Prognosis in Arteriosclerotic Peripheral Vascular Disease

Silbert, Samuel; Zazeela, Herman

doi:10.1001/jama.1958.02990150012002

Cited by 59 publications

(14 citation statements)

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“…Several studies have shown that mortality rates may be increased fivefold in diabetics with arterial disease relative to those free of disease 40 – 42 . Jelnes, 31 however, found that diabetes was not independently related to death in his cohort of male and female patients with intermittent claudication, and our results are in general agreement with his finding.…”

Section: Discussionsupporting

confidence: 91%

The Relationship between Ankle‐Arm Index and Mortality in Older Men and Women

Vogt¹,

McKenna²,

Anderson³

et al. 1993

J American Geriatrics Society

121

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Section: Discussionsupporting

confidence: 91%

The Relationship between Ankle‐Arm Index and Mortality in Older Men and Women

Vogt¹,

McKenna²,

Anderson³

et al. 1993

J American Geriatrics Society

121

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“…The most important risk factors for all‐cause mortality are low ABPI, male gender, age, concomitant CHD, hypertension, diabetes and smoking [2]. Diabetes and smoking are two aggressive risk factors for major amputation [18–20].…”

Section: Introductionmentioning

confidence: 99%

Classification, epidemiology, risk factors, and natural history of peripheral arterial disease

Novo

2002

Diabetes Obesity Metabolism

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Peripheral arterial disease (PAD) is a clinical condition that has often been neglected. The clinical diagnosis of PAD may be made on the basis of an accurate history by using the WHO/Rose Questionnaire or the Edinburgh Questionnaire. From a clinical point of view, PAD may be classified into four stages. The PARTNERS Programme (PAD Awareness, Risk and Treatment: NEw Resources for Survival) is a recent study based on a partnership to improve PAD care. In this population, the prevalence of patients who were PAD+/CVD- was approximately 12% in males and 15% in females; PAD+/CVD+ approximately 18% in males and 14% in females; PAD-/CVD+ 28% in males and 17% in females; and finally, patients without vascular disease (PAD-/CVD-) 42% in males and 54% in females. The lessons derived from the PARTNERS Programme Study were informative; PAD is detectable in routine practice, using a simple, inexpensive, always available, clinical test such as calculation of the ankle-brachial pressure index (ABPI). Fewer than half of individuals with PAD are aware of their condition, while physicians are unaware of the presence of PAD in 70% of their patients with the condition. Diabetics and smokers are at high risk for PAD. Diabetes is present in about 41% of patients with PAD and a history of smoking (> 10 pack for year) is present in over 63% of patients with PAD. Antiplatelet therapy is taken by only about half of patients with PAD. Finally, the lack of diagnosis and treatment means that PAD patients remain at elevated risk of heart attack and stroke. Efforts must be made to diffuse this information to improve the diagnosis and treatment of PAD to reduce the risk of future fatal and nonfatal cardiac and cerebrovascular events.

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“…Much less is known about the epidemiology of arterial insufficiency in the lower extremities than about that of the two major cardiovascular diseases, coronary heart disease and atherosclerotic cerebrovascular disease. Most of the information on presentation, associated factors and prognosis of atherosclerosis obliterans of the lower extremities is based on clinical studies (1, 3, 14, 15, 16,19,39).…”

mentioning

confidence: 99%

Prevalence of Intermittent Claudication and Its Effect on Mortality

Reunanen

Takkunen

Aromaa

1982

Journal of Internal Medicine

268

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The prevalence of symptoms of intermittent claudication and their association with 5-year mortality were examined in a population study in Finland. A number of 5 738 men and 5 224 women, aged 30-59 years, from 4 geographic areas of the country were studied. According to a structured interview, 2.1% of the men and 1.8% of the women reported typical symptoms of intermittent claudication. Claudication was most prevalent in East Finland and among persons with agricultural occupations. The symptoms were more frequent in diabetics and persons with symptoms and signs of coronary heart disease (CHD) than in persons without these diseases. High serum cholesterol and smoking were associated with these symptoms but high blood pressure was not. The risk of death from cardiovascular causes was nearly 3-fold in men with claudication compared to men without claudication. Symptoms of chest pain and smoking increased significantly the mortality risk of male claudicants. The validity of symptoms was poorer in women than in men and they were also less reliable predictors of death in women. A small part of the effect of claudication on mortality was due to its association with conventional CHD risk factors. However, after adjusting for symptoms and signs of CHD, claudication had no independent effect on mortality in men.

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Prognosis in Arteriosclerotic Peripheral Vascular Disease

Cited by 59 publications

References 0 publications

The Relationship between Ankle‐Arm Index and Mortality in Older Men and Women

The Relationship between Ankle‐Arm Index and Mortality in Older Men and Women

Classification, epidemiology, risk factors, and natural history of peripheral arterial disease

Prevalence of Intermittent Claudication and Its Effect on Mortality

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