Progesterone receptor is involved in 2,3,7,8-tetrachlorodibenzo- p -dioxin-stimulated breast cancer cells proliferation

Chen, Yun Ju; Hung, Chao Ming; Kay, Nari; Chen, Chin Chen; Kao, Ying-Hsien; Yuan, Shyng‐Shiou F.

doi:10.1016/j.canlet.2012.01.017

Cited by 21 publications

(15 citation statements)

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“…It mediates most of the toxic responses of TCDD, including tumorigenic, immune, developmental, and endocrine effects (Mimura and Fujii-Kuriyama, 2002). Several studies in MCF-7 cells revealed that TCDD stimulates cell proliferation through acceleration of cell cycle progression (Chen et al, 2012), which is in agreement with our results (Figure 1 and Figure 2). Licorice root is a widely used traditional Chinese herb that has already been identified by the National Cancer Institute (Craig, 1999) as having chemopreventive attributes.…”

Section: Discussionsupporting

confidence: 93%

Tumorigenic Effects of Endocrine-disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

Chu

Cruz²,

Hwang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 93%

Tumorigenic Effects of Endocrine-disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

Chu

Cruz²,

Hwang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The procedures of protein extraction and immunoblotting were performed as described previously (20). MDA-MB-231 and MCF7 cells were treated with different concentrations of visfatin (0-100 ng/mL) for 2 hours before the immunoblotting analysis.…”

Section: Immunoblottingmentioning

confidence: 99%

Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation

Hung

Hou

et al. 2016

Clinical Cancer Research

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Purpose: Visfatin is an adipocytokine involved in cellular metabolism, inflammation, and cancer. This study investigated the roles of extracellular visfatin in breast cancer, and explored underlying mechanisms in clinical and experimental settings.Experimental Design: Associations of serum visfatin with clinicopathologic characteristics and patient survival were assessed with Cox regression models and Kaplan-Meier analyses. Effects of extracellular visfatin on cultured breast cancer cells were examined, followed by in vivo investigation of tumor growth and metastasis in xenograft animal models. Imatinib and Stattic were used to inhibit c-Abl and STAT3 activation, respectively.Results: Breast cancer patients with high serum visfatin levels were associated with advanced tumor stage, increased tumor size and lymph node metastasis, and poor survival. Elevated phosphorylation of c-Abl and STAT3 in breast tumor tissues were correlated with high serum visfatin levels in patients. Visfatinpromoted in vitro cell viability and metastatic capability were suppressed by imatinib (c-Abl inhibitor) and Stattic (STAT3 inhibitor). Increased in vivo cell invasiveness was observed in zebrafish xenografted with visfatin-pretreated breast cancer cells. Tumor growth and lung metastasis occurred in visfatin-administered mice xenografted with breast cancer cells. Tail vein-injected mice with visfatin-pretreated breast cancer cells showed increased lung metastasis, which was suppressed by imatinib.Conclusions: Serum visfatin levels in breast cancer patients reveal potential prognostic values, and our findings that visfatin promoted breast cancer through activation of c-Abl and STAT3 may provide an important molecular basis for future design of targeted therapies that take into account different serum visfatin levels in breast cancer.

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“…Both PR and ER control normal breast development and are implicated in the etiology of breast cancer (Brisken and O'Malley 2010). The functional impact of PR in promoting MCF7 cell proliferation has been proven elsewhere (Chen et al, 2012).…”

Section: Discussionmentioning

confidence: 90%

Monitoring proliferative activities of hormone-like odorants in human breast cancer cells by gene transcription profiling and electrical impedance spectroscopy

Pick

Terrettaz

Baud

et al. 2013

Biosensors and Bioelectronics

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a b s t r a c tThe human estrogen receptor alpha (ERα) mediates the proliferative action of hormones in breast cancer cells by regulating the expression of target genes to control cellular functions. Current methodologies do not permit a real-time assessment of these processes in living cells. We overcome this limitation using electrical cell-substrate impedance sensing for measuring ERα-regulated signaling processes indicative of the onset of cell proliferation to target them for compound screenings. We report that hormone like odorants regulate, similarly as natural estrogen, ERα-mediated gene expression involved in mitogenic and developmental processes in MCF7 breast cancer cells. An odorant concentration-dependent switch in cell responses was detectable already 10-15 h post-stimulation, providing rapid quantification of hormonal activity before cell division occurred. Though ERα exhibits complex regulatory roles our noninvasive approach captures its activity for accelerated screenings of compounds promoting breast cancer cell proliferation expanding the analysis of ERα signaling networks.

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Progesterone receptor is involved in 2,3,7,8-tetrachlorodibenzo- p -dioxin-stimulated breast cancer cells proliferation

Cited by 21 publications

References 50 publications

Tumorigenic Effects of Endocrine-disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

Tumorigenic Effects of Endocrine-disrupting Chemicals are Alleviated by Licorice (Glycyrrhiza glabra) Root Extract through Suppression of AhR Expression in Mammalian Cells

Extracellular Visfatin-Promoted Malignant Behavior in Breast Cancer Is Mediated Through c-Abl and STAT3 Activation

Monitoring proliferative activities of hormone-like odorants in human breast cancer cells by gene transcription profiling and electrical impedance spectroscopy

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