Prognosis in autism: A follow-up study

DeMyer, Marian K.; Barton, Sandra; DeMyer, William; Norton, James A.; Allen, John; Steele, Robert

doi:10.1007/bf01538281

Cited by 258 publications

(101 citation statements)

References 15 publications

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“…DeMyer et al [18] in a follow-up study found, as had others, that IQ scores were a good indicator of prognosis. Myklebust et al [19] state autistic children who used social perception, even if they had poor language, had a better outcome.…”

Section: Intelligencementioning

confidence: 88%

A psychopathogenesis of autism

Ney

1979

Child Psych Hum Dev

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ABSTRACT" It is possible that autistic children are not neurophysiologieally abnormal but children with hearing hyperacuity, born into an environment that cannot adapt to them. If so, to them, human sounds are not soothing but frightening. Environmental noises do not arouse curiosity but hurt so much the child withdraws. Because of self-imposed isolation, the child's brain hungers for stimulation, increasing the level of arousal which results in an anxietyevoking experience of sound in addition to pain. Parents mistake the withdrawal as a signal tbr them to tl3' to communicate more vigorously thereby increasing the child's fear of them. Parents eventually lem'n to remain cool and aloof but this deprives the child of alternate forms of stimulation. The net result is an information-det)rived brain, an inability to interpret auditory symbols and, eventually, irreversible retardation.In the search for the etiology of childhood primary autism, some consideration should be given to the possibility that there is essentially nothing abnormal. Is it not possible that autistic children do not have a neurophysiological deficit but a hypersensitivity that makes it impossible for them to adapt to this sensorially jarring world?Since intelligence has a Gaussian distribution, it is highly probable that the neurological components of intelligence have the same distribution. A very small percentage of children will have sensory acuities well beyond the mean. Those children with sensitive hearing would find their environment so cacophonous that the only adaptive response would be to withdraw and not engage in any behavior such as communicating that would evoke more auditory discomfort.

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Section: Intelligencementioning

confidence: 88%

A psychopathogenesis of autism

Ney

1979

Child Psych Hum Dev

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“…29 ) Given two children with similar levels of atypicality, the functional outcome is better for the child with the higher IQ. 16,20,27,[30][31][32][33][34][35][36] What is not clear is whether the more favorable outcome for this group is simply due to higher IQ in itself (as would be true for children without ASD) or whether it is also tied to a greater decrease in expression of autistic symptoms over time among children without mental retardation. As additional data are collected with more refined tools such as the ADOS 5 or the Diagnostic Interview for Social and Communication Disorders, 6 it will be useful to map these data onto this three-dimensional space, to gain a fuller understanding of the interactions among these three variables: atypicality, intelligence, and age.…”

Section: Discussionmentioning

confidence: 99%

Atypicality, intelligence, and age: a conceptual model of autistic spectrum disorder

Coplan¹

2003

Develop Med Child Neuro

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“…In order to obtain a fairly homogeneous group, the DeMyer-Churchill guidelines (DeMyer et al, 1971) were used. The children to be tested were to meet the DeMyer-Churcltill guidelines for either early schizo phrenia or primary autism, since renamed high and middle autism (DeMyer et al, 1973). See table J.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Plasma from Psychotic Children on Tryptophan Uptake in Chicken Erythrocytes

Piggott¹,

Frohman²,

Ward³

et al. 1975

Neuropsychobiology

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Ten children diagnosed as psychotic by the DeMyer-Churchill guidelines were matched for age and sex with ten non-psychotic but emotionally disturbed children. Six of the ten pairs were medication free. In four of the ten pairs, at least one member was medicated at the time of testing. The plasma of the children diagnosed as psychotic caused a significantly (p < 0.025) greater uptake of tryptophan by chicken red blood cells than did the serum of their control group. This is the same effect on tryptophan uptake as found when the plasma of adult patients with process schizophrenia is incubated with chicken erythrocytes and tryptophan. This finding lends support to the possibility that there is a subgroup of childhood psychotic patients who have a biological disturbance similar to that found in adult process schizophrenic patients.

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Prognosis in autism: A follow-up study

Cited by 258 publications

References 15 publications

A psychopathogenesis of autism

A psychopathogenesis of autism

Atypicality, intelligence, and age: a conceptual model of autistic spectrum disorder

The Effect of Plasma from Psychotic Children on Tryptophan Uptake in Chicken Erythrocytes

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