Progesterone for Prevention of Recurrent Preterm Labor after Arrested Preterm Labor- A Randomized Controlled Trial

The Efficacy of Progesterone Therapy for the Prevention of Preterm Labor in Women with Mixed Risk-factors: A Systematic Review and Meta-analysis of Randomized Clinical Trials

“…Birth at 28-31 weeks is defined as very premature birth, which accounts for less than 1% of all deliveries and about 10% of all preterm births. Birth at 32-33 and 34-36 weeks of gestation are called mild and moderate preterm birth, respectively, which account for the majority (85%) of all preterm births (1)(2)(3)(4)(5)(6)(7)(8)(9). Annually, about 13 million babies are born as premature worldwide.…”

“…Studies show that the risk of death in preterm infants is more than 40 times higher than that in other babies (5). Although advances in recent decades has increased the survival chance of premature infants, the survived prematurely born babies is more likely to experience long-term health problems during their lives (7)(8)(9)(10)(11)(12)(13)(14). Also, the financial burden of preterm birth is another important negative consequence.…”

“…After identifying at-risk pregnant women, the effective interventions should be applied to treat and prevent preterm delivery. So far, the treatment with a variety of different drugs has been the first method of preventing from preterm delivery occurrence among at-risk women (7). For this, in the past decades, a large number of different drugs with different pharmacology formulas has been introduced, but the progestin drugs has been the most effective ones in the prevention of preterm labor (7,14,18).…”

“…So far, the treatment with a variety of different drugs has been the first method of preventing from preterm delivery occurrence among at-risk women (7). For this, in the past decades, a large number of different drugs with different pharmacology formulas has been introduced, but the progestin drugs has been the most effective ones in the prevention of preterm labor (7,14,18). So, today, progestins that are available in various forms are the first prescription of clinicians for the women who have the risk factors of preterm delivery.…”

“…So, today, progestins that are available in various forms are the first prescription of clinicians for the women who have the risk factors of preterm delivery. Therefore, in the recent decades, many studies have been done to evaluate the efficacy, side effects, and other aspects of progestins in the management of preterm birth (1,3,7,11,14,18). Although in many cases, the efficacy of these drugs has been approved, but many researchers and clinicians believe that the efficacy of these drugs in the prevention of preterm birth in women with single risk factor is different from that of women with multiple risk factors.…”