Profound leukemia cutis in a patient with relapsed T-cell acute lymphoblastic leukemia

Nohria, Ambika; Criscito, Maressa C.; Weston, Gillian; Kim, Randie H.; Sicco, Kristen I. Lo; Femia, Alisa; Hejazi, Emily Z.; Milam, Emily C.

doi:10.1016/j.jdcr.2021.10.013

Cited by 4 publications

(14 citation statements)

References 9 publications

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“…Although a few cases of LC in T-ALL were reported in the literature from 1999 to 2021 (4,6,(8)(9)(10)(11), only one neonate has been described with a follow-up of 2 years after treatment, and no detailed records of treatment and follow-up in adult patients have been found (11). This case is the first described with a favorable evolution after a 3-year follow-up.…”

Section: Discussionmentioning

confidence: 88%

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Zhang

Wang

2023

Ann Palliat Med

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Herein, we report a case of a female patient with T-cell acute lymphoblastic leukemia (T-ALL) who presented with LC and was in excellent clinical condition during a 3-year follow-up after treatment with chemotherapy and allogeneic stem cell transplantation. We present the following case in accordance with the CARE reporting checklist (available at https://apm. amegroups.com/article/view/10.21037/apm-22-665/rc).

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Section: Discussionmentioning

confidence: 88%

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Zhang

Wang

2023

Ann Palliat Med

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“…Patients with underlying hematologic malignancies can present with a diversity of non-specific reactive skin lesions or specific infiltrates. 3 Leukemia cutis is a cutaneous infiltration of neoplastic leukocytes, which has multiple clinical presentations including erythematous papules, nodules, plaques, bullae, noduloulcerative lesions, and even erythroderma. 3 The lesions are often firm or/and hemorrhagic lesions.…”

Section: Discussionmentioning

confidence: 99%

“…The most common locations are face, head, neck, and trunk. 3 In addition to usual typical skin manifestations, the recorded unusual manifestations of leukemia cutis were summarized in retrospective study in 2021 by Yung-WeiChang, which included leonine faces, figurate cutaneous lesions, fingertip hypertrophy, erythema nodosum, guttate psoriasis, chronic paronychia, leukemic vasculitis, and Sister Mary Joseph's nodule. 4 Our patient was complaining of hyperpigmented patches on the face and upper trunk from 6 months before presenting to our clinic, and unfortunately, the patches were treated as skin pigmentation.…”

Section: Discussionmentioning

confidence: 99%

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Leukemia cutis presenting as hyperpigmented patches. A rare presentation

Namazi

Kani

Kaddah

et al. 2022

Clinical Case Reports

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“…Skin changes are mainly located in the trunk, extremities and face [15,17,18]. Widespread petechiae-like eruptions secondary to LC have also been rarely described [23]. Although skin lesions are usually generalized, some solitary, clustered, or dispersed lesions have also been observed [2].…”

Section: Diagnosismentioning

confidence: 99%

Leukemia Cutis—the Current View on Pathogenesis, Diagnosis and Treatment

Robak,

Braun,

Robak

2023

Preprint

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Leukemia cutis (LC) is defined as leukemic infiltration of the epidermis, the dermis, and the subcutaneous tissue. Leukemia cutis may follow or occur simultaneously with the diagnosis of systemic leukemia. However, cutaneous lesions are occasionally diagnosed as the primary manifestation of leukemia. Leukemic skin infiltrations demonstrate considerable variation regarding number of changes, distribution, and morphology. The highest incidence of LC is observed in chronic lymphocytic leukemia, monocytic and myelomonocytic acute myeloid leukemia, and in T-cell lineage leukemia. Although the pathogenic mechanism of the invasion of leukemic cells into the skin is not well understood, chemokine receptors and adhesion molecules as well as genetic characteristics of leukemia are thought to play a role. Leukemic skin lesions may be localized or disseminated and may occur alone or in combination on any site of the skin, most frequently in the trunk and extremities. The most common clinical presentations of leukemia cutis are papules, nodules, macules, plaques, and ulcers. In most patients, complete or partial resolution of cutaneous infiltrations occurs simultaneously with hematologic remission. However, in patients with resistant disease or recurrent skin infiltration, local radiotherapy can be used. This review presents recent data on the pathogenesis, diagnosis and treatment of leukemic skin involvement in different types of leukemia

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Profound leukemia cutis in a patient with relapsed T-cell acute lymphoblastic leukemia

Cited by 4 publications

References 9 publications

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Leukemia cutis in T-cell acute lymphoblastic leukemia: a 3-year follow-up case report

Leukemia cutis presenting as hyperpigmented patches. A rare presentation

Leukemia Cutis—the Current View on Pathogenesis, Diagnosis and Treatment

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