Prognosis and disease progression in patients under 50 years old undergoing PCI: The CRAGS (Coronary aRtery diseAse in younG adultS) study

Temporal trends and outcomes of percutaneous coronary intervention in young patients (aged ≤40 years)

“…In a population of young adults diagnosed with MI, the percentage of smokers can reach up to 74%, like in the CRAGS (Coronary Artery Disease in Young Adults) study. 23 With regard to angiographic characteristics, the lower atherosclerotic burden among young adults explains the higher prevalence of single-vessel coronary artery disease, as seen in the present study, which is consistent with previous publications. 16 As a result, there was a smaller number of treated vessels and stents utilized per patient in younger patients, as well as greater involvement of the left anterior descending artery.…”

“…22 In addition, young patients who do not control their risk factors have recurring disease over time, including the need for new CABG. 23 Young patients with ischemic heart disease have a higher probability of being smokers and having positive family history, but a lower rate of diabetes. [24][25][26] The present study reports the prevalence of smoking at roughly 35 to 40%, with progressive reduction over the 10 year-period (2006-2016).…”

Predictors of permanent work disability among ≤50-year-old patients undergoing percutaneous coronary intervention

“…On the other hand, most of the post-PCI revascular- Gunn et al ization procedures in this registry were performed due to disease progression suggesting that shortcomings in secondary prevention play a larger role (3). Based on the results, <50-year-old patients have an almost universal optimal medication at the time of hospital discharge from PCI.…”

“…Even though the percentage of actual psychiatric diagnoses in the present study was in fact lower than in the PWD cases of the general population a psychosocial burden is likely in young patients undergoing PCI. Alluding to this for example is the high prevalence of smoking of about 70% which is distinctly higher than in the general Finnish population (Finnish National Institute for Health and Healthcare 2013 Tobacco Statistics) and the high prevalence of smoking is typical for lower socioeconomic demographics (3,27). Cardiac rehabilitation, in addition to improving functional status cost-effectively (28,29), has a protective effect against cardiac events further preserving function and working ability (30,31).…”

“…In this pre-specified analysis of the CRAGS (Coronary aRtery diseAse in younG adultS) registry we sought to assess the role of periprocedural factors related to PCI in the incidence, indications, and determinants of permanent disability pension in long-term follow-up of ≤50-year-old patients who have undergone PCI (1)(2)(3).…”