Progesterone: Biphasic Effects on the Lordosis Response in Adult or Neonatally Gonadectomized Rats

Rd, Lisk

doi:10.1159/000121857

Cited by 38 publications

(23 citation statements)

References 4 publications

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“…Thus, both Lisk [56] and Gerall et al [35] reported that female rats which were ovariectomized on the day of birth had lower lordosis quotients after adult treatment with estradiol and progesterone than females which either kept their ovaries [56] or were ovariectomized at birth and subsequently implanted with ovaries from the day of birth until day 60 [35]. In addition, neonatally castrated male rats implanted with ovaries at several different periods between birth and day 60 showed higher lordosis quotients than neonatally castrated males which were not given ovarian implants [29,35].…”

Section: The Role Of the Ovary In Female Sexual Differentiationmentioning

confidence: 97%

Role for estradiol in female-typical brain and behavioral sexual differentiation

Bakker

Baum

2008

Frontiers in Neuroendocrinology

170

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The importance of estrogens in controlling brain and behavioral sexual differentiation in female rodents is an unresolved issue in the field of behavioral neuroendocrinology. Whereas, the current dogma states that the female brain develops independently of estradiol, many studies have hinted at possible roles of estrogen in female sexual differentiation. Accordingly, it has been proposed that a-fetoprotein, a fetal plasma protein that binds estrogens with high affinity, has more than a neuroprotective role and specifically delivers estrogens to target brain cells to ensure female differentiation. Here, we review new results obtained in aromatase and a-fetoprotein knockout mice showing that estrogens can have both feminizing and defeminizing effects on the developing neural mechanisms that control sexual behavior. We propose that the defeminizing action of estradiol normally occurs prenatally in males and is avoided in fetal females because of the protective actions of a-fetoprotein, whereas the feminizing action of estradiol normally occurs postnatally in genetic females.

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Section: The Role Of the Ovary In Female Sexual Differentiationmentioning

confidence: 97%

Role for estradiol in female-typical brain and behavioral sexual differentiation

Bakker

Baum

2008

Frontiers in Neuroendocrinology

170

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“…In rats, lordosis is a reflexive receptive posture made by the female in response to male mounting and is a hallmark indication of sexual receptivity. Whereas circulating estrogens play an essential role in stimulating lordosis in females (Davidson and Bloch, 1969; Lisk, 1969; Komisaruk and Diakow, 1973; Pfaff, 1999; Pfaff and Sakuma, 1979), males rarely display lordosis behavior even after estrogen administration in adulthood (Yamanouchi and Aria, 1976). However, neonatal steroid hormone manipulation can retain in the capacity to evoke lordosis in males, and suppress proceptive behavioral displays by females, indicating that sex-specific behaviors are also organized by steroid hormones in the perinatal period (Gerall, 1967; Gorski, 1963, 1985; Grady et al, 1965; Sodersten, 1978; Patisaul et al, 2009a; Whalen and Nadler, 1963; Whales et al, 1986).…”

Section: Organization Of Reproductive Neuroendocrine Circuitsmentioning

confidence: 99%

Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior

Patisaul

Adewale

2009

Front. Behav. Neurosci.

208

139

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It is well established that, over the course of development, hormones shape the vertebrate brain such that sex specific physiology and behaviors emerge. Much of this occurs in discrete developmental windows that span gestation through the prenatal period, although it is now becoming clear that at least some of this process continues through puberty. Perturbation of this developmental progression can permanently alter the capacity for reproductive success. Wildlife studies have revealed that exposure to endocrine disrupting compounds (EDCs), either naturally occurring or man made, can profoundly alter reproductive physiology and ultimately impact entire populations. Laboratory studies in rodents and other species have elucidated some of the mechanisms by which this occurs and strongly indicate that humans are also vulnerable to disruption. Use of hormonally active compounds in human medicine has also unfortunately revealed that the developing fetus can be exposed to and affected by endocrine disruptors, and that it might take decades for adverse effects to manifest. Research within the field of environmental endocrine disruption has also contributed to the general understanding of how early life experiences can alter reproductive physiology and behavior through non-genomic, epigenetic mechanisms such as DNA methylation and histone acetylation. These types of effects have the potential to impact future generations if the germ line is affected. This review provides an overview of how exposure to EDCs, particularly those that interfere with estrogen action, impacts reproductive physiology and behaviors in vertebrates.

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“…Further, they found that male rats castrated at birth and given ovarian implants exhibited more female sexual behavior as adults than males which had only been castrated. Other evidence for the influences of ovarian tenancy on sexual behavior is provided by Lisk (1969), who found that neonatally gonadectomized female rats were less sensitive to estrogen priming than females who retained their ovaries through puberty. Moreover, prepuberal ovariectomy permanently affects the electrical activity of limbic structures in that the cyclic changes are not as clearly reestablished by exogenous hormones in female rats gonadectomized neonatally as compared to postpuberally gonadectomized females (Terasawa & Timiras, 1968).…”

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confidence: 99%

Ovarian influences on the development of sexual behavior in neonatally androgenized rats

Hendricks

Duffy

1974

Developmental Psychobiology

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Female sexual behavior was studied in male and female rats. Males were castrated on the day of birth (Day 1); some received ovarian implants at that time; others were injected on Day 3 with oil, 5 pg testosterone propionate (TP), or 50 pg TP. Females were ovariectomized at birth, 20, or 60 days of age; on Day 3 all were injected with oil, 5 pg TP, or 50 pg TP. Prepuberal ovarian tenancy in females tended to counteract the effects on sexual receptivity of TP administered during neonatal life. In males ovarian implants facilitated female sexual behavior at adulthood in oil-injected animals, but did not significantly influence the effect on neonatally injected TP. Gerall, Dunlap, and Hendricks (1973) presented evidence that the ovary present in a developing rat influences its potential to display female sexual behavior at maturity. Specifically, they found that females ovariectomized prepuberally exhibited less sexual receptivity in response to exogenously administered estrogen and progesterone than subjects ovariectomized postpuberally. Further, they found that male rats castrated at birth and given ovarian implants exhibited more female sexual behavior as adults than males which had only been castrated. Other evidence for the influences of ovarian tenancy on sexual behavior is provided by Lisk (1969), who found that neonatally gonadectomized female rats were less sensitive to estrogen priming than females who retained their ovaries through puberty. Moreover, prepuberal ovariectomy permanently affects the electrical activity of limbic structures in that the cyclic changes are not as clearly reestablished by exogenous hormones in female rats gonadectomized neonatally as compared to postpuberally gonadectomized females (Terasawa & Timiras, 1968).An interesting contrast in the data presented by was the influence of the prepuberal ovary in males as compared to females. The difference in female behavior between males castrated at birth and given ovarian implants and males only castrated was much greater than the difference between females ovariectomized during neonatal life and those ovariectomized just prior to or after puberty. This differential effect suggests one possibility as to the mechanism by which prepuberal ovarian tenancy influences potential to exhibit female sexual behavior. In terms of its sexual behavior, the

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Progesterone: Biphasic Effects on the Lordosis Response in Adult or Neonatally Gonadectomized Rats

Cited by 38 publications

References 4 publications

Role for estradiol in female-typical brain and behavioral sexual differentiation

Role for estradiol in female-typical brain and behavioral sexual differentiation

Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior

Ovarian influences on the development of sexual behavior in neonatally androgenized rats

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