postoperative ARF, Low cardiac output syndrome.)Conclusion: GIC after cardiac surgery are rare but when it happens the mortality is very high not even of late diagnosis. In ages patients, diabetes, long by pass time, long hypoperfusion state. It is recommended to be alert for GIC for detection in early phase, and for reducing as much as possible morbidity and mortality.

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Profiling of eicosanoids in inflamed gall bladder wall by gas chromatography with selected-ion monitoring

Cited by 6 publications

References 27 publications

Characteristics, Incidence, and Outcomes of Gastrointestinal Complications Post-Cardiac Surgery in A Quaternary Referral Centre: A Retrospective Study.

Characteristics, Incidence, and Outcomes of Gastrointestinal Complications Post-Cardiac Surgery in A Quaternary Referral Centre: A Retrospective Study.

Gastrointestinal Complications following Cardiac Surgery: A Comprehensive Review

Gastrointestinal Complications Following Cardiac Surgery.

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