Progesterone receptor antagonists (antiprogestins)

Steroid Hormones

“…Many selective progesterone receptor modulators, characterized as full progesterone receptor antagonists or mixed agonist-antagonists have been designed [111][112][113][114][115][116][117][118][119][120][121][122][123][124]. The receptors also are targets for compounds that can modulate progesterone-dependent events.…”

Array synthesis of progesterone receptor antagonists: 3-Aryl-1,2-diazepines

“…1 The PR antagonist mifepristone (RU-486) is prescribed for termination of pregnancy and also offers promise for the treatment of endometriosis, uterine fibroids, and breast cancer. 2 Recently, non-steroidal PR antagonists and partial agonists have been identified with improved reproductive tissue safety profiles. 3,4 Nevertheless, new chemotypes that are amenable to high-throughput synthesis are useful to further structural understanding of PR modulation.…”