Progenitor cells of the olfactory receptor neuron lineage

Calof, Anne L.; Bonnin, Alexandre; Crocker, Candice E.; Kawauchi, Shimako; Murray, Richard C.; Shou, Jianyong; Wu, Hao

doi:10.1002/jemt.10147

Cited by 130 publications

(122 citation statements)

References 77 publications

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“…These opposing effects are likely controlled by activation of different receptors. Inactivation of Bmpr1b prevents the reduction of neurogenesis induced by BMP-7, whereas the effects of BMP-4 remain unaltered (Calof et al 2002). Both BMPRIA and BMPRIB are expressed in the olfactory epithelium and, whereas BMP-4 and BMP-7 signal through BMPRIB, BMP-4 signals through BMPRIA (ten Dijke et al 1994), suggesting that BMPRIA exerts a survival effect.…”

Section: The Retina and Olfactory Epitheliummentioning

confidence: 99%

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Meyers

Kessler

2017

Cold Spring Harb Perspect Biol

137

107

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Section: The Retina and Olfactory Epitheliummentioning

confidence: 99%

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Meyers

Kessler

2017

Cold Spring Harb Perspect Biol

137

107

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“…1A): (1) stem cells, which give rise to (2) transit amplifying progenitors that express Mammalian Achaete Scute Homolog 1 (Mash1), a proneural gene; Mash1 positive (+) cells give rise to (3) a second transit amplifying progenitor, the immediate neuronal precursor (INP), which is distinguished by expression of the proneural gene Neurogenin1 (Ngn1). The INP divides to give rise to daughter cells that differentiate into ORNs [2]. The OE also contains supporting or sustentacular (SUS) cells, analogous to glial cells of the brain [3].…”

Section: Introductionmentioning

confidence: 99%

Identification and molecular regulation of neural stem cells in the olfactory epithelium

Beites

Kawauchi

Crocker

et al. 2005

Experimental Cell Research

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238

234

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The sensory neurons that subserve olfaction, olfactory receptor neurons (ORNs), are regenerated throughout life, making the neuroepithelium in which they reside [the olfactory epithelium (OE)] an excellent model for studying how intrinsic and extrinsic factors regulate stem cell dynamics and neurogenesis during development and regeneration. Numerous studies indicate that transcription factors and signaling molecules together regulate generation of ORNs from stem and progenitor cells during development, and work on regenerative neurogenesis indicates that these same factors may operate at postnatal ages as well. This review describes our current knowledge of the identity of the OE neural stem cell; the different cell types that are thought to be the progeny (directly or indirectly) of this stem cell; and the factors that influence cell differentiation in the OE neuronal lineage. We review data suggesting that (1) the ORN lineage contains three distinct proliferating cell types-a stem cell and two populations of transit amplifying cells; (2) in established OE, these three cell types are present within the basal cell compartment of the epithelium; and (3) the stem cell that gives rise ultimately to ORNs may also generate two glial cell types of the primary olfactory pathway: sustentacular cells (SUS), which lie within OE proper; and olfactory ensheathing cells (OEC), which envelope the olfactory nerve. In addition, we describe factors that are both made by and found within the microenvironment of OE stem and progenitor cells, and which exert crucial growth regulatory effects on these cells. Thus, as with other regenerating tissues, the basis of regeneration in the OE appears be a population of stem cells, which resides within a microenvironment (niche) consisting of factors crucial for maintenance of its capacity for proliferation and differentiation. D

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“…9,[11][12][13] The OE contains a developmentally dynamic neuronal population comprised of globose basal cells, neuronal precursors, and immature and mature OSNs. 14 Sustentacular support cells provide many of the extrinsic factors that regulate the dynamics of the neuronal population. [15][16][17] Neurogenesis is hypothesized to begin with exposure of globose basal cells to external signals that direct them to undergo a single round of asymmetric division producing a progenitor cell that migrates apically out of basal cell layer.…”

Section: Introductionmentioning

confidence: 99%

Progressive and Inhibitory Cell Cycle Proteins Act Simultaneously to Regulate Neurotrophin-mediated Proliferation and Maturation of Neuronal Precursors

Simpson

Moon²,

Kleman

et al. 2007

Cell Cycle

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ACKnowlEdGEMEntSWe thank Amy Palmer for helpful discussions and reading of the manuscript, and Susan McTeer for manuscript preparation. This work was supported by grants NIDCD RO3 DC005704 to P.J.S., NIDCD RO1 DC02979 and NINDS RO1 NS39657 to G.V.R. AbStRACtNeuronal stem cell expansion and differentiation is a process involving stages of proliferation and maturation governed by the sequential and combinatorial exposure of cells to extrinsic factors. The olfactory epithelium is an excellent model to investigate regulation of this process, as it undergoes neuronal replacement post-natally. We have shown that the neurotrophins NGF and BDNF sequentially promote proliferation of developing olfactory sensory neuronal precursors, although their kinetics of proliferation and cell fate outcomes differ. Interestingly, CNP inhibits this neurotrophin-induced proliferation and promotes the maturation of these precursors to their next developmental stage. Here, we investigate the mechanisms behind these actions. Both NGF and BDNF increase the expression of cyclin D1 and cyclin-dependent kinase 4 (cdk4), with temporal expression patterns that parallel the proliferation kinetics of their cellular targets. The timing of cyclin D1 expression reflects differences in the need for transcription and translation in early and late stage precursors. CNP inhibits neurotrophin-induced cyclin D1 expression, and induces the expression of different profiles of inhibitory cell cycle proteins, which are neurotrophin-specific and correlate with the attainment of different maturational cell fates. Inhibition of protein degradation reverses the effects of neurotrophins and CNP on cyclin D1 and inhibitor expression levels, respectively. These results suggest a model for cell cycle regulation that involves the simultaneous expression of progressive and inhibitory cell cycle regulatory proteins in response to both proliferation and differentiation agents, followed by selective degradation of these proteins, providing a mechanism for rapid and exquisite control of the cell cycle.

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Progenitor cells of the olfactory receptor neuron lineage

Cited by 130 publications

References 77 publications

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Identification and molecular regulation of neural stem cells in the olfactory epithelium

Progressive and Inhibitory Cell Cycle Proteins Act Simultaneously to Regulate Neurotrophin-mediated Proliferation and Maturation of Neuronal Precursors

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