The aim is to present the results of the anamnesis, diagnosis and treatment of a case of a combination of malignant melanoma of the skin and basal cell carcinoma of the skin in a patient with HIV infection. Material and methods. The clinical observation of the development of multiple skin lesions with malignant neoplasms (melanoma and basal cell carcinoma) against the background of HIV infection in a patient with low adherence to follow-up and antiretroviral therapy (ART) is described. Clinical and anamnestic data, results of examination and therapy are presented. Results and discussion. Malignant neoplasms of the patient’s skin were first identified by a dermatovenerologist. The patient was routed to an oncologist, fully examined and successfully treated with a combined method (surgical removal of tumors, photodynamic therapy and immunotherapy). Further observation and examination revealed the metastasis of melanoma. The above observation indicates the need for timely and comprehensive examination of people living with HIV (PLHIV) for early detection of oncological diseases. The case demonstrates the possibility of obtaining effective treatment of a malignant neoplasm of the skin against the background of immunosuppression in the short term, despite the patient’s low adherence to therapy. Conclusion. It is especially important for outpatient doctors (infectious disease specialists, dermatovenerologists, surgeons, etc.) to be oncological when working with PLHIV. It is necessary to include malignant neoplasms of the skin, including melanoma and basal cell carcinoma, in the range of differential diagnostic search for erosive ulcerative and nodular lesions. The presented case highlights the need for timely provision of comprehensive medical care and proper routing of comorbid patients.
