Progesterone Receptor (PGR) Gene Variants Associated with Breast Cancer and Associated Features: a Case-Control Study

Ghali, Rabeb M; Al-Mutawa, Maryam A; Ebrahim, Bashayer H.; Jrah, Hanen H; Zaied, Sonia; Bhiri, Hanen; Hmila, Fahmi; Mahjoub, Touhami; Almawi, Wassim Y.

doi:10.1007/s12253-017-0379-z

Cited by 20 publications

(9 citation statements)

References 30 publications

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“…Patients carrying rs1042838 A allele had higher risk of breast cancer and the allele was associated with Her2 status. [23,24]. PGR rs1042838 also appeared to be a risk factor for endometrial cancer (allele A increases the risk) [25].…”

Section: Discussionmentioning

confidence: 98%

Genetic Factors of Idiopathic Gigantomastia: Clinical Implications of Aromatase and Progesterone Receptor Polymorphisms

Kasielska‐Trojan

Pietrusiński

Bugaj-Tobiasz³

et al. 2022

JCM

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The role of estrogen, progesterone, their receptors and aromatase in the development of the breast is well documented. In this study we examined the association of genetic variants of progesterone receptor (PGR) and aromatase (CYP19A1) genes with gigantomastia risk. We conducted a case-control study among 124 women: 60 with gigantomastia and 64 controls. We examined the single nucleotide polymorphisms (SNPs) for CYP19A1 (rs749292 and rs7172156) and PGR (rs1042838). Our results showed that allele G in rs749292 (CYP19A1) increased the risk of gigantomastia, but not significantly (p = 0.09). There is a correlation between rs1042838 (PGR) and waist-to-hip ratio (WHR) in women with gigantomastia-AC genotype correlates with lower WHR and CC with higher WHR. There were no correlations between the onset of gigantomastia, the age of menarche and the length of the menstrual cycle, and rs1042838, rs749292 and rs7172156. We did not find differences in the SNP of PGR (rs1042838) between women with gigantomastia and controls. However, our findings showed more frequent G allele in CYP19A1 (rs749292) in women with gigantomastia.

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Section: Discussionmentioning

confidence: 98%

Genetic Factors of Idiopathic Gigantomastia: Clinical Implications of Aromatase and Progesterone Receptor Polymorphisms

Kasielska‐Trojan

Pietrusiński

Bugaj-Tobiasz³

et al. 2022

JCM

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“…However, there is a need to further understand the effects of the PGR rs1042838 modification with methylmercury and other environmental exposures. Of note, some recent studies detected an increased risk of breast cancer and endometrial cancer among rs1042838 minor variant carriers (44, 47), but they did not assess any potential effect modification by environmental factors.…”

Section: Discussionmentioning

confidence: 99%

A Birth Cohort Study about the Genetic Modification of Prenatal Methylmercury Association with Child Cognitive Development

Júlvez

Smith²,

Ring

et al. 2019

American Journal of Epidemiology

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Genetic predisposition may affect neurodevelopmental outcomes of prenatal methylmercury exposure. We examined suspected heterogeneities for modification of exposure-related neurodevelopment in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, 1991-2000), Bristol, United Kingdom. A subgroup (n = 1127 from a pilot study and 1045 from the present study) was identified based on the availability of the mercury concentration of cord tissue as a measure of prenatal methylmercury exposure, data on 247 single-nucleotide polymorphisms (SNPs), as well as the Wechsler Intelligence Scale for Children Intelligence Quotient (IQ) scores. Log10-transformed mercury concentration was positively associated with IQ, but adjustment confounding cofactors attenuated this association. Enhanced interaction with methylmercury was replicated in the new study for the minor allele of rs1042838 (progesterone receptor) (Beta; 95% Confidence Interval) = (-11.8; -23.0, -0.6) (P-for-interaction = 0.004) and weakly for rs662 (paraoxonase 1) (-3.6; -11.4, 4.3) (P = 0.117). In the joint sample, new interacting single-nucleotide polymorphisms (SNPs) were discovered in relation to superoxide dismutase 2, ATP binding cassette subfamily A member 1, and metallothionein 1M genes. While the low-level prenatal exposure to methylmercury was not associated with child cognition, progesterone receptor rs1042838 minor alleles revealed a negative association of mercury exposure with IQ.

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“…PGR is a ligand-activated nuclear transcription factor that mediates progesterone activity; it is the most important prognostic and predictive immunoinflammatory marker in breast cancer ( 35 ). The variants of PGR were found to be associated with increased breast cancer susceptibility ( 36 ). FASN is involved in the de novo lipogenesis and regulation of ERα signaling ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

Exploring the molecular targets and mechanisms of [10]-Gingerol for treating triple-negative breast cancer using bioinformatics approaches, molecular docking, and in vivo experiments

Huang¹,

Zhou²,

Liang³

et al. 2021

Transl Cancer Res TCR

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Background: Triple-negative breast cancer (TNBC) is the most aggressive among breast cancer subtypes with the worst prognosis. Ginger is widely used in pharmaceuticals and as food. Its anticancer properties are known, but the mechanism is still unclear. [10]-Gingerol is one of the main phenolic compounds isolated from ginger. Studying the biological effects of [10]-Gingerol is of great significance to understand the efficacy of ginger.Methods: In this study, the therapeutic effects of [10]-Gingerol on TNBC cells were studied using network pharmacology, molecular docking, and in vitro experiments, and the target and mechanism of action were explained.Results: A total of 48 targets of ginger for the treatment of TNBC were found. These targets might interfere with the growth of TNBC by participating in many pathways, such as endocrine resistance, progesterone-mediated oocyte maturation, estrogen signaling pathway, and cellular senescence. Prognostic analyses indicated that the JUN, FASN, ADRB2, ADRA2A, and PGR were the hub genes, while molecular docking predicted the stable binding of ADRB2 protein with drug compounds. Additionally, [10]-Gingerol could induce apoptosis by regulating the caspase activation.Conclusions: [10]-Gingerol affects the growth of TNBC through multiple action targets and participating in multiple action pathways. ADRB2 and apoptosis pathways might be important target pathways for[10]-Gingerol in the treatment of TNBC.

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Progesterone Receptor (PGR) Gene Variants Associated with Breast Cancer and Associated Features: a Case-Control Study

Cited by 20 publications

References 30 publications

Genetic Factors of Idiopathic Gigantomastia: Clinical Implications of Aromatase and Progesterone Receptor Polymorphisms

Genetic Factors of Idiopathic Gigantomastia: Clinical Implications of Aromatase and Progesterone Receptor Polymorphisms

A Birth Cohort Study about the Genetic Modification of Prenatal Methylmercury Association with Child Cognitive Development

Exploring the molecular targets and mechanisms of [10]-Gingerol for treating triple-negative breast cancer using bioinformatics approaches, molecular docking, and in vivo experiments

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