Progesterone use in assisted reproductive technology

Labarta, Elena; Rodríguez, Cristina

doi:10.1016/j.bpobgyn.2020.05.005

Cited by 32 publications

(22 citation statements)

References 46 publications

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“…FSH and hCG) 400–800 mg daily, and in artificial cycles (women without spontaneous ovarian function, estrogen and progestogen treatment) 600–1000 mg daily [ 167 , 168 ]. Other doses and progesterone forms are reviewed in Labarata et al [ 169 ]. That group also suggests measuring serum PROG levels after embryo transfer.…”

Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine

Kolátorová

Vítků

Suchopár³

et al. 2022

IJMS

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Progesterone is a steroid hormone traditionally linked with female fertility and pregnancy. In current reproductive medicine, progesterone and its analogues play crucial roles. While the discovery of its effects has a long history, over recent decades, various novel actions of this interesting steroid have been documented, of which its neuro- and immunoprotective activities are the most widely discussed. Discoveries of the novel biological activities of progesterone have also driven research and development in the field of progesterone analogues used in human medicine. Progestogen treatment has traditionally and predominately been used in maintaining pregnancy, the prevention of preterm labor, various gynecological pathologies, and in lowering the negative effects of menopause. However, there are also various other medical fields where progesterone and its analogues could find application in the future. The aim of this work is to show the mechanisms of action of progesterone and its metabolites, the physiological and pharmacological actions of progesterone and its synthetic analogues in human medicine, as well as the impacts of its production and use on the environment.

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Section: Physiological and Pharmacological Actions Of Progesterone An...mentioning

confidence: 99%

Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine

Kolátorová

Vítků

Suchopár³

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…It should be highlighted that, although the clinical manifestations of a poor luteal activity are similar for women and cows, the intensive protocols used in assisted human reproduction may have had a negative influence on subsequent CL function. This makes P4-based therapies particularly indispensable in women [ 63 , 64 ].…”

Section: The Situation In Other Mammalian Speciesmentioning

confidence: 99%

Clinical Overview of Luteal Deficiency in Dairy Cattle

López‐Gatius¹,

García-Ispierto

2022

Animals

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Luteal deficiency is defined as reduced progesterone (P4) steroidogenesis by the corpus luteum (CL), either in the amount or duration, or both. This work provides a clinical overview of the current understanding of luteal deficiency and its association with low fertility in dairy cows. Low plasma P4 concentrations during the luteal phase post-artificial insemination (AI) are associated with lower conception rates. Treatments post-AI with P4, gonadotropin-releasing hormone (GnRH) or human chorionic gonadotropin (hCG) improve fertility in some conditions. Sub-luteal function during the late embryonic period (at pregnancy diagnosis, i.e., 28–34 days post-AI), is just one factor among other factors associated with pregnancy loss. Treatment with P4 in cows with one CL favors pregnancy maintenance, while GnRH treatment does the same in cows carrying twins. The diagnosis of sub-luteal function can be made clinically on the basis of plasma or milk P4 concentrations. Automated in-line milk P4 analysis systems to diagnose luteal activity emerge as a very interesting tool in dairy herds. Monitoring plasma or milk P4 concentrations with the help of Doppler ultrasonography to assess the CL function would allow individualizing the luteal phase support.

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“…Following ovulation, the remaining FG cells and theca cells differentiate into the CL, a temporary endocrine structure whose principal role is to secrete the hormone progesterone (P4). P4 is essential for pregnancy maintenance by sustaining the uterine mucosa (Arck et al, 2007) and is often administered to individuals with luteal insufficiencies or undergoing assisted reproduction to prevent miscarriage (Labarta, 2020;Labarta and Rodrı ´guez, 2020).…”

Section: Introductionmentioning

confidence: 99%