The documented annual risk of ischemic cardiac, cerebral and other vascular events in patients with carotid stenosis depends upon the population studied, in addition to other established risk factors. The control groups included in medical or surgical trials are selected populations and are usually found to have lower event rates than the total cohort. Community studies indicate that, in patients with asymptomatic carotid disease, the annual stroke rate is about 1–2%, and that the death rate (usually due to cardiac causes) is 4–5%. Among the many factors influencing outcome, the severity of carotid stenosis is probably the most dominant. Patients with carotid stenoses of < 75% have annual stroke rates of 1–2%, while those with carotid stenoses of > 75 % have annual stroke rates of 5–6%, with a proportionately increased death rate. When symptomatic and asymptomatic groups are compared and matched for age and sex, a higher prevalence of carotid stenosis is found in stroke patients than in transient ischemic attack (TIA) patients; both stroke and TIA patients have more frequent and more severe carotid stenosis than asymptomatic patients. In patients with TIA and stroke, the evaluation of vascular risks also depends on the conditions under which the population has been studied. Community studies, especially those with prospective follow-up, such as the Mayo Clinic series, allow a more generalized perspective. In patients with TIA, the annual incidence of stroke is approximately 5–7%, and the annual death rate is approximately 7%. In patients with completed ischemic stroke, the annual rate of recurrent stroke is 10%, and the annual death rate is approximately 7%. The vascular outcome depends on a variety of factors. Morbidity and mortality are lower after vertebrobasilar strokes than after carotid strokes; outcome is also affected by clinical factors, such as age, and the presence of concomitant stroke risk factors, such as hypertension. In all forms of cerebrovascular disease, both symptomatic and asymptomatic the incidence of myocardial infarction and cardiac death is 4–5 times higher than the-incidence of stroke.